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Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic Chagas disease: Correlation between antibody titers and development of cardiac disease severity.

Abstract Chagas disease is one of the most important endemic infections in Latin America affecting around 6-7 million people. About 30-50% of patients develop the cardiac form of the disease, which can lead to severe cardiac dysfunction and death. In this scenario, the identification of immunological markers of disease progression would be a valuable tool for early treatment and reduction of death rates. In this observational study, the production of anti-Trypanosoma cruzi antibodies through a retrospective longitudinal follow-up in chronic Chagas disease patients´ cohort and its correlation with disease progression and heart commitment was evaluated. Strong inverse correlation (ρ = -0.6375, p = 0.0005) between anti-T. cruzi IgG1 titers and left ventricular ejection fraction (LVEF) in chronic Chagas cardiomyopathy (CCC) patients were observed after disease progression. Elevated levels of anti-T. cruzi IgG3 titers were detected in all T. cruzi-infected patients, indicating a lack of correlation of this IgG isotype with disease progression. Furthermore, low levels of anti-T. cruzi IgG2, IgG4, and IgA were detected in all patients through the follow-up. Although without statistical significance anti-T. cruzi IgE tends to be more reactive in patients with the indeterminate form (IND) of the disease (p = 0.0637). As this study was conducted in patients with many years of chronic disease no anti-T. cruzi IgM was detected. Taken together, these results indicate that the levels of anti-T. cruzi IgG1 could be considered to seek for promising biomarkers to predict the severity of chronic Chagas disease cardiomyopathy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28723905
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170809
LR  - 20170809
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul
TI  - Evolution of anti-Trypanosoma cruzi antibody production in patients with chronic 
      Chagas disease: Correlation between antibody titers and development of cardiac
      disease severity.
PG  - e0005796
LID - 10.1371/journal.pntd.0005796 [doi]
AB  - Chagas disease is one of the most important endemic infections in Latin America
      affecting around 6-7 million people. About 30-50% of patients develop the cardiac
      form of the disease, which can lead to severe cardiac dysfunction and death. In
      this scenario, the identification of immunological markers of disease progression
      would be a valuable tool for early treatment and reduction of death rates. In
      this observational study, the production of anti-Trypanosoma cruzi antibodies
      through a retrospective longitudinal follow-up in chronic Chagas disease patients
      cohort and its correlation with disease progression and heart commitment was
      evaluated. Strong inverse correlation (rho = -0.6375, p = 0.0005) between anti-T.
      cruzi IgG1 titers and left ventricular ejection fraction (LVEF) in chronic Chagas
      cardiomyopathy (CCC) patients were observed after disease progression. Elevated
      levels of anti-T. cruzi IgG3 titers were detected in all T. cruzi-infected
      patients, indicating a lack of correlation of this IgG isotype with disease
      progression. Furthermore, low levels of anti-T. cruzi IgG2, IgG4, and IgA were
      detected in all patients through the follow-up. Although without statistical
      significance anti-T. cruzi IgE tends to be more reactive in patients with the
      indeterminate form (IND) of the disease (p = 0.0637). As this study was conducted
      in patients with many years of chronic disease no anti-T. cruzi IgM was detected.
      Taken together, these results indicate that the levels of anti-T. cruzi IgG1
      could be considered to seek for promising biomarkers to predict the severity of
      chronic Chagas disease cardiomyopathy.
FAU - Georg, Ingebourg
AU  - Georg I
AD  - Setor de Imunodiagnostico, Instituto Nacional de Infectologia Evandro Chagas,
      Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Hasslocher-Moreno, Alejandro Marcel
AU  - Hasslocher-Moreno AM
AD  - Laboratorio de Pesquisa Clinica em Doenca de Chagas, Instituto Nacional de
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de
      Janeiro, Brazil.
FAU - Xavier, Sergio Salles
AU  - Xavier SS
AD  - Laboratorio de Pesquisa Clinica em Doenca de Chagas, Instituto Nacional de
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de
      Janeiro, Brazil.
FAU - Holanda, Marcelo Teixeira de
AU  - Holanda MT
AD  - Laboratorio de Pesquisa Clinica em Doenca de Chagas, Instituto Nacional de
      Infectologia Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de
      Janeiro, Brazil.
FAU - Roma, Eric Henrique
AU  - Roma EH
AUID- ORCID: http://orcid.org/0000-0001-5265-5277
AD  - Laboratorio de Imunologia e Imunogenetica em Doencas Infecciosas. Instituto
      Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Bonecini-Almeida, Maria da Gloria
AU  - Bonecini-Almeida MDG
AD  - Laboratorio de Imunologia e Imunogenetica em Doencas Infecciosas. Instituto
      Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Rio de Janeiro, Brazil.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170719
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies, Protozoan/*blood
MH  - Biomarkers/blood
MH  - Chagas Cardiomyopathy/*pathology
MH  - Chronic Disease
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Trypanosoma cruzi/*immunology
MH  - Young Adult
PMC - PMC5536389
EDAT- 2017/07/21 06:00
MHDA- 2017/08/10 06:00
CRDT- 2017/07/21 06:00
PHST- 2017/01/19 [received]
PHST- 2017/07/11 [accepted]
PHST- 2017/07/31 [revised]
AID - 10.1371/journal.pntd.0005796 [doi]
AID - PNTD-D-17-00096 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Jul 19;11(7):e0005796. doi:
      10.1371/journal.pntd.0005796. eCollection 2017 Jul.