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Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in Multiple Sclerosis.

Abstract To evaluate whether corneal confocal microscopy (CCM) detects axonal degeneration and whether this is associated with retinal nerve fiber degeneration and clinical disability in patients with multiple sclerosis (MS).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28727882
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Corneal Confocal Microscopy: An Imaging Endpoint for Axonal Degeneration in
      Multiple Sclerosis.
PG  - 3677-3681
LID - 10.1167/iovs.17-22050 [doi]
AB  - Purpose: To evaluate whether corneal confocal microscopy (CCM) detects axonal
      degeneration and whether this is associated with retinal nerve fiber degeneration
      and clinical disability in patients with multiple sclerosis (MS). Methods:
      Twenty-five patients with MS and 25 healthy control subjects underwent CCM,
      optical coherence tomography (OCT), and assessment of neurological disability
      using the expanded disability status scale (EDSS) and MS severity score (MSSS).
      Results: In patients with MS compared with controls, there was a significant
      reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and
      length (CNFL). There was no significant difference in CCM parameters between
      patients with optic neuritis (MS-ON) and without (MS-NON), or between
      relapsing-remitting (RRMS) and secondary-progressive MS (SPMS). There was
      significant thinning of the retinal nerve fiber layer (RNFL) in the global,
      temporal, temporal superior, and temporal inferior quadrants, with no difference 
      between MS-ON and MS-NON. Patients with SPMS compared with RRMS had a
      significantly lower global, temporal superior, temporal inferior, nasal, and
      nasal superior RNFL. The EDSS and MSSS correlated significantly with CNBD, nasal,
      nasal superior, and nasal inferior RNFL and with CNBD and nasal inferior RNFL,
      respectively. Conclusions: CCM and OCT detect significant corneal and retinal
      nerve degeneration which relates to the severity of neurological deficits in
      patients with mild MS.
FAU - Petropoulos, Ioannis N
AU  - Petropoulos IN
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
FAU - Kamran, Saadat
AU  - Kamran S
AD  - Institute of Neurosciences, Hamad General Hospital, Doha, Qatar.
FAU - Li, Yi
AU  - Li Y
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
FAU - Khan, Adnan
AU  - Khan A
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
FAU - Ponirakis, Georgios
AU  - Ponirakis G
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
FAU - Akhtar, Naveed
AU  - Akhtar N
AD  - Institute of Neurosciences, Hamad General Hospital, Doha, Qatar.
FAU - Deleu, Dirk
AU  - Deleu D
AD  - Institute of Neurosciences, Hamad General Hospital, Doha, Qatar.
FAU - Shuaib, Ashfaq
AU  - Shuaib A
AD  - Institute of Neurosciences, Hamad General Hospital, Doha, Qatar.
FAU - Malik, Rayaz A
AU  - Malik RA
AD  - Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Axons/*pathology
MH  - Cornea/*innervation
MH  - Female
MH  - Humans
MH  - Male
MH  - Microscopy, Confocal
MH  - Multiple Sclerosis/*diagnostic imaging/pathology
MH  - Nerve Degeneration/*diagnostic imaging/pathology
MH  - Optic Neuritis/*diagnostic imaging/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Trigeminal Nerve/*pathology
MH  - Trigeminal Nerve Diseases/*diagnostic imaging/pathology
EDAT- 2017/07/21 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/21 06:00
AID - 2645785 [pii]
AID - 10.1167/iovs.17-22050 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3677-3681. doi:
      10.1167/iovs.17-22050.