PubTransformer

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PMID- 28727884
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - OCT Angiography and Ellipsoid Zone Mapping of Macular Telangiectasia Type 2 From 
      the AVATAR Study.
PG  - 3683-3689
LID - 10.1167/iovs.16-20976 [doi]
AB  - Purpose: To evaluate alterations on optical coherence tomography angiography
      (OCT-A) and quantitatively assess alterations in the ellipsoid zone (EZ) in eyes 
      with macular telangiectasia type 2 (MacTel type 2). Methods: The Observational
      Assessment of Visualizing and Analyzing Vessels With Optical Coherence Tomography
      Angiography in Retinal Diseases study is an institutional review board-approved
      prospective, observational study investigating OCT-A in macular disease. Patients
      underwent spectral-domain (SD)-OCT and OCT-A imaging at a single visit. SD-OCT
      data were analyzed using a novel OCT EZ-mapping software to obtain linear, area, 
      and volumetric measurements of the EZ-retinal pigment epithelium (RPE) complex
      across the macular cube. OCT-A retinal capillary density was measured using the
      Optovue Avanti split-spectrum amplitude-decorrelation angiography algorithm.
      EZ-RPE parameters were compared to age-matched, sex-matched controls. Results:
      Fourteen eyes of seven patients (mean age, 59 +/- 6.5 years) were analyzed. Mean 
      visual acuity was 20/45 (range, 20/20-20/150). EZ-RPE central foveal mean
      thickness was 27.8 +/- 6.7 mum, EZ-RPE central foveal thickness was 22.1 +/- 21.6
      mum, EZ-RPE central foveal area was 0.17 +/- 0.04 mm2, and EZ-RPE central
      subfield volume was 0.017 +/- 0.012 mm3. Each of these measurements was
      significantly inversely correlated with visual acuity (P < 0.02). In addition,
      all of these measurements were significantly reduced compared to controls (all P 
      </= 0.005). OCT-A showed a reduced parafoveal vessel density of 50.8% temporally 
      compared to 53.8% nasally (P = 0.01) in the superficial vascular plexus. In the
      deep vascular plexus, similar findings were noted with a parafoveal vessel
      density of 56.7% temporally and 58.8% nasally (P = 0.01). Conclusions:
      Abnormalities in EZ-RPE thickness, area, and volume are correlated with visual
      acuity in MacTel type 2, and may provide quantitative markers to measure disease 
      progression and treatment response. OCT-A was a useful adjunct for determining
      disease severity.
FAU - Runkle, Anne P
AU  - Runkle AP
AD  - Ophthalmic Imaging Center, Cleveland Clinic, Cleveland, Ohio, United States 2Cole
      Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
FAU - Kaiser, Peter K
AU  - Kaiser PK
AD  - Ophthalmic Imaging Center, Cleveland Clinic, Cleveland, Ohio, United States 2Cole
      Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
FAU - Srivastava, Sunil K
AU  - Srivastava SK
AD  - Ophthalmic Imaging Center, Cleveland Clinic, Cleveland, Ohio, United States 2Cole
      Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
FAU - Schachat, Andrew P
AU  - Schachat AP
AD  - Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
FAU - Reese, Jamie L
AU  - Reese JL
AD  - Ophthalmic Imaging Center, Cleveland Clinic, Cleveland, Ohio, United States 2Cole
      Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
FAU - Ehlers, Justis P
AU  - Ehlers JP
AD  - Ophthalmic Imaging Center, Cleveland Clinic, Cleveland, Ohio, United States 2Cole
      Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States.
LA  - eng
GR  - K23 EY022947/EY/NEI NIH HHS/United States
GR  - T32 EY024236/EY/NEI NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Capillaries/pathology
MH  - Computed Tomography Angiography/methods
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retinal Photoreceptor Cell Inner Segment/*pathology
MH  - Retinal Photoreceptor Cell Outer Segment/*pathology
MH  - Retinal Pigment Epithelium/*pathology
MH  - Retinal Telangiectasis/*diagnosis/physiopathology
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
PMC - PMC5518977
EDAT- 2017/07/21 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/21 06:00
AID - 2645787 [pii]
AID - 10.1167/iovs.16-20976 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3683-3689. doi:
      10.1167/iovs.16-20976.