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Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes.

Abstract To quantitatively evaluate the superficial microvasculature in the macular and peripapillary areas in glaucomatous and healthy eyes using optical coherence tomography angiography (OCT-A).
PMID
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Authors

Mayor MeshTerms

Computed Tomography Angiography

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28728171
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Optical Coherence Tomography Angiography of the Superficial Microvasculature in
      the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes.
PG  - 3637-3645
LID - 10.1167/iovs.17-21846 [doi]
AB  - Purpose: To quantitatively evaluate the superficial microvasculature in the
      macular and peripapillary areas in glaucomatous and healthy eyes using optical
      coherence tomography angiography (OCT-A). Methods: We enrolled 26 eyes of
      medically managed primary open-angle glaucoma patients and 27 eyes of healthy
      subjects were enrolled in this prospective study. Measurements of OCT-A vessel
      density were acquired both in the macular and peripapillary areas. We compared
      vessel density values, the circumpapillary retinal nerve fiber layer (cpRNFL),
      the ganglion cell complex (GCC), and standard automated perimetry (SAP)
      parameters across study groups. Areas under the receiver operating characteristic
      (AUROC) curves were used to evaluate diagnostic accuracy. Quadratic regression
      models were used to determine the correlations between SAP severity and outcome
      measures. Results: The whole image vessel density (wiVD) in glaucomatous eyes was
      lower than that in healthy eyes in the macular (38.5% +/- 2.2% vs. 43.2% +/-
      2.3%, P < 0.001) and peripapillary areas (43.8% +/- 5.7% vs. 53.3% +/- 3.0%, P < 
      0.001). The circumpapillary vessel density (cpVD) was also lower in glaucomatous 
      eyes (53.3% +/- 7.0% vs. 61.5% +/- 3.2%, P < 0.001). We found the AUROCs for
      discriminating between glaucomatous and healthy eyes were highest for cpRNFL
      (0.95) and GCC (0.95); followed by macular wiVD (0.94); peripapillary wiVD
      (0.93); and cpVD (0.89). The correlations between SAP severity were strongest
      with peripapillary wiVD (R2 = 0.58); followed by cpVD (R2 = 0.55); GCC (R2 =
      0.51); cpRNFL (R2 = 0.42); and macular wiVD (R2 = 0.36). Conclusions: Medically
      managed glaucomatous eyes show sparser superficial microvasculature in the
      macular area than do healthy eyes. The measurement of the macular superficial
      vessel density had similar diagnostic accuracy to peripapillary RNFL and macular 
      GCC thickness for differentiating between glaucomatous and healthy eyes.
FAU - Chen, Henry Shen-Lih
AU  - Chen HS
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
      2College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Liu, Chun-Hsiu
AU  - Liu CH
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
FAU - Wu, Wei-Chi
AU  - Wu WC
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan
      2College of Medicine, Chang Gung University, Taoyuan, Taiwan.
FAU - Tseng, Hsiao-Jung
AU  - Tseng HJ
AD  - Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital,
      Linkou, Taiwan.
FAU - Lee, Yung-Sung
AU  - Lee YS
AD  - Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - Glaucoma, Primary Open Angle
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Computed Tomography Angiography/methods
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis/physiopathology
MH  - Healthy Volunteers
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Macula Lutea/*blood supply
MH  - Male
MH  - Microvessels/pathology
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*blood supply
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Vessels/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Field Tests
MH  - Visual Fields
EDAT- 2017/07/21 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/21 06:00
AID - 2645722 [pii]
AID - 10.1167/iovs.17-21846 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3637-3645. doi:
      10.1167/iovs.17-21846.