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Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced Retinal Degeneration by Inducing Bcl-xL in Rats.

Abstract The aim of the present study was to investigate the neuroprotective effects of glucocorticoid-induced leucine zipper (GILZ) in a light-induced retinal degeneration model and to explore the underlying mechanisms.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28728173
OWN - NLM
STAT- MEDLINE
DA  - 20170720
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Glucocorticoid-Induced Leucine Zipper Protects the Retina From Light-Induced
      Retinal Degeneration by Inducing Bcl-xL in Rats.
PG  - 3656-3668
LID - 10.1167/iovs.17-22116 [doi]
AB  - Purpose: The aim of the present study was to investigate the neuroprotective
      effects of glucocorticoid-induced leucine zipper (GILZ) in a light-induced
      retinal degeneration model and to explore the underlying mechanisms. Methods:
      Intravitreal injection of recombinant GILZ-overexpressing lentivirus
      (OE-GILZ-rLV) and short hairpin RNA targeting GILZ recombinant lentivirus
      (shRNA-GILZ-rLV) was performed to up- and downregulate retinal GILZ,
      respectively. Three days after stable transduction, rats were exposed to
      continuous bright light (5000 lux) for 2 days. Retinal function was assessed by
      full-field electroretinography (ERG), and the retinal structure was examined for 
      photoreceptor survival and death in rats kept under a 12-hour light:2-hour dark
      cycle following light exposure. The expression levels of retinal Bcl-xL,
      caspase-9, and caspase-3 were examined by Western blotting or real-time PCR at 1,
      3, 5, and 7 days after light exposure. Results: Exposure to bright light
      downregulated retinal GILZ in parallel with the downregulation of Bcl-xL and the 
      upregulation of active caspase-3. Overexpression of retinal GILZ attenuated the
      decrease of Bcl-xL and the activation of caspase-9 and caspase-3 at 1, 3, 5, and 
      7 days after bright light exposure, respectively. GILZ silencing aggravated the
      downregulation of Bcl-xL induced by bright light exposure. Bright light exposure 
      reduced the amplitude of ERG, increased the number of apoptotic photoreceptor
      cells, and decreased retinal thickness; and GILZ overexpression could attenuate
      all these effects. Conclusions: Overexpression of GILZ by OE-GILZ-rLV
      transduction protected the retina from light-induced cellular damage by
      activating antiapoptotic pathways.
FAU - Gu, Ruiping
AU  - Gu R
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China.
FAU - Tang, Wenyi
AU  - Tang W
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China.
FAU - Lei, Boya
AU  - Lei B
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China.
FAU - Ding, Xinyi
AU  - Ding X
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China.
FAU - Jiang, Cheng
AU  - Jiang C
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China.
FAU - Xu, Gezhi
AU  - Xu G
AD  - Department of Ophthalmology, Eye and Ear Nose Throat Hospital of Fudan
      University, Shanghai, China 2Shanghai Key Laboratory of Visual Impairment and
      Restoration, Fudan University, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Bcl2l1 protein, rat)
RN  - 0 (Gilz protein, rat)
RN  - 0 (Transcription Factors)
RN  - 0 (bcl-X Protein)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Blotting, Western
MH  - Electroretinography
MH  - Gene Expression Regulation/*physiology
MH  - Gene Silencing/physiology
MH  - In Situ Nick-End Labeling
MH  - Intravitreal Injections
MH  - Lentivirus/genetics
MH  - Light/adverse effects
MH  - Male
MH  - Radiation Injuries, Experimental/genetics/physiopathology/*prevention & control
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Retina/physiopathology/*radiation effects
MH  - Retinal Degeneration/genetics/physiopathology/*prevention & control
MH  - Transcription Factors/*genetics
MH  - Transduction, Genetic
MH  - bcl-X Protein/*metabolism
EDAT- 2017/07/21 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/21 06:00
AID - 2645724 [pii]
AID - 10.1167/iovs.17-22116 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3656-3668. doi:
      10.1167/iovs.17-22116.