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Disease severity in patients with visceral leishmaniasis is not altered by co-infection with intestinal parasites.

Abstract Visceral leishmaniasis (VL) is a neglected tropical disease that affects the poorest communities and can cause substantial morbidity and mortality. Visceral leishmaniasis is characterized by the presence of Leishmania parasites in the spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever, systemic inflammation and low body mass index (BMI). The factors impacting on the severity of VL are poorly characterized. Here we performed a cross-sectional study to assess whether co-infection of VL patients with intestinal parasites influences disease severity, assessed with clinical and haematological data, inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL patients co-infected with intestinal parasites, suggesting that co-infection of VL patients with intestinal parasites does not alter disease severity.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28732017
OWN - NLM
STAT- In-Process
DA  - 20170721
LR  - 20170802
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 7
DP  - 2017 Jul
TI  - Disease severity in patients with visceral leishmaniasis is not altered by
      co-infection with intestinal parasites.
PG  - e0005727
LID - 10.1371/journal.pntd.0005727 [doi]
AB  - Visceral leishmaniasis (VL) is a neglected tropical disease that affects the
      poorest communities and can cause substantial morbidity and mortality. Visceral
      leishmaniasis is characterized by the presence of Leishmania parasites in the
      spleen, liver and bone marrow, hepatosplenomegaly, pancytopenia, prolonged fever,
      systemic inflammation and low body mass index (BMI). The factors impacting on the
      severity of VL are poorly characterized. Here we performed a cross-sectional
      study to assess whether co-infection of VL patients with intestinal parasites
      influences disease severity, assessed with clinical and haematological data,
      inflammation, cytokine profiles and BMI. Data from VL patients was similar to VL 
      patients co-infected with intestinal parasites, suggesting that co-infection of
      VL patients with intestinal parasites does not alter disease severity.
FAU - Tajebe, Fitsumbrhan
AU  - Tajebe F
AD  - Department of Immunology and Molecular Biology, University of Gondar, Gondar,
      Ethiopia.
FAU - Getahun, Mulusew
AU  - Getahun M
AD  - Department of Immunology and Molecular Biology, University of Gondar, Gondar,
      Ethiopia.
FAU - Adem, Emebet
AU  - Adem E
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
FAU - Hailu, Asrat
AU  - Hailu A
AD  - Department of Microbiology, Immunology and Parasitology, Addis Ababa University, 
      Addis Ababa, Ethiopia.
FAU - Lemma, Mulualem
AU  - Lemma M
AD  - Department of Internal Medicine, University of Gondar, Gondar, Ethiopia.
FAU - Fikre, Helina
AU  - Fikre H
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
FAU - Raynes, John
AU  - Raynes J
AD  - Department of Immunology and Infection, London School of Hygiene and Tropical
      Medicine, London, United Kingdom.
FAU - Tamiru, Aschalew
AU  - Tamiru A
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
FAU - Mulugeta, Zemenay
AU  - Mulugeta Z
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
FAU - Diro, Ermias
AU  - Diro E
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
AD  - Department of Internal Medicine, University of Gondar, Gondar, Ethiopia.
FAU - Toulza, Frederic
AU  - Toulza F
AD  - Department of Haematological Medicine, Faculty of Life Sciences, King's College, 
      London, United Kingdom.
FAU - Shkedy, Ziv
AU  - Shkedy Z
AD  - Department of Mathematics and Statistics, University of Hasselt, Hasselt,
      Belgium.
FAU - Ayele, Tadesse
AU  - Ayele T
AD  - Department of Mathematics and Statistics, University of Hasselt, Hasselt,
      Belgium.
FAU - Modolell, Manuel
AU  - Modolell M
AD  - Department of Cellular Immunology, Max-Planck-Institute for Immunobiology and
      Epigenetics, Freiburg, Germany.
FAU - Munder, Markus
AU  - Munder M
AD  - Third Department of Medicine (Hematology, Oncology, and Pneumology), University
      Medical Center Mainz, Mainz, Germany.
FAU - Muller, Ingrid
AU  - Muller I
AD  - Department of Medicine, Imperial College London, London, United Kingdom.
FAU - Takele, Yegnasew
AU  - Takele Y
AD  - Leishmaniasis Research and Treatment Centre, University of Gondar, Gondar,
      Ethiopia.
AD  - Department of Medicine, Imperial College London, London, United Kingdom.
FAU - Kropf, Pascale
AU  - Kropf P
AUID- ORCID: http://orcid.org/0000-0002-1670-8332
AD  - Department of Medicine, Imperial College London, London, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20170721
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/07/22 06:00
MHDA- 2017/07/22 06:00
CRDT- 2017/07/22 06:00
PHST- 2016/10/08 [received]
PHST- 2017/06/19 [accepted]
PHST- 2017/08/02 [revised]
AID - 10.1371/journal.pntd.0005727 [doi]
AID - PNTD-D-16-01833 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Jul 21;11(7):e0005727. doi:
      10.1371/journal.pntd.0005727. eCollection 2017 Jul.