PubTransformer

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PMID- 28738134
OWN - NLM
STAT- MEDLINE
DA  - 20170724
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Indocyanine Green Angiography and Optical Coherence Tomography Angiography of
      Choroidal Neovascularization in Age-Related Macular Degeneration.
PG  - 3690-3696
LID - 10.1167/iovs.17-21941 [doi]
AB  - Purpose: To compare the capability of indocyanine green angiography (ICGA) and
      optical coherence tomography angiography (OCTA) in detecting choroidal
      neovascularization (CNV). Methods: In this prospective study, patients with CNV
      detected with fluorescein angiography (FA) underwent ICGA and OCTA, spectral
      domain OCT (SD-OCT), and infrared or fundus color photographs. CNV lesions were
      outlined on ICGA and OCTA images, and the composition and size of the CNV was
      documented. Results: One hundred eighty-two eyes were included. With ICGA,
      well-defined lesions were observed in 37.9%, partly defined in 44.5%, and
      undefined in 17% of eyes. On OCTA, well-defined, partly defined, and undefined
      vessels were observed in 53.8%, 27.5%, and 18.7% of eyes, respectively. There was
      a good correlation between CNV size measured with the two instruments (r = 0.84).
      However, OCTA underestimated CNV area by about 4.5% (slope coefficient with
      linear regression: 0.55, 95% confidence interval [CI]: 0.46 to 0.65; intercept:
      0.27, 95% CI: -0.2 to 0.56). On ICGA, CNV composition was capillary in 28%,
      mature in 14.3%, and mixed (capillary and major neovascular complex) in 57.7% of 
      eyes. Similarly, OCTA revealed capillary, mature, and mixed CNV in 28.9%, 15.9%, 
      and 55.5% of eyes, respectively. Conclusions: OCTA provides the clinician the
      ability to perform precise structural and vascular assessment of CNV
      noninvasively. Our study is, to our knowledge, the largest OCTA analysis to date 
      of CNV secondary to neovascular AMD analyzed simultaneously by ICGA and OCTA.
FAU - Eandi, Chiara M
AU  - Eandi CM
AD  - Department of Surgical Sciences, Eye Clinic, University of Torino, Italy.
FAU - Ciardella, Antonio
AU  - Ciardella A
AD  - Azienda Ospedaliero-Universitaria di Bologna-Policlinico S. Orsola-Malpighi,
      Unita Operativa Oftalmologia-Ciardella, Bologna, Italy.
FAU - Parravano, Mariacristina
AU  - Parravano M
AD  - IRCCS Fondazione G.B. Bietti, Rome, Italy.
FAU - Missiroli, Filippo
AU  - Missiroli F
AD  - Department of Surgery and Experimental Medicine, University Tor Vergata, Rome,
      Italy.
FAU - Alovisi, Camilla
AU  - Alovisi C
AD  - Department of Surgical Sciences, Eye Clinic, University of Torino, Italy.
FAU - Veronese, Chiara
AU  - Veronese C
AD  - Azienda Ospedaliero-Universitaria di Bologna-Policlinico S. Orsola-Malpighi,
      Unita Operativa Oftalmologia-Ciardella, Bologna, Italy.
FAU - Morara, Maria C
AU  - Morara MC
AD  - Azienda Ospedaliero-Universitaria di Bologna-Policlinico S. Orsola-Malpighi,
      Unita Operativa Oftalmologia-Ciardella, Bologna, Italy.
FAU - Grossi, Massimo
AU  - Grossi M
AD  - Department of Surgery and Experimental Medicine, University Tor Vergata, Rome,
      Italy.
FAU - Virgili, Gianni
AU  - Virgili G
AD  - Department of Translational Surgery and Medicine, University of Florence,
      Florence, Italy.
FAU - Ricci, Federico
AU  - Ricci F
AD  - Department of Surgery and Experimental Medicine, University Tor Vergata, Rome,
      Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Coloring Agents)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroidal Neovascularization/*diagnosis/physiopathology
MH  - Coloring Agents/*administration & dosage
MH  - Computed Tomography Angiography
MH  - Female
MH  - *Fluorescein Angiography
MH  - Humans
MH  - Indocyanine Green/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Wet Macular Degeneration/*diagnosis/physiopathology
EDAT- 2017/07/25 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/25 06:00
AID - 2645838 [pii]
AID - 10.1167/iovs.17-21941 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3690-3696. doi:
      10.1167/iovs.17-21941.