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Reliability and Repeatability of Cone Density Measurements in Patients With Stargardt Disease and RPGR-Associated Retinopathy.

Abstract To assess reliability and repeatability of cone density measurements by using confocal and (nonconfocal) split-detector adaptive optics scanning light ophthalmoscopy (AOSLO) imaging. It will be determined whether cone density values are significantly different between modalities in Stargardt disease (STGD) and retinitis pigmentosa GTPase regulator (RPGR)-associated retinopathy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28738413
OWN - NLM
STAT- MEDLINE
DA  - 20170724
DCOM- 20170728
LR  - 20170728
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Reliability and Repeatability of Cone Density Measurements in Patients With
      Stargardt Disease and RPGR-Associated Retinopathy.
PG  - 3608-3615
LID - 10.1167/iovs.17-21904 [doi]
AB  - Purpose: To assess reliability and repeatability of cone density measurements by 
      using confocal and (nonconfocal) split-detector adaptive optics scanning light
      ophthalmoscopy (AOSLO) imaging. It will be determined whether cone density values
      are significantly different between modalities in Stargardt disease (STGD) and
      retinitis pigmentosa GTPase regulator (RPGR)-associated retinopathy. Methods:
      Twelve patients with STGD (aged 9-52 years) and eight with RPGR-associated
      retinopathy (aged 11-31 years) were imaged using both confocal and split-detector
      AOSLO simultaneously. Four graders manually identified cone locations in each
      image that were used to calculate local densities. Each imaging modality was
      evaluated independently. The data set consisted of 1584 assessments of 99 STGD
      images (each image in two modalities and four graders who graded each image
      twice) and 928 RPGR assessments of 58 images (each image in two modalities and
      four graders who graded each image twice). Results: For STGD assessments the
      reliability for confocal and split-detector AOSLO was 67.9% and 95.9%,
      respectively, and the repeatability was 71.2% and 97.3%, respectively. The
      differences in the measured cone density values between modalities were
      statistically significant for one grader. For RPGR assessments the reliability
      for confocal and split-detector AOSLO was 22.1% and 88.5%, respectively, and
      repeatability was 63.2% and 94.5%, respectively. The differences in cone density 
      between modalities were statistically significant for all graders. Conclusions:
      Split-detector AOSLO greatly improved the reliability and repeatability of cone
      density measurements in both disorders and will be valuable for natural history
      studies and clinical trials using AOSLO. However, it appears that these indices
      may be disease dependent, implying the need for similar investigations in other
      conditions.
FAU - Tanna, Preena
AU  - Tanna P
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom.
FAU - Kasilian, Melissa
AU  - Kasilian M
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom.
FAU - Strauss, Rupert
AU  - Strauss R
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom 3Department of Ophthalmology,
      Medical University Graz and Johannes Kepler University, Linz, Austria 4Department
      of Ophthalmology, University of Basel, Basel, Switzerland.
FAU - Tee, James
AU  - Tee J
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom.
FAU - Kalitzeos, Angelos
AU  - Kalitzeos A
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom.
FAU - Tarima, Sergey
AU  - Tarima S
AD  - Division of Biostatistics, Institute for Health and Society, Medical College of
      Wisconsin, Milwaukee, Wisconsin, United States.
FAU - Visotcky, Alexis
AU  - Visotcky A
AD  - Division of Biostatistics, Institute for Health and Society, Medical College of
      Wisconsin, Milwaukee, Wisconsin, United States.
FAU - Dubra, Alfredo
AU  - Dubra A
AD  - Byers Eye Institute, Stanford University, Palo Alto, California, United States.
FAU - Carroll, Joseph
AU  - Carroll J
AD  - Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin,
      Milwaukee, Wisconsin, United States 8Department of Cell Biology, Neurobiology and
      Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
      9Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin,
      United States.
FAU - Michaelides, Michel
AU  - Michaelides M
AD  - UCL Institute of Ophthalmology, University College London, London, United Kingdom
      2Moorfields Eye Hospital, London, United Kingdom.
LA  - eng
GR  - R01 EY025231/EY/NEI NIH HHS/United States
GR  - R01 EY017607/EY/NEI NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
GR  - U01 EY025477/EY/NEI NIH HHS/United States
GR  - P30 EY001931/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Eye Proteins)
RN  - 0 (RPGR protein, human)
RN  - Stargardt disease 1
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cell Count
MH  - Child
MH  - Eye Proteins/*metabolism
MH  - Female
MH  - Humans
MH  - Macular Degeneration/*congenital/diagnosis
MH  - Male
MH  - Microscopy, Confocal
MH  - Middle Aged
MH  - Observer Variation
MH  - Ophthalmoscopy
MH  - Reproducibility of Results
MH  - Retinal Cone Photoreceptor Cells/*pathology
MH  - Retinitis Pigmentosa/*diagnosis/metabolism
MH  - Tomography, Optical Coherence
PMC - PMC5525557
EDAT- 2017/07/25 06:00
MHDA- 2017/07/29 06:00
CRDT- 2017/07/25 06:00
AID - 2645841 [pii]
AID - 10.1167/iovs.17-21904 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3608-3615. doi:
      10.1167/iovs.17-21904.