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PMID- 28738793
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170802
LR  - 20170802
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Jul 24
TI  - Association between 28 single nucleotide polymorphisms and type 2 diabetes
      mellitus in the Kazakh population: a case-control study.
PG  - 76
LID - 10.1186/s12881-017-0443-2 [doi]
AB  - BACKGROUND: We evaluated the associations between single nucleotide polymorphisms
      and different clinical parameters related to type 2 diabetes mellitus (T2DM),
      obesity risk, and metabolic syndrome (MS) in a Kazakh cohort. METHODS: A total of
      1336 subjects, including 408 T2DM patients and 928 control subjects, were
      recruited from an outpatient clinic and genotyped for 32 polymorphisms previously
      associated with T2DM and obesity-related phenotypes in other ethnic groups. For
      association studies, the chi-squared test or Fisher's exact test for binomial
      variables were used. Logistic regression was conducted to explore associations
      between the studied SNPs and the risk of developing T2DM, obesity, and MS, after 
      adjustments for age and sex. RESULTS: After excluding four SNPs due to
      Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts
      were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634
      (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2). In addition,
      examination of general unmatched T2DM and control cohorts revealed significant
      associations between T2DM and SNPsrs1799883 (FABP2) and rs9939609 (FTO).
      Furthermore, polymorphisms in the FTO gene were associated with increased obesity
      risk, whereas polymorphisms in the FTO and FABP2 genes were also associated with 
      the risk of developing MS in general unmatched cohorts. CONCLUSION: We confirmed 
      associations between polymorphisms within the SLC30A8, TSPAN8/LGR5, FABP2, and
      FTO genes and susceptibility to T2DM in a Kazakh cohort, and revealed significant
      associations with anthropometric and metabolic traits. In particular, FTO and
      FABP2 gene polymorphisms were significantly associated with susceptibility to MS 
      and obesity in this cohort.
FAU - Sikhayeva, Nurgul
AU  - Sikhayeva N
AUID- ORCID: http://orcid.org/0000-0001-6419-9483
AD  - National Center for Biotechnology, 13/5 Korgalzhyn str, Astana, 010000,
      Kazakhstan. [email protected]
AD  - L.N. Gumilyov Eurasian National University, Astana, Kazakhstan.
      [email protected]
FAU - Iskakova, Aisha
AU  - Iskakova A
AD  - National Center for Biotechnology, 13/5 Korgalzhyn str, Astana, 010000,
      Kazakhstan.
FAU - Saigi-Morgui, Nuria
AU  - Saigi-Morgui N
AD  - Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric 
      Neuroscience, Department of Psychiatry, Lausanne University Hospital, 1008,
      Prilly-Lausanne, Switzerland.
FAU - Zholdybaeva, Elena
AU  - Zholdybaeva E
AD  - National Center for Biotechnology, 13/5 Korgalzhyn str, Astana, 010000,
      Kazakhstan.
FAU - Eap, Chin-Bin
AU  - Eap CB
AD  - Unit of Pharmacogenetics and Clinical Psychopharmacology, Centre for Psychiatric 
      Neuroscience, Department of Psychiatry, Lausanne University Hospital, 1008,
      Prilly-Lausanne, Switzerland.
AD  - School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 
      Geneva, Switzerland.
FAU - Ramanculov, Erlan
AU  - Ramanculov E
AD  - National Center for Biotechnology, 13/5 Korgalzhyn str, Astana, 010000,
      Kazakhstan.
AD  - L.N. Gumilyov Eurasian National University, Astana, Kazakhstan.
AD  - School of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
LA  - eng
PT  - Journal Article
DEP - 20170724
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (FABP2 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics
MH  - Asian Continental Ancestry Group
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Ethnic Groups
MH  - Fatty Acid-Binding Proteins/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Kazakhstan
MH  - Male
MH  - Metabolic Syndrome X/*genetics/pathology
MH  - Middle Aged
MH  - Obesity/*genetics/pathology
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC5525290
OTO - NOTNLM
OT  - Genetic variants
OT  - Kazakh cohort
OT  - Metabolic syndrome
OT  - Obesity
OT  - Type 2 diabetes mellitus
EDAT- 2017/07/26 06:00
MHDA- 2017/08/03 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/04/10 [received]
PHST- 2017/07/13 [accepted]
AID - 10.1186/s12881-017-0443-2 [doi]
AID - 10.1186/s12881-017-0443-2 [pii]
PST - epublish
SO  - BMC Med Genet. 2017 Jul 24;18(1):76. doi: 10.1186/s12881-017-0443-2.