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Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of the NF-κB Signaling Pathway in DMBA-treated Hamsters.

Abstract The aim of this study was to investigate the effects of the flavonoid quercetin on chemoprevention of oral squamous cell carcinoma (OSCC). The study involved molecular signaling pathways in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis.
PMID
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Authors

Mayor MeshTerms
Keywords

7,12-dimethylbenz(a)anthracene (DMBA)

NF-κB

chemoprevention

hamster

oral squamous cell carcinoma

quercetin

Journal Title anticancer research
Publication Year Start




PMID- 28739686
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170810
LR  - 20170810
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Chemoprevention by Quercetin of Oral Squamous Cell Carcinoma by Suppression of
      the NF-kappaB Signaling Pathway in DMBA-treated Hamsters.
PG  - 4041-4049
AB  - BACKGROUND/AIM: The aim of this study was to investigate the effects of the
      flavonoid quercetin on chemoprevention of oral squamous cell carcinoma (OSCC).
      The study involved molecular signaling pathways in 7,12-dimethylbenz(a)
      anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. MATERIALS
      AND METHODS: DMBA (0.5%) was painted at the right buccal pouches of hamsters for 
      14 weeks to induce carcinoma. DMBA-treated hamsters received simultaneous doses
      of quercetin. Animals without DMBA induction were used as normal controls. The
      incidence of OSCC and the severity of pre-malignant lesions were determined
      histologically. Apoptosis in the pouch tissue was determined by TUNEL staining.
      The mRNA and protein expression of NF-kappaB p50 and p65, as well as Bcl-2 and
      Bax genes were analyzed using RT-PCR and Western blotting, respectively. RESULTS:
      Quercetin, at various doses, significantly reduced OSCC incidence and severity of
      hyperplasia and dysplasia compared to the DMBA-induction-only group (p<0.01).
      Apoptosis was induced by quercetin treatment compared to the DMBA-induction-only 
      group (p<0.01). mRNA and protein expression of NF-kappaB p50, p65 as well as
      Bcl-2 genes were significantly suppressed by quercetin at high doses compared to 
      DMBA induction only (p<0.05). However, mRNA and protein expression of the Bax
      gene was increased by quercetin treatment at medium and high doses, compared to
      the DMBA-induction-only group (p<0.05). Quercetin significantly reduced
      body-weight loss compared to the DMBA-induction-only group (p<0.05). CONCLUSION: 
      Quercetin reduced tumor incidence and induced apoptosis through modulation of
      NF-kappaB signaling and its target genes Bcl-2 and Bax in the DMBA-induced
      carcigenesis hamster model, suggesting the potential of quercetin as a candidate 
      for OSCC chemoprevention.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Zhang, Wen
AU  - Zhang W
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing,
      P.R. China.
AD  - Department of Oral Medicine, Affiliated Hospital of Stomatology, Nanjing Medical 
      University, Nanjing, P.R. China.
FAU - Yin, Gang
AU  - Yin G
AD  - Nanjing University of Chinese Medicine, Nanjing, P.R. China.
FAU - Dai, Jianguo
AU  - Dai J
AD  - Nanjing University of Chinese Medicine, Nanjing, P.R. China.
FAU - Sun, Y U
AU  - Sun YU
AD  - Origin Biosciences Inc., Nanjing, P.R. China.
FAU - Hoffman, Robert M
AU  - Hoffman RM
AD  - AntiCancer Inc., San Diego, CA, U.S.A.
AD  - Department of Surgery, University of California, San Diego, CA, U.S.A.
FAU - Yang, Zhijian
AU  - Yang Z
AD  - Origin Biosciences Inc., Nanjing, P.R. China.
FAU - Fan, Yuan
AU  - Fan Y
AD  - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing,
      P.R. China [email protected]
AD  - Department of Oral Medicine, Affiliated Hospital of Stomatology, Nanjing Medical 
      University, Nanjing, P.R. China.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (NF-kappa B)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene/toxicity
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Carcinogenesis/drug effects
MH  - Carcinoma, Squamous Cell/chemically induced/*drug therapy/genetics/pathology
MH  - Cricetinae
MH  - Disease Models, Animal
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Mouth Neoplasms/chemically induced/*drug therapy/genetics/pathology
MH  - NF-kappa B/*genetics
MH  - Proto-Oncogene Proteins c-bcl-2/biosynthesis/genetics
MH  - Quercetin/*administration & dosage
MH  - Signal Transduction/drug effects
MH  - bcl-2-Associated X Protein/biosynthesis/genetics
OTO - NOTNLM
OT  - 7,12-dimethylbenz(a)anthracene (DMBA)
OT  - NF-kappaB
OT  - chemoprevention
OT  - hamster
OT  - oral squamous cell carcinoma
OT  - quercetin
EDAT- 2017/07/26 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/22 [received]
PHST- 2017/06/04 [revised]
PHST- 2017/06/14 [accepted]
AID - 37/8/4041 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4041-4049.