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LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells.

Abstract Lipid rafts are cholesterol-enriched microdomains of the plasma membrane. Recent studies have underlined that their integrity is critical for cancer cell survival. Liver X receptor (LXR) has a central role in cellular cholesterol homeostasis and its stimulation inhibits proliferation of several cancer cell lines. This study investigated whether LXR could modulate lipid rafts integrity and consequently alter proliferation of the MCF-7 breast cancer cell line.
PMID
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Authors

Mayor MeshTerms
Keywords

DHHC5

LXR

Lipid rafts

MCF-7

flotillin-2

Journal Title anticancer research
Publication Year Start




PMID- 28739689
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170810
LR  - 20170810
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast 
      Cancer Cells.
PG  - 4067-4073
AB  - BACKGROUND/AIM: Lipid rafts are cholesterol-enriched microdomains of the plasma
      membrane. Recent studies have underlined that their integrity is critical for
      cancer cell survival. Liver X receptor (LXR) has a central role in cellular
      cholesterol homeostasis and its stimulation inhibits proliferation of several
      cancer cell lines. This study investigated whether LXR could modulate lipid rafts
      integrity and consequently alter proliferation of the MCF-7 breast cancer cell
      line. MATERIALS AND METHODS: Effect of LXR agonist T0901317 on integrity of MCF-7
      lipid rafts was examined by studying the expression of rafts marker flotillin-2
      (FLOT2) and DHHC5, which palmitoylates FLOT2, and by studying the expression of
      phospho-Akt. RESULTS: We demonstrated that LXR stimulation decreases mRNA and
      protein expression of FLOT2 and DHHC5 in MCF-7 cells. LXR stimulation also
      reduces Akt phosphorylation and its localization at the plasma membrane.
      CONCLUSION: We showed, for the first time, that LXR regulates transcription of
      specific proteins of lipid rafts in a breast cancer model.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Carbonnelle, Delphine
AU  - Carbonnelle D
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France.
FAU - Luu, Trang H
AU  - Luu TH
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France.
FAU - Chaillou, Chloe
AU  - Chaillou C
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France.
FAU - Huvelin, Jean-Michel
AU  - Huvelin JM
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France.
FAU - Bard, Jean-Marie
AU  - Bard JM
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France.
AD  - ICO Rene Gauducheau, Unicancer, St Herblain, France.
FAU - Nazih, Hassan
AU  - Nazih H
AD  - Faculty of Pharmacy, EA 2160 MMS - <<Institut Universitaire Mer et Littoral>>,
      FR3473 CNRS, <<Centre de Recherche en Nutrition Humaine Ouest>> (CRNH Ouest), UBL
      Nantes University, Nantes, France [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Liver X Receptors)
RN  - 0 (Membrane Proteins)
RN  - 0 (Sulfonamides)
RN  - 0 (TO-901317)
RN  - 0 (flotillins)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.- (DHHC5 protein, human)
SB  - IM
MH  - Acyltransferases/*genetics
MH  - Apoptosis/drug effects
MH  - Biomarkers, Tumor/genetics
MH  - Breast Neoplasms/*drug therapy/genetics/pathology
MH  - Cell Proliferation/drug effects
MH  - Cell Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Hydrocarbons, Fluorinated/administration & dosage
MH  - Liver X Receptors/agonists/*biosynthesis/genetics
MH  - MCF-7 Cells
MH  - Membrane Microdomains/genetics/pathology
MH  - Membrane Proteins/*genetics
MH  - Phosphorylation
MH  - Sulfonamides/administration & dosage
OTO - NOTNLM
OT  - DHHC5
OT  - LXR
OT  - Lipid rafts
OT  - MCF-7
OT  - flotillin-2
EDAT- 2017/07/26 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/06/02 [received]
PHST- 2017/06/19 [revised]
PHST- 2017/06/20 [accepted]
AID - 37/8/4067 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4067-4073.