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Differences in Extracellular Matrix Composition and its Role in Invasion in Primary and Secondary Intracerebral Malignancies.

Abstract The most common malignant primary brain tumor is glioblastoma which infiltrates the peritumoral brain, while secondary brain metastases are well demarcated malignancies. Previous research has proved the pivotal role of the changes in the extracellular matrix (ECM) in cancer cell invasion.
PMID
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Authors

Mayor MeshTerms
Keywords

Glioblastoma

brain metastasis

expression

extracellular matrix

invasion

Journal Title anticancer research
Publication Year Start


 


PMID- 28739696
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170810
LR  - 20170810
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Differences in Extracellular Matrix Composition and its Role in Invasion in
      Primary and Secondary Intracerebral Malignancies.
PG  - 4119-4126
AB  - BACKGROUND/AIM: The most common malignant primary brain tumor is glioblastoma
      which infiltrates the peritumoral brain, while secondary brain metastases are
      well demarcated malignancies. Previous research has proved the pivotal role of
      the changes in the extracellular matrix (ECM) in cancer cell invasion. MATERIALS 
      AND METHODS: The mRNA expression of 40 ECM molecules was determined using qRT-PCR
      in 54 fresh-frozen glioblastoma and brain metastasis samples. Seventy-two samples
      were used to determine the levels of 20 ECM proteins. RESULTS: The mRNA and
      protein expression pattern of the studied tumors differs greatly. Linear
      discriminant analysis of mRNA expression identified samples based on their mRNA
      expression profile with 92.3% probability and highlighted the role of some
      molecules as their level greatly influenced sample identification. CONCLUSION:
      Different tumor types with different invasiveness differ in the composition of
      their ECM and this can be used to identify samples. Furthermore, some ECM
      molecules greatly contribute to tumor invasiveness and could be targets of
      anti-invasive oncotherapy.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Virga, Jozsef
AU  - Virga J
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Szemcsak, Csaba David
AU  - Szemcsak CD
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Remenyi-Puskar, Judit
AU  - Remenyi-Puskar J
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Toth, Judit
AU  - Toth J
AD  - Department of Oncology, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Hortobagyi, Tibor
AU  - Hortobagyi T
AD  - Department of Neuropathology, Institute of Pathology, MTA-DE Cerebrovascular and 
      Neurodegenerative Research Group, University of Debrecen, Debrecen, Hungary.
FAU - Csosz, Eva
AU  - Csosz E
AD  - Proteomics Core Facility, Department of Biochemistry and Molecular Biology,
      Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
FAU - Zahuczky, Gabor
AU  - Zahuczky G
AD  - UD-GenoMed Medical Genomic Technologies Research & Development Services Ltd.,
      Debrecen, Hungary.
FAU - Szivos, Laszlo
AU  - Szivos L
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Bognar, Laszlo
AU  - Bognar L
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary.
FAU - Klekner, Almos
AU  - Klekner A
AD  - Department of Neurosurgery, Clinical Centre, University of Debrecen, Debrecen,
      Hungary [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Biomarkers, Tumor/*biosynthesis/genetics
MH  - Brain Neoplasms/*genetics/pathology/secondary
MH  - Cerebellar Neoplasms/*genetics/pathology
MH  - Extracellular Matrix/genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Glioblastoma/*genetics/pathology
MH  - Humans
MH  - Male
MH  - Neoplasm Invasiveness/genetics
MH  - Neoplasm Metastasis
MH  - Neoplasm Proteins/*biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
OTO - NOTNLM
OT  - Glioblastoma
OT  - brain metastasis
OT  - expression
OT  - extracellular matrix
OT  - invasion
EDAT- 2017/07/26 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/06/06 [received]
PHST- 2017/06/27 [revised]
PHST- 2017/06/28 [accepted]
AID - 37/8/4119 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4119-4126.