PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28739743
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Role of Plexin B1 in a Breast Cancer Cohort of Pakistani Patients and its
      Contribution Towards Cancer Metastasis as Indicated by an In Vitro Model.
PG  - 4483-4488
AB  - BACKGROUND/AIM: In the current study, the role of plexin B1 in breast cancer
      metastasis was explored. MATERIALS AND METHODS: Freshly-excised tumours along
      with background tissues of affected patients (n=121) were collected from
      Pakistani hospitals and processed for RNA isolation and cDNA synthesis. Using
      quantitative polymerase chain reaction, expression of plexin B1 was evaluated and
      correlated with clinicopathological parameters. Furthermore, involvement of
      plexin B1 in metastasis was explored by generating gene knockdown in MDA-MB-231
      and MCF-7 breast cancer cells. RESULTS: Poorly-differentiated tumours showed low 
      plexin B1 expression in comparison to well-differentiated ones. Similarly,
      reduced plexin B1 expression correlated positively with advanced tumour stage and
      metastasis. Loss of plexin B1 significantly reduced cell adhesion in comparison
      with respective control cell lines (p<0.05). Knockdown of plexin B1 in MDA-MB-231
      cells led to a remarkable increase in cell motility in contrast to the respective
      control. CONCLUSION: Loss of plexin B1 expression might play a pivotal role in
      enhancing the metastatic potential of breast cancer cells.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Malik, Muhammad Faraz Arshad
AU  - Malik MFA
AD  - Cardiff University-Peking University Cancer Institute (CUPUCI), Cardiff
      University School of Medicine, Cardiff University, Cardiff, U.K.
AD  - Department of Biosciences, COMSATS-Institute of Information Technology,
      Islamabad, Pakistan.
FAU - Riaz, Syeda Kiran
AU  - Riaz SK
AD  - Cardiff University-Peking University Cancer Institute (CUPUCI), Cardiff
      University School of Medicine, Cardiff University, Cardiff, U.K.
FAU - Waqar, S H
AU  - Waqar SH
AD  - Shaheed Zulfiqar Ali Bhutto Medical University/Pakistan Institute of Medical
      Sciences, Islamabad, Pakistan.
FAU - Haq, Farhan
AU  - Haq F
AD  - Department of Biosciences, COMSATS-Institute of Information Technology,
      Islamabad, Pakistan.
FAU - Ye, Lin
AU  - Ye L
AD  - Cardiff University-Peking University Cancer Institute (CUPUCI), Cardiff
      University School of Medicine, Cardiff University, Cardiff, U.K.
FAU - Jiang, Wen G
AU  - Jiang WG
AD  - Cardiff University-Peking University Cancer Institute (CUPUCI), Cardiff
      University School of Medicine, Cardiff University, Cardiff, U.K.
      [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (PLXNB1 protein, human)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Breast Neoplasms/*genetics/*pathology
MH  - Cell Adhesion/genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Female
MH  - Gene Expression
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Nerve Tissue Proteins/*genetics
MH  - Receptors, Cell Surface/*genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Plexin B1
OT  - adhesion
OT  - breast cancer
OT  - metastasis
OT  - migration
OT  - qRT-PCR
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/06/01 [received]
PHST- 2017/06/16 [revised]
PHST- 2017/06/19 [accepted]
AID - 37/8/4483 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4483-4488.