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Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of Human Bladder Uroepithelium Cell Carcinoma.

Abstract Metastasis suppressor 1 (MTSS1) is a multi-functional cytoskeletal protein. Recent research showed that MTSS1 is a potential tumor suppressor in many types of cancer cells, including kidney and bladder cancer cells. However, the clinical implication of MTSS1 in human bladder uroepithelium cell carcinoma (BUCC) and its potential in suppressing BUCC tumorigenesis remains undetermined. In the present study, the expression of MTSS1 in human BUCC tissue samples, and correlations between MTSS1 and pathological grade and stage of the tumors were examined in BUCC specimens. The function of MTSS1 in BUCC progression was explored.
PMID
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Authors

Mayor MeshTerms

Gene Expression

Keywords

Metastasis suppressor-1

bladder uroepithelium cell carcinoma

cell cycle

proliferation

Journal Title anticancer research
Publication Year Start




PMID- 28739745
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of 
      Human Bladder Uroepithelium Cell Carcinoma.
PG  - 4499-4505
AB  - BACKGROUND: Metastasis suppressor 1 (MTSS1) is a multi-functional cytoskeletal
      protein. Recent research showed that MTSS1 is a potential tumor suppressor in
      many types of cancer cells, including kidney and bladder cancer cells. However,
      the clinical implication of MTSS1 in human bladder uroepithelium cell carcinoma
      (BUCC) and its potential in suppressing BUCC tumorigenesis remains undetermined. 
      In the present study, the expression of MTSS1 in human BUCC tissue samples, and
      correlations between MTSS1 and pathological grade and stage of the tumors were
      examined in BUCC specimens. The function of MTSS1 in BUCC progression was
      explored. MATERIALS AND METHODS: The mRNA and protein expression of MTSS1 were
      examined in 68 BUCC tissue samples with matching adjacent normal bladder tissues 
      using quantitative real-time PCR and western blotting. Furthermore, the bladder
      cancer cell line 5637 was used to determine the anticancer effect of MTSS1.
      RESULTS: Lower MTSS1 mRNA expression was recorded in BUCC tissues compared to
      normal bladder tissues. A lower MTSS1 mRNA level was observed in tumors with high
      clinical stage and with high pathological nuclear grade. Likewise, MTSS1 protein 
      expression in normal bladder tissue was significantly higher than that in BUCC
      tissue. The protein level of MTSS1 significantly negatively correlated with
      clinical stage and pathological nuclear grade of BUCC. Cumulative survival curves
      indicated that MTSS1 expression was negatively correlated with survival time:
      patients with a high level of MTSS1 had significantly longer survival time than
      those with a low level of MTSS1 (p<0.001). Overexpression of MTSS1 reduced BUCC
      cell proliferation, cell-cycle progression and colony formation, but had no
      influence on BUCC cell apoptosis. CONCLUSION: Overexpression of MTSS1 suppresses 
      BUCC development, providing a novel perspective for BUCC tumorigenesis and a
      potential therapeutic target for BUCC.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - DU, Peng
AU  - DU P
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Urology, Peking University Cancer Hospital & Institute,
      Beijing, P.R. China.
FAU - Wang, Shuo
AU  - Wang S
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Urology, Peking University Cancer Hospital & Institute,
      Beijing, P.R. China.
FAU - Tang, Xingxing
AU  - Tang X
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Urology, Peking University Cancer Hospital & Institute,
      Beijing, P.R. China.
FAU - An, Chao
AU  - An C
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Urology, Peking University Cancer Hospital & Institute,
      Beijing, P.R. China.
FAU - Yang, Yong
AU  - Yang Y
AD  - Key laboratory of Carcinogenesis and Translational Research (Ministry of
      Education), Department of Urology, Peking University Cancer Hospital & Institute,
      Beijing, P.R. China [email protected] [email protected]
FAU - Jiang, Wen G
AU  - Jiang WG
AD  - Cardiff China Medical Research Collaborative, Cardiff University School of
      Medicine, Cardiff, U.K. [email protected] [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (MTSS1 protein, human)
RN  - 0 (Microfilament Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis/genetics
MH  - Carcinoma/*genetics/metabolism/mortality/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation
MH  - Disease Progression
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - Male
MH  - Microfilament Proteins/*genetics/metabolism
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Proteins/*genetics/metabolism
MH  - Neoplasm Staging
MH  - Prognosis
MH  - RNA, Messenger/genetics/metabolism
MH  - Urinary Bladder Neoplasms/*genetics/metabolism/mortality/*pathology
OTO - NOTNLM
OT  - Metastasis suppressor-1
OT  - bladder uroepithelium cell carcinoma
OT  - cell cycle
OT  - proliferation
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/06/01 [received]
PHST- 2017/06/19 [revised]
PHST- 2017/06/21 [accepted]
AID - 37/8/4499 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4499-4505.