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Cyclosporin A Reversed Chemoresistance of a Patient with Pure Red Cell Aplasia Secondary to Thymoma.

Abstract This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered to treat aplasia, could reverse chemoresistance. Its mechanism is not completely clear, but the hypothesis of CsA inhibiting P-glycoprotein mediated drug efflux is the most acceptable.
PMID
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Authors

Mayor MeshTerms
Keywords

Cyclosporin A

chemoresistance

thymoma

Journal Title anticancer research
Publication Year Start




PMID- 28739760
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Cyclosporin A Reversed Chemoresistance of a Patient with Pure Red Cell Aplasia
      Secondary to Thymoma.
PG  - 4611-4614
AB  - CASE REPORT: This case study reports on a patient who relapsed with thymoma
      (mixed type) nine years after tumor resection. After four courses of rescue
      chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with 
      pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was
      administered to treat aplasia, could reverse chemoresistance. Its mechanism is
      not completely clear, but the hypothesis of CsA inhibiting P-glycoprotein
      mediated drug efflux is the most acceptable.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Li, Peng
AU  - Li P
AD  - Department of Oncology, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
FAU - DU, Fengcai
AU  - DU F
AD  - The First Clinical College of DaLian Medical University, DaLian, P.R. China.
FAU - Gong, Zhaohua
AU  - Gong Z
AD  - Department of Oncology, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
FAU - Hu, Baohong
AU  - Hu B
AD  - Department of Oncology, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
FAU - Chi, Cheng
AU  - Chi C
AD  - Department of Oncology, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
FAU - Chu, Hongjin
AU  - Chu H
AD  - The Central Laboratory, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
FAU - Chen, Jian
AU  - Chen J
AD  - Department of Oncology, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China [email protected]
AD  - The Central Laboratory, the Affiliated Yantai Yuhuangding Hospital of Qingdao
      University, Yantai, P.R. China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use
MH  - Cyclosporine/pharmacology/*therapeutic use
MH  - Drug Resistance, Neoplasm/*drug effects
MH  - Fatal Outcome
MH  - Humans
MH  - Immunosuppressive Agents/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Red-Cell Aplasia, Pure/diagnosis/*drug therapy/*etiology
MH  - Thymoma/*complications/diagnosis/drug therapy
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Cyclosporin A
OT  - chemoresistance
OT  - thymoma
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/19 [received]
PHST- 2017/06/13 [revised]
PHST- 2017/06/14 [accepted]
AID - 37/8/4611 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4611-4614.