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Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced Esophageal Carcinoma.

Abstract Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy.
PMID
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Authors

Mayor MeshTerms
Keywords

Esophageal cancer

Th17 cells

Treg cells

radiation pneumonia

radiotherapy

Journal Title anticancer research
Publication Year Start




PMID- 28739765
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Relationship of Th17/Treg Cells and Radiation Pneumonia in Locally Advanced
      Esophageal Carcinoma.
PG  - 4643-4647
AB  - BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the
      clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper
      cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in
      inflammatory diseases. The balance between Treg and Th17 cells is a key factor in
      the progression of many inflammatory and autoimmune diseases. Whether Tregs and
      Th17 cells are predictive factors of radiation pneumonia has not yet been
      reported. In this study, we investigated the relationships of Treg/Th17 cells and
      radiation pneumonia in patients with locally advanced esophageal cancer who
      received radiotherapy. PATIENTS AND METHODS: One hundred and forty-eight patients
      with locally advanced esophageal cancer who received radical and palliative
      radiotherapy were enrolled. The levels of Th17 and Treg cells in the blood of
      patients were detected using flow cytometry at the time point of
      pre-radiotherapy, 1st, 2nd, 3rd, 4th, 5th and 6th week from the start of
      radiation and 4 weeks after completion of radiotherapy. Radiation pneumonia was
      evaluated according to Radiation Therapy Oncology Group's acute radiation
      pneumonia standards, with the endpoint being grade 2 or above radiation
      pneumonia. RESULTS: There were 24 cases of radiation pneumonia in 148 cases of
      locally advanced esophageal cancer patients who underwent radiotherapy. Th17
      cells increased and, in contrast, Treg cells decreased in the radiation pneumonia
      group. The change in the ratio of Th17/Treg was more pronounced and the
      difference was statistically significant from the 5th week after irradiation
      compared to patients with no radiation pneumonia (p<0.05). There was no
      significant difference in dosimetric parameters, including V5, V20, V30 and mean 
      lung dose (MLD) and clinical factors, such as gender, age, smoking history,
      history of surgery and chemotherapy. CONCLUSION: The ratio of Th17/Treg cells may
      be an effective predictive factor of radiation pneumonia.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Radiation Oncology, Affiliated People's Hospital, Jiangsu
      University, Zhenjiang, P.R. China.
FAU - Xu, Gang
AU  - Xu G
AD  - Department of Radiation Oncology, Affiliated People's Hospital, Jiangsu
      University, Zhenjiang, P.R. China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Radiation Oncology, Affiliated People's Hospital, Jiangsu
      University, Zhenjiang, P.R. China.
FAU - Li, Xin-Hua
AU  - Li XH
AD  - Department of Radiation Oncology, Yuhuangding Hospital of Qingdao University,
      Yantai, P.R. China.
FAU - Sun, Ping
AU  - Sun P
AD  - Department of Radiation Oncology, Yuhuangding Hospital of Qingdao University,
      Yantai, P.R. China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Radiation Oncology, Yuhuangding Hospital of Qingdao University,
      Yantai, P.R. China.
FAU - Li, Jun-Xia
AU  - Li JX
AD  - Department of Radiation Oncology, Yuhuangding Hospital of Qingdao University,
      Yantai, P.R. China [email protected] [email protected]
FAU - Wu, Chao-Yang
AU  - Wu CY
AD  - Department of Radiation Oncology, Affiliated People's Hospital, Jiangsu
      University, Zhenjiang, P.R. China [email protected] [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Esophageal Neoplasms/*complications/diagnosis/*immunology/radiotherapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunophenotyping
MH  - Incidence
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Phenotype
MH  - Radiation Pneumonitis/diagnosis/epidemiology/*etiology
MH  - Risk Factors
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
MH  - Th17 Cells/*immunology/metabolism
OTO - NOTNLM
OT  - Esophageal cancer
OT  - Th17 cells
OT  - Treg cells
OT  - radiation pneumonia
OT  - radiotherapy
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/02 [received]
PHST- 2017/05/25 [revised]
PHST- 2017/05/26 [accepted]
AID - 37/8/4643 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4643-4647.