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Predictors of Malignancy for Female Patients with Suspicious Nipple Discharge: A Retrospective Study.

Abstract Suspicious nipple discharge (ND) in females requires further treatment, including biopsy or selective duct excision. It is important to identify predictors of malignancy in female patients with suspicious ND.
PMID
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Authors

Mayor MeshTerms

Nipple Discharge

Keywords

Predictors of malignancy

nipple discharge

Journal Title anticancer research
Publication Year Start




PMID- 28739767
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Predictors of Malignancy for Female Patients with Suspicious Nipple Discharge: A 
      Retrospective Study.
PG  - 4655-4658
AB  - BACKGROUND: Suspicious nipple discharge (ND) in females requires further
      treatment, including biopsy or selective duct excision. It is important to
      identify predictors of malignancy in female patients with suspicious ND.
      MATERIALS AND METHODS: This retrospective study included patients with suspicious
      ND who underwent surgical treatment at our center between January 2007 and
      December 2014. Clinicopathological features were compared between patients with
      and without malignancy. We used a Chi-square test and a logistic regression model
      as the univariate and multivariate analysis for identification of predictors of
      malignancy. RESULTS: A total of 334 patients were eligible and included. The
      median age of the study population was 45 (range=19-81) years; 18.0% (60/334) of 
      the entire study population had breast cancer. The univariate analysis suggested 
      that older age (p=0.002) and presence of suspicious lumps (p<0.001) were
      significantly associated with malignancy. In contrast, presence of bloody
      discharge was not significantly associated with malignancy (p=0.324). The
      multivariate analysis confirmed that older age (p=0.023) and presence of
      suspicious lumps (p<0.001) were independent predictors of malignancy. For
      patients without suspicious lumps, we did not observe any association between the
      presence of bloody discharge and malignancy. For patients with suspicious lumps, 
      tumor size was significantly associated with malignancy (p<0.001). CONCLUSION:
      Our study suggests that older age and the presence of suspicious lumps are
      predictors of the presence of malignancy in females with suspicious ND.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Jin, Liang
AU  - Jin L
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China.
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
FAU - Zhu, Liling
AU  - Zhu L
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China.
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
FAU - Li, Shunrong
AU  - Li S
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China.
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
FAU - Zeng, Yinduo
AU  - Zeng Y
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China.
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
FAU - Haixiong, Lin
AU  - Haixiong L
AD  - Department of Clinical Laboratory, Sun Yat-Sen University Memorial Hospital, Sun 
      Yat-Sen University, Guangzhou, P.R. China.
FAU - Su, Fengxi
AU  - Su F
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China [email protected] [email protected]
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
FAU - Chen, Kai
AU  - Chen K
AD  - Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene
      Regulation, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen University,
      Guangzhou, P.R. China [email protected] [email protected]
AD  - Breast Tumor Center, Sun Yat-Sen University Memorial Hospital, Sun Yat-Sen
      University, Guangzhou, P.R. China.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biopsy
MH  - Breast Diseases/*diagnosis/pathology/therapy
MH  - Female
MH  - Humans
MH  - Mammography
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - *Nipple Discharge
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Predictors of malignancy
OT  - nipple discharge
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/02 [received]
PHST- 2017/06/05 [revised]
PHST- 2017/06/06 [accepted]
AID - 37/8/4655 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4655-4658.