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Clinical Characteristics and Prognosis of Elderly Small Cell Lung Cancer Patients Complicated with Hyponatremia: A Retrospective Analysis.

Abstract This study was designed to evaluate the clinical characteristics and prognosis of elderly small cell lung cancer (SCLC) patients complicated with hyponatremia, thus providing increased attention for appropriate intervention and improving outcomes in symptomatic subjects.
PMID
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Authors

Mayor MeshTerms
Keywords

Small cell lung cancer

elderly patients

hyponatremia

prognosis

Journal Title anticancer research
Publication Year Start




PMID- 28739771
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170803
LR  - 20170803
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 8
DP  - 2017 Aug
TI  - Clinical Characteristics and Prognosis of Elderly Small Cell Lung Cancer Patients
      Complicated with Hyponatremia: A Retrospective Analysis.
PG  - 4681-4686
AB  - AIM: This study was designed to evaluate the clinical characteristics and
      prognosis of elderly small cell lung cancer (SCLC) patients complicated with
      hyponatremia, thus providing increased attention for appropriate intervention and
      improving outcomes in symptomatic subjects. PATIENTS AND METHODS: The clinical
      data of 320 patients with SCLC in the Yuhuangding Hospital from March 1st, 2006, 
      to March 1st, 2012, were studied retrospectively. The prognosis and possible
      association with hyponatremia was investigated. RESULTS: The incidence rate of
      hyponatremia in SCLC was 46.56% (149/320). The mean survival time was 1.10+/-0.42
      years in patients with normal values and 0.83+/-0.35 years in patients with
      subnormal serum sodium. In the hyponatremia group, the mean survival time of
      corrected hyponatremia patients was 0.91+/-0.42 years, which was significantly
      longer than uncorrected hyponatremia patients whose mean survival time was
      0.68+/-0.26 years (t=2.75, p<0.05) after symptomatic treatment. The mean survival
      time of the normal group and the hyponatremia group in elderly patients had a
      tendency to decrease when compared to another group of patients younger than 60
      years old. Hyponatremia at 1- and 3-year follow-up was associated with worse
      survival rates (p<0.05). CONCLUSION: The severity of hyponatremia has unfavorable
      prognostic impacts. Elderly SCLC patients with hyponatremia are difficult to cure
      and associated with significantly shorter survival, especially in the uncorrected
      group. It is important that the cause of the hyponatremia is diagnosed at an
      early stage and precise medical treatment is provided.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Yang, Yongping
AU  - Yang Y
AD  - Nursing Department, Yantai Yantaishan Hospital, Yantai, P.R. China.
FAU - Sun, Naihong
AU  - Sun N
AD  - Yantai Central Blood Station, Yantai, P.R. China.
FAU - Sun, Ping
AU  - Sun P
AD  - Department of Oncology, Yantai Yuhuangding Hospital, Affiliated with Medical
      College of Qingdao University, Yantai, P.R. China [email protected]
FAU - Zhang, Liangming
AU  - Zhang L
AD  - Department of Oncology, Yantai Yuhuangding Hospital, Affiliated with Medical
      College of Qingdao University, Yantai, P.R. China [email protected]
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Combined Modality Therapy
MH  - Disease Management
MH  - Female
MH  - Humans
MH  - Hyponatremia/*diagnosis/*etiology/mortality/therapy
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*complications/*mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Small Cell Lung Carcinoma/*complications/*mortality/therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Small cell lung cancer
OT  - elderly patients
OT  - hyponatremia
OT  - prognosis
EDAT- 2017/07/26 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/26 06:00
PHST- 2017/05/19 [received]
PHST- 2017/06/08 [revised]
PHST- 2017/06/09 [accepted]
AID - 37/8/4681 [pii]
PST - ppublish
SO  - Anticancer Res. 2017 Aug;37(8):4681-4686.