PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Evolutionary changes in the capsid P2 region of Australian strains of the norovirus GII.Pe_GII.4.

Abstract The protruding (P) 2 region of the norovirus capsid is thought to include hypervariable sites involved in receptor binding. This study examines the changes that occurred in the P2 region of GII.Pe_GII.4 norovirus in the course of its evolution from a precursor phase (2008-2009), to an intermediate phase (2010) and finally to an epidemic phase (2012-2015).
PMID
Related Publications

Structural Evolution of the Emerging 2014-2015 GII.17 Noroviruses.

Novel GII.12 norovirus strain, United States, 2009-2010.

Genetic analysis of the capsid region of norovirus GII.4 variants isolated in South Korea.

Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period.

Norovirus GII.4 and GII.7 capsid sequences undergo positive selection in chronically infected patients.

Authors

Mayor MeshTerms

Evolution, Molecular

Genetic Variation

Keywords
Journal Title journal of medical microbiology
Publication Year Start




PMID- 28742004
OWN - NLM
STAT- MEDLINE
DA  - 20170725
DCOM- 20170809
LR  - 20170809
IS  - 1473-5644 (Electronic)
IS  - 0022-2615 (Linking)
VI  - 66
IP  - 7
DP  - 2017 Jul
TI  - Evolutionary changes in the capsid P2 region of Australian strains of the
      norovirus GII.Pe_GII.4.
PG  - 1014-1022
LID - 10.1099/jmm.0.000531 [doi]
AB  - PURPOSE: The protruding (P) 2 region of the norovirus capsid is thought to
      include hypervariable sites involved in receptor binding. This study examines the
      changes that occurred in the P2 region of GII.Pe_GII.4 norovirus in the course of
      its evolution from a precursor phase (2008-2009), to an intermediate phase (2010)
      and finally to an epidemic phase (2012-2015). METHODOLOGY: Twenty-two P2 region
      amino acid (aa) sequences (166 aa long) from all phases of the evolution of the
      virus were compared and the changes analysed.Results/key findings. Twenty sites
      in the P2 region underwent aa change and of these, 10 corresponded to previously 
      proposed hypervariable sites and 10 to novel hypervariable sites. It was notable 
      that aa changes at two sites, X and Y, only emerged as the epidemic phase
      progressed. 3D computer modelling of the P2 region indicated that neither X nor Y
      were in the uppermost 'crown', but further down in the 'neck' portion. The
      location of X and Y and the nature of aa change at Y suggest these sites were
      important in enhancing the structural integrity of the capsid, which in turn may 
      have facilitated the longer term viability of the virus. CONCLUSION: The current 
      study helps establish the validity of previously proposed hypervariable sites in 
      the P2 region as well as indicating new ones. It also provides quantitative and
      qualitative data on how these sites changed over the evolutionary history of a
      particular norovirus strain.
FAU - Bruggink, Leesa D
AU  - Bruggink LD
AD  - Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria,
      Australia.
FAU - Moselen, Jean M
AU  - Moselen JM
AD  - Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria,
      Australia.
FAU - Roberts, Jason A
AU  - Roberts JA
AD  - Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria,
      Australia.
FAU - Marshall, John A
AU  - Marshall JA
AD  - Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria,
      Australia.
LA  - eng
PT  - Journal Article
DEP - 20170721
PL  - England
TA  - J Med Microbiol
JT  - Journal of medical microbiology
JID - 0224131
RN  - 0 (Capsid Proteins)
SB  - IM
MH  - Australia
MH  - Caliciviridae Infections/*virology
MH  - Capsid Proteins/*genetics
MH  - *Evolution, Molecular
MH  - *Genetic Variation
MH  - Humans
MH  - Norovirus/*classification/*genetics/isolation & purification
MH  - Sequence Analysis, DNA
EDAT- 2017/07/26 06:00
MHDA- 2017/08/10 06:00
CRDT- 2017/07/26 06:00
AID - 10.1099/jmm.0.000531 [doi]
PST - ppublish
SO  - J Med Microbiol. 2017 Jul;66(7):1014-1022. doi: 10.1099/jmm.0.000531. Epub 2017
      Jul 21.