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Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina.

Abstract Simultaneous stimulation of multiple retinal electrodes in normally sighted animals shows promise in improving the resolution of retinal prostheses. However, the effects of simultaneous stimulation on degenerate retinae remain unknown. Therefore, we investigated the characteristics of cortical responses to multielectrode stimulation of the degenerate retina.
PMID
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Authors

Mayor MeshTerms

Visual Prosthesis

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28744551
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170811
LR  - 20170811
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 9
DP  - 2017 Jul 01
TI  - Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina.
PG  - 3770-3784
LID - 10.1167/iovs.16-21290 [doi]
AB  - Purpose: Simultaneous stimulation of multiple retinal electrodes in normally
      sighted animals shows promise in improving the resolution of retinal prostheses. 
      However, the effects of simultaneous stimulation on degenerate retinae remain
      unknown. Therefore, we investigated the characteristics of cortical responses to 
      multielectrode stimulation of the degenerate retina. Methods: Four adult cats
      were bilaterally implanted with retinal electrode arrays in the suprachoroidal
      space after unilateral adenosine triphosphate (ATP)-induced retinal photoreceptor
      degeneration. Functional and structural changes were characterized by using
      electroretinogram a-wave amplitude and optical coherence tomography. Multiunit
      activity was recorded from both hemispheres of the visual cortex. Responses to
      single- and multielectrode stimulation of the ATP-injected and fellow control
      eyes were characterized and compared. Results: The retinae of ATP-injected eyes
      displayed structural and functional changes consistent with mid- to late-stage
      photoreceptor degeneration and remodeling. Responses to multielectrode
      stimulation of the ATP-injected eyes exhibited shortened latencies, lower
      saturated spike counts, and higher thresholds, compared to stimulation of the
      fellow control eyes. Electrical receptive field sizes were significantly larger
      in the ATP-injected eye than in the control eye, and positively correlated with
      the extent of degeneration. Conclusions: Significant differences exist between
      cortical responses to stimulation of healthy and degenerate retinae. Our results 
      highlight the importance of using a retinal degeneration model when evaluating
      the efficacy of novel stimulation paradigms.
FAU - Halupka, Kerry J
AU  - Halupka KJ
AD  - NeuroEngineering Laboratory, Department of Biomedical Engineering, The University
      of Melbourne, Victoria, Australia 2Data61, Commonwealth Scientific and Industrial
      Research Organisation (CSIRO), New South Wales, Australia 3Bionics Institute,
      East Melbourne, Victoria, Australia.
FAU - Abbott, Carla J
AU  - Abbott CJ
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital;
      Department of Surgery (Ophthalmology), The University of Melbourne, Victoria,
      Australia.
FAU - Wong, Yan T
AU  - Wong YT
AD  - Department of Physiology, Monash University, Victoria, Australia 6Department of
      Electrical and Computer Systems Engineering, Monash University, Victoria,
      Australia.
FAU - Cloherty, Shaun L
AU  - Cloherty SL
AD  - Department of Physiology, Monash University, Victoria, Australia 7National Vision
      Research Institute, Australian College of Optometry, Victoria, Australia.
FAU - Grayden, David B
AU  - Grayden DB
AD  - NeuroEngineering Laboratory, Department of Biomedical Engineering, The University
      of Melbourne, Victoria, Australia 3Bionics Institute, East Melbourne, Victoria,
      Australia 8Centre for Neural Engineering, The University of Melbourne, Victoria, 
      Australia.
FAU - Burkitt, Anthony N
AU  - Burkitt AN
AD  - NeuroEngineering Laboratory, Department of Biomedical Engineering, The University
      of Melbourne, Victoria, Australia 3Bionics Institute, East Melbourne, Victoria,
      Australia.
FAU - Sergeev, Evgeni N
AU  - Sergeev EN
AD  - NeuroEngineering Laboratory, Department of Biomedical Engineering, The University
      of Melbourne, Victoria, Australia.
FAU - Luu, Chi D
AU  - Luu CD
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital;
      Department of Surgery (Ophthalmology), The University of Melbourne, Victoria,
      Australia.
FAU - Brandli, Alice
AU  - Brandli A
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital;
      Department of Surgery (Ophthalmology), The University of Melbourne, Victoria,
      Australia.
FAU - Allen, Penelope J
AU  - Allen PJ
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital;
      Department of Surgery (Ophthalmology), The University of Melbourne, Victoria,
      Australia.
FAU - Meffin, Hamish
AU  - Meffin H
AD  - National Vision Research Institute, Australian College of Optometry, Victoria,
      Australia 9Australian Research Council Centre of Excellence for Integrative Brain
      Function, Department of Optometry and Vision Sciences, The University of
      Melbourne, Melbourne, Victoria, Australia.
FAU - Shivdasani, Mohit N
AU  - Shivdasani MN
AD  - Bionics Institute, East Melbourne, Victoria, Australia 10Department of Medical
      Bionics, The University of Melbourne, Victoria, Australia.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/toxicity
MH  - Animals
MH  - Cats
MH  - Disease Models, Animal
MH  - Electric Stimulation/*methods
MH  - Electrodes, Implanted
MH  - Electroretinography
MH  - Evoked Potentials, Visual/*physiology
MH  - Photic Stimulation
MH  - Photoreceptor Cells, Vertebrate/*physiology
MH  - Retinal Degeneration/chemically induced/diagnosis/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Visual Cortex/*physiology
MH  - *Visual Prosthesis
EDAT- 2017/07/27 06:00
MHDA- 2017/08/12 06:00
CRDT- 2017/07/27 06:00
AID - 2646456 [pii]
AID - 10.1167/iovs.16-21290 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3770-3784. doi:
      10.1167/iovs.16-21290.