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Serum vaspin level as a predictive indicator in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty.

Abstract This study is all about predicting the value of serum vaspin level in the amelioration of fatty liver and metabolic disturbance in patients with severe obesity after laparoscopic vertical banded gastroplasty (LVBG).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28746192
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - Serum vaspin level as a predictive indicator in the amelioration of fatty liver
      and metabolic disturbance in patients with severe obesity after laparoscopic
      vertical banded gastroplasty.
PG  - e7498
LID - 10.1097/MD.0000000000007498 [doi]
AB  - BACKGROUND: This study is all about predicting the value of serum vaspin level in
      the amelioration of fatty liver and metabolic disturbance in patients with severe
      obesity after laparoscopic vertical banded gastroplasty (LVBG). METHODS: A total 
      of 164 patients (from January 2012 to May 2015) with severe obesity were chosen
      and performed LVBG. Enzyme-linked immunosorbent assay was performed to detect the
      serum vaspin level. The patients were given a biochemical automatic analyzer to
      measure the biochemical indicators. Homeostasis model assessment (HOMA) helps in 
      the calculation of fasting insulin level (FINS) and insulin resistance (IR). The 
      changes in fatty liver were examined by computed tomography (CT). Receiver
      operating characteristic curve is used to increase the predictive value of serum 
      vaspin level in the amelioration of liver function and disturbances in the
      metabolism. RESULTS: Weight, BMI, waist circumference, serum vaspin level, and
      triglyceride (TG) decreased, but CT value of liver increased at 4th, 7th, and
      12th month after surgery. After the 7th and 12th month period of surgery, the
      alanine aminotransferase, aspartate aminotransferase, FINS, and HOMA-IR reduced
      in the patients (P <.005). The area under ROC curve (AUC) is about 0.871 +/-
      0.031 with 95%CI of 0.810-0.931 (P <.001). The sensitivity, specificity, and
      accuracy of serum vaspin level </=0.9 were 87.80%, 78.05%, and 83.28%,
      respectively. BMI, FINS, and serum vaspin level </=0.9 were the influencing
      factors of the amelioration of fatty liver and metabolic disturbance. CONCLUSION:
      This study proves that the serum vaspin level serves as a predictive indicator in
      the amelioration of fatty liver and metabolic disturbance in patients with severe
      obesity after LVBG.
FAU - Wang, Yong
AU  - Wang Y
AD  - Department of General Surgery, The Second Hospital of Anhui Medical University,
      Hefei, Anhui Province, People's Republic of China.
FAU - Yu, Zong-Fan
AU  - Yu ZF
FAU - Cheng, Yun-Sheng
AU  - Cheng YS
FAU - Jia, Ben-Li
AU  - Jia BL
FAU - Yu, Gang
AU  - Yu G
FAU - Yin, Xiao-Qiang
AU  - Yin XQ
FAU - Wang, Yang
AU  - Wang Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Insulin)
RN  - 0 (SERPINA12 protein, human)
RN  - 0 (Serpins)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Body Weight
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fasting
MH  - Fatty Liver/complications/diagnostic imaging/*metabolism/*surgery
MH  - Female
MH  - Gastroplasty
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Laparoscopy
MH  - Liver/diagnostic imaging
MH  - Logistic Models
MH  - Male
MH  - Obesity, Morbid/complications/*metabolism/*surgery
MH  - Prognosis
MH  - ROC Curve
MH  - Serpins/*blood
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007498 [doi]
AID - 00005792-201707280-00023 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7498. doi: 10.1097/MD.0000000000007498.