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The immediate effect of facial candling on inflammatory mediators, substance P, symptoms severity, and quality of life in allergic rhinitis patients: Study protocol for a randomized controlled trial.

Abstract Asian countries have a variety of ethnic groups and culture that provide their own traditional treatment in health care. Facial candling appears to be one of the popular traditional treatments in Southeast Asian. The complementary medicine practitioners promote that the facial candling treatment would help in reducing the symptoms of allergic rhinitis and other problems related to sinus. Due to the lack of evidence available, the effectiveness of this treatment method and its mechanism, however, remains unknown. The objective of this research is therefore to study impact of facial candling on inflammatory mediators, substance P (SP), symptoms severity, and quality of life (QoL) in allergic rhinitis patients.
PMID
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Authors

Mayor MeshTerms

Medicine, East Asian Traditional

Keywords
Journal Title medicine
Publication Year Start




PMID- 28746195
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - The immediate effect of facial candling on inflammatory mediators, substance P,
      symptoms severity, and quality of life in allergic rhinitis patients: Study
      protocol for a randomized controlled trial.
PG  - e7511
LID - 10.1097/MD.0000000000007511 [doi]
AB  - INTRODUCTION: Asian countries have a variety of ethnic groups and culture that
      provide their own traditional treatment in health care. Facial candling appears
      to be one of the popular traditional treatments in Southeast Asian. The
      complementary medicine practitioners promote that the facial candling treatment
      would help in reducing the symptoms of allergic rhinitis and other problems
      related to sinus. Due to the lack of evidence available, the effectiveness of
      this treatment method and its mechanism, however, remains unknown. The objective 
      of this research is therefore to study impact of facial candling on inflammatory 
      mediators, substance P (SP), symptoms severity, and quality of life (QoL) in
      allergic rhinitis patients. METHOD AND ANALYSIS: A randomized, nonblinded,
      controlled trial will be carried out by recruiting a total of 66 eligible
      allergic rhinitis patients who fulfill the inclusion criteria from a university
      health center. The subjects will be randomly assigned into 2 groups: intervention
      group receiving facial candling treatment and control group (no treatment given).
      Samples of blood and nasal mucus will be collected right before and after
      intervention. Samples collected will be analyzed. The primary outcomes are the
      changes in the level of SP in both blood and mucus samples between both groups.
      The secondary outcomes include the levels of inflammatory mediators (ie, tumor
      necrosis factor alpha, interleukin (IL)-3, IL-5, IL-6, IL-10, and IL-13) and the 
      severity of allergic rhinitis symptoms as measured by a visual analogous scale
      and QoL using the Rhinitis Quality of Life Questionnaire (RQLQ). ETHICAL AND
      TRIAL REGISTRATION: The study protocols are approved from the Ethical and
      Research Committee of the Universiti Teknologi MARA (REC/113/15). The trial is
      registered under the Australia New Zealand Clinical Trial Registry
      (ACTRN12616000299404). The trial was registered on 03/07/2016 and the first
      patient was enrolled on 10/12/2016. CONCLUSION: Facial candling is one of the
      unique treatments using candles to reduce the severity of symptoms and
      inflammation. This is the first ever study conducted on facial candling that will
      give rise to new knowledge underlying the effects of facial candling on severity 
      of symptoms and inflammation relief mechanism mediated by substance P and
      inflammatory mediators.
FAU - Ismail, Nor Faizatul Fatikah
AU  - Ismail NFF
AD  - aFaculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam
      bCollaborative Drug Discovery Research (CDDR) Group, Pharmaceutical and Life
      Sciences CoRe, UiTM, Shah Alam, Selangor cEnvironmetal Health Department, Faculty
      of Health Sciences, UiTM, Bertam, Penang dVector-Borne Diseases Research Group
      (VERDI), Pharmaceutical and Life Sciences CoRe, UiTM, Shah Alam, Selangor
      eMedical Laboratory Department, Faculty of Health Sciences, UiTM, Puncak Alam,
      Johor fFaculty of Medicine, UiTM, Puncak Alam, Selangor gSchool of Pharmacy, KPJ 
      Healthcare University College, Nilai, Negeri Sembilan, Malaysia.
FAU - Neoh, Chin Fen
AU  - Neoh CF
FAU - Lim, Siong Meng
AU  - Lim SM
FAU - Abdullah, Amir Heberd
AU  - Abdullah AH
FAU - Mastuki, Mohd Fahmi
AU  - Mastuki MF
FAU - Ramasamy, Kalavathy
AU  - Ramasamy K
FAU - Zainuddin, Nazli
AU  - Zainuddin N
FAU - Saim, Lokman
AU  - Saim L
FAU - Ming, Long Chiau
AU  - Ming LC
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers)
RN  - 33507-63-0 (Substance P)
SB  - AIM
SB  - IM
MH  - Academic Medical Centers
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Humans
MH  - Malaysia
MH  - *Medicine, East Asian Traditional
MH  - Middle Aged
MH  - Mucus/metabolism
MH  - Nasal Cavity
MH  - Quality of Life
MH  - Rhinitis, Allergic/*immunology/*therapy
MH  - Severity of Illness Index
MH  - Substance P/*metabolism
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007511 [doi]
AID - 00005792-201707280-00026 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7511. doi: 10.1097/MD.0000000000007511.