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Promising significance of the association of miR-204-5p expression with clinicopathological features of hepatocellular carcinoma.

Abstract Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepatocellular carcinoma (HCC) as well as to predict the relevant signaling pathways. The miR-204-5p expression level was detected in HCC and in matched paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the real-time reverse transcription polymerized chain reaction (qRT-PCR). The association of miR-204-5p expression with clinicopathological features as well as the prognosis of HCC was examined. Public data portals including the Gene Expression Omnibus and The Cancer Genome Atlas were used to retrieve the HCC-related data in order to perform a comprehensive meta-analysis. Meanwhile, protein-protein interaction (PPI) and enrichment analyses were performed using predicted target genes. The relative expression of miR-204-5p was remarkably reduced in HCC than that in paraneoplastic hepatic tissues. In HCC, the miR-204-5p expression was downregulated in the metastasis, vasoinvasion, and advanced stage (III and IV) subgroups compared with their counterparts. Furthermore, the meta-analysis based on qRT-PCR data demonstrated that miR-204-5p was markedly downregulated in HCC with a standardized mean difference of -5.19 (Pā€Š<ā€Š.001). However, no significant association was observed between miR-204-5p and survival outcomes. The potential target genes of miR-204-5p were significantly enriched in several pathways which might be associated with HCC, such as "cell proliferation" from GO terms and "pathways in cancer" from the KEGG analysis. A PPI network of miR-204-5p potential target genes identified prospective core genes potentially involved in the regulation of HCC oncogenesis and progression. Our findings suggested that miR-204-5p might act as a tumor-suppressive gene in the tumorigenesis and progression of HCC via vital signaling pathways and that miR-204-5p could be regarded as a protective factor in HCC.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28746200
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - Promising significance of the association of miR-204-5p expression with
      clinicopathological features of hepatocellular carcinoma.
PG  - e7545
LID - 10.1097/MD.0000000000007545 [doi]
AB  - Decreased level of miR-204-5p has been documented in various malignancies.
      However, the expression and clinical significance of miR-204-5p in hepatocellular
      carcinoma has not been investigated. The aim of this study is to examine the
      relationship between miR-204-5p expression and clinicopathological features in
      hepatocellular carcinoma (HCC) as well as to predict the relevant signaling
      pathways. The miR-204-5p expression level was detected in HCC and in matched
      paraneoplastic liver from 95 formalin-fixed paraffin-embedded tissues by the
      real-time reverse transcription polymerized chain reaction (qRT-PCR). The
      association of miR-204-5p expression with clinicopathological features as well as
      the prognosis of HCC was examined. Public data portals including the Gene
      Expression Omnibus and The Cancer Genome Atlas were used to retrieve the
      HCC-related data in order to perform a comprehensive meta-analysis. Meanwhile,
      protein-protein interaction (PPI) and enrichment analyses were performed using
      predicted target genes. The relative expression of miR-204-5p was remarkably
      reduced in HCC than that in paraneoplastic hepatic tissues. In HCC, the
      miR-204-5p expression was downregulated in the metastasis, vasoinvasion, and
      advanced stage (III and IV) subgroups compared with their counterparts.
      Furthermore, the meta-analysis based on qRT-PCR data demonstrated that miR-204-5p
      was markedly downregulated in HCC with a standardized mean difference of -5.19 (P
      &lt; .001). However, no significant association was observed between miR-204-5p and 
      survival outcomes. The potential target genes of miR-204-5p were significantly
      enriched in several pathways which might be associated with HCC, such as "cell
      proliferation" from GO terms and "pathways in cancer" from the KEGG analysis. A
      PPI network of miR-204-5p potential target genes identified prospective core
      genes potentially involved in the regulation of HCC oncogenesis and progression. 
      Our findings suggested that miR-204-5p might act as a tumor-suppressive gene in
      the tumorigenesis and progression of HCC via vital signaling pathways and that
      miR-204-5p could be regarded as a protective factor in HCC.
FAU - Luo, Yi-Huan
AU  - Luo YH
AD  - aDepartment of Research bDepartment of Breast Surgery, Affiliated Cancer
      Hospital, Guangxi Medical University cDepartment of Pathology, First Affiliated
      Hospital of Guangxi Medical University dKey Laboratory for High-Incidence Tumor
      Prevention and Treatment, Ministry of Education, Guangxi Medical University,
      Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China.
FAU - Tang, Wei
AU  - Tang W
FAU - Zhang, Xin
AU  - Zhang X
FAU - Tan, Zhong
AU  - Tan Z
FAU - Guo, Wen-Liang
AU  - Guo WL
FAU - Zhao, Na
AU  - Zhao N
FAU - Pang, Si-Min
AU  - Pang SM
FAU - Dang, Yi-Wu
AU  - Dang YW
FAU - Rong, Min-Hua
AU  - Rong MH
FAU - Cao, Ji
AU  - Cao J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MIRN204 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Hepatocellular/*metabolism/pathology
MH  - Disease Progression
MH  - Humans
MH  - Liver/*metabolism/pathology
MH  - Liver Neoplasms/*metabolism/pathology
MH  - MicroRNAs/*metabolism
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Staging
MH  - Survival Analysis
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007545 [doi]
AID - 00005792-201707280-00031 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7545. doi: 10.1097/MD.0000000000007545.