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Nomograms predicting disease-specific regional recurrence and distant recurrence of papillary thyroid carcinoma following partial or total thyroidectomy.

Abstract The study aimed to establish effective nomograms for prediction of tumor regional recurrence and distant recurrence of papillary thyroid carcinoma (PTC) patients after partial or total thyroidectomy.These nomograms were based on a retrospective study on 1034 patients who underwent partial or total thyroidectomy for PTC. The predictive accuracy and discriminative ability of the nomograms were evaluated by the concordance index (C-index) and calibration curve. In addition, a validation cohort was included at the same institution.Multivariate analysis demonstrated that family history, maximal tumor diameter, capsular invasion, and lymph node staging were independent risk factors for regional recurrence-free survival; and family history, histological variants, capsular invasion, perineuronal invasion, and vascular invasion were independent risk factors for distant recurrence-free survival. They were selected into the 2 nomograms, respectively, and the C-index for regional recurrence-free survival and distant recurrence-free survival prediction were 0.72 and 0.83, respectively. In the validation cohort, the 2 nomograms displayed a C-index of 0.72 and 0.89, respectively.The nomograms developed in this study demonstrated their discrimination capability for predicting 3 and 5-year regional recurrence and distant recurrence after partial or total thyroidectomy, and can be used to identify high-risk patients.
PMID
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Authors

Mayor MeshTerms

Nomograms

Thyroidectomy

Keywords
Journal Title medicine
Publication Year Start




PMID- 28746205
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - Nomograms predicting disease-specific regional recurrence and distant recurrence 
      of papillary thyroid carcinoma following partial or total thyroidectomy.
PG  - e7575
LID - 10.1097/MD.0000000000007575 [doi]
AB  - The study aimed to establish effective nomograms for prediction of tumor regional
      recurrence and distant recurrence of papillary thyroid carcinoma (PTC) patients
      after partial or total thyroidectomy.These nomograms were based on a
      retrospective study on 1034 patients who underwent partial or total thyroidectomy
      for PTC. The predictive accuracy and discriminative ability of the nomograms were
      evaluated by the concordance index (C-index) and calibration curve. In addition, 
      a validation cohort was included at the same institution.Multivariate analysis
      demonstrated that family history, maximal tumor diameter, capsular invasion, and 
      lymph node staging were independent risk factors for regional recurrence-free
      survival; and family history, histological variants, capsular invasion,
      perineuronal invasion, and vascular invasion were independent risk factors for
      distant recurrence-free survival. They were selected into the 2 nomograms,
      respectively, and the C-index for regional recurrence-free survival and distant
      recurrence-free survival prediction were 0.72 and 0.83, respectively. In the
      validation cohort, the 2 nomograms displayed a C-index of 0.72 and 0.89,
      respectively.The nomograms developed in this study demonstrated their
      discrimination capability for predicting 3 and 5-year regional recurrence and
      distant recurrence after partial or total thyroidectomy, and can be used to
      identify high-risk patients.
FAU - Ge, Ming-Hua
AU  - Ge MH
AD  - aCollege of Medicine, Zhejiang University bDepartment of Head and Neck Surgery
      cMedical Record Department, Zhejiang Cancer Hospital dZhejiang Chinese Medical
      University eDepartment of General Surgery, Sir Run Run Shaw Hospital, College of 
      Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
FAU - Cao, Jun
AU  - Cao J
FAU - Wang, Jin-Yu
AU  - Wang JY
FAU - Huang, Yu-Qing
AU  - Huang YQ
FAU - Lan, Xia-Bin
AU  - Lan XB
FAU - Yu, Bin
AU  - Yu B
FAU - Wen, Qing-Liang
AU  - Wen QL
FAU - Cai, Xiu-Jun
AU  - Cai XJ
LA  - eng
PT  - Journal Article
PT  - Validation Studies
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - Thyroid cancer, papillary
SB  - AIM
SB  - IM
MH  - Adult
MH  - Calibration
MH  - Carcinoma/*diagnosis/pathology/*surgery
MH  - Disease-Free Survival
MH  - Family
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Recurrence, Local/*diagnosis/pathology
MH  - *Nomograms
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Thyroid Neoplasms/*diagnosis/pathology/*surgery
MH  - *Thyroidectomy
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007575 [doi]
AID - 00005792-201707280-00036 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7575. doi: 10.1097/MD.0000000000007575.