PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Association between relative liver enhancement on gadoxetic acid enhanced magnetic resonance images and histologic grade of hepatocellular carcinoma.

Abstract We evaluated the association between histologic grade of hepatocellular carcinoma (HCC) and degree of HCC enhancement on Gd-EOB-DTPA (Gadoxetic acid, Primovist)-enhanced magnetic resonance images (MRI) in HCC patients.A total of 121 patients who underwent curative surgical resection for HCC at our institution between January 2012 and March 2015 were retrospectively analyzed. Gadoxetic acid enhanced MRI was performed in all patients before surgery. Signal intensities of HCC and peri-HCC areas were measured using regions of interest. Relative intensity ratios of HCC lesions versus the surrounding non-HCC areas on unenhanced images (precontrast ratio) and on hepatobiliary phase images (postcontrast ratio) were calculated. Relative liver enhancement (RLE) ratios (post-contrast ratio/pre-contrast ratio) were also calculated. The Edmondson-Steiner (E-S) grading system was used to histologically grade HCC.E-S grades I, II, III, and IV were observed in 2 (1.7%), 14 (11.6%), 54 (44.6%), and 51 (42.1%) of the patients, respectively. For E-S grades I/II (n = 16), III (n = 54), and IV (n = 51), mean RLE (%) were 85.5, 84.9, and 71.2, respectively (P = .01), and for E-S grades I-III (n = 70) and IV (n = 51), mean RLE (%) were 85.1 and 71.2, respectively (P < .01). Barcelona Clinic Liver Cancer (BCLC) stage A (vs 0) (odds ratio 4.38, P = .03) and mean RLE (odds ratio 0.05, P < .01) were found to predict E-S grade IV.E-S grade IV was associated with a low level mean RLE in the gadoxetic acid enhanced MR images of HCC patients.
PMID
Related Publications

Histological grade of hepatocellular carcinoma correlates with arterial enhancement on gadoxetic acid-enhanced and diffusion-weighted MR images.

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging predicts the histological grade of hepatocellular carcinoma only in patients with Child-Pugh class A cirrhosis.

Characterization of small (≤3 cm) hepatic lesions with atypical enhancement feature and hypointensity in hepatobiliary phase of gadoxetic acid-enhanced MRI in cirrhosis: A STARD-compliant article.

Diagnostic performance of gadoxetic acid-enhanced liver MR imaging in the detection of HCCs and allocation of transplant recipients on the basis of the Milan criteria and UNOS guidelines: correlation with histopathologic findings.

Prediction of postoperative liver failure using gadoxetic acid-enhanced magnetic resonance imaging in patients with hepatocellular carcinoma.

Authors

Mayor MeshTerms

Contrast Media

Gadolinium DTPA

Magnetic Resonance Imaging

Keywords
Journal Title medicine
Publication Year Start




PMID- 28746206
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - Association between relative liver enhancement on gadoxetic acid enhanced
      magnetic resonance images and histologic grade of hepatocellular carcinoma.
PG  - e7580
LID - 10.1097/MD.0000000000007580 [doi]
AB  - We evaluated the association between histologic grade of hepatocellular carcinoma
      (HCC) and degree of HCC enhancement on Gd-EOB-DTPA (Gadoxetic acid,
      Primovist)-enhanced magnetic resonance images (MRI) in HCC patients.A total of
      121 patients who underwent curative surgical resection for HCC at our institution
      between January 2012 and March 2015 were retrospectively analyzed. Gadoxetic acid
      enhanced MRI was performed in all patients before surgery. Signal intensities of 
      HCC and peri-HCC areas were measured using regions of interest. Relative
      intensity ratios of HCC lesions versus the surrounding non-HCC areas on
      unenhanced images (precontrast ratio) and on hepatobiliary phase images
      (postcontrast ratio) were calculated. Relative liver enhancement (RLE) ratios
      (post-contrast ratio/pre-contrast ratio) were also calculated. The
      Edmondson-Steiner (E-S) grading system was used to histologically grade HCC.E-S
      grades I, II, III, and IV were observed in 2 (1.7%), 14 (11.6%), 54 (44.6%), and 
      51 (42.1%) of the patients, respectively. For E-S grades I/II (n = 16), III (n = 
      54), and IV (n = 51), mean RLE (%) were 85.5, 84.9, and 71.2, respectively (P =
      .01), and for E-S grades I-III (n = 70) and IV (n = 51), mean RLE (%) were 85.1
      and 71.2, respectively (P &lt; .01). Barcelona Clinic Liver Cancer (BCLC) stage A
      (vs 0) (odds ratio 4.38, P = .03) and mean RLE (odds ratio 0.05, P &lt; .01) were
      found to predict E-S grade IV.E-S grade IV was associated with a low level mean
      RLE in the gadoxetic acid enhanced MR images of HCC patients.
FAU - Jin, Young-Joo
AU  - Jin YJ
AD  - aDepartment of Internal Medicine bDepartment of Radiology cDepartment of Surgery 
      dDepartment of Pathology, Inha University Hospital, Inha University School of
      Medicine, Incheon, South Korea.
FAU - Cho, Soon Gu
AU  - Cho SG
FAU - Lee, Kun Young
AU  - Lee KY
FAU - Kim, Joon Mee
AU  - Kim JM
FAU - Lee, Jin Woo
AU  - Lee JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Contrast Media)
RN  - 0 (gadolinium ethoxybenzyl DTPA)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/*diagnostic imaging/pathology/surgery
MH  - *Contrast Media
MH  - Female
MH  - Follow-Up Studies
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Liver/*diagnostic imaging/pathology/surgery
MH  - Liver Neoplasms/*diagnostic imaging/pathology/surgery
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Preoperative Care
MH  - Retrospective Studies
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007580 [doi]
AID - 00005792-201707280-00037 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7580. doi: 10.1097/MD.0000000000007580.