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The impact of host's genetic susceptibility on Helicobacter pylori infection in children.

Abstract The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. Children were assessed clinically, endoscopically, histopathologically, and genetically.In our study, we found that the presence of the CT and CT+TT genotypes of IL-6 190C/T (P < .002 and P = .04), allele G of IL-6 572 G/C polymorphism (P = .01), genotypes GA and AA of TNF-α 308 G/A polymorphism (P = .04, P = .01), and genotype II of ACE I/D polymorphism (P = .02) were associated with H. pylori infection, while the CC genotype of IL-6 174G/C polymorphism was scarcely encountered in children with H. pylori infection [P = .02, odds ratio (OR) = 0.06; 95% confidence interval (95% CI): 0.003-0.128]. Taking under consideration the 4 variant genotypes (IL-6 572G/C, IL-6 190C/T, TNF-α 308G/A, and ACE I/D), we noticed a 2 times higher incidence of H. pylori infection (OR = 6.34; 95% CI: 2.15-25.8).We may consider that the IL-6 190C/T, IL-6 174G/C, IL-6 572G/C, TNF-α 308G/A, and ACE I/D gene polymorphisms may increase the children's susceptibility for acquiring H. pylori infection; therefore, they may contribute to the pathogenesis of H. pylori gastritis.
PMID
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Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Helicobacter pylori

Keywords
Journal Title medicine
Publication Year Start




PMID- 28746216
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - The impact of host's genetic susceptibility on Helicobacter pylori infection in
      children.
PG  - e7612
LID - 10.1097/MD.0000000000007612 [doi]
AB  - The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, 
      IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-alpha) 308G/A, and
      angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori
      (H. pylori) infection in children.A cross-sectional study was performed on 126
      children (57 children with H. pylori infection and 69 children without H. pylori 
      infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary
      Hospital from Romania. Children were assessed clinically, endoscopically,
      histopathologically, and genetically.In our study, we found that the presence of 
      the CT and CT+TT genotypes of IL-6 190C/T (P &lt; .002 and P = .04), allele G of
      IL-6 572 G/C polymorphism (P = .01), genotypes GA and AA of TNF-alpha 308 G/A
      polymorphism (P = .04, P = .01), and genotype II of ACE I/D polymorphism (P =
      .02) were associated with H. pylori infection, while the CC genotype of IL-6
      174G/C polymorphism was scarcely encountered in children with H. pylori infection
      [P = .02, odds ratio (OR) = 0.06; 95% confidence interval (95% CI): 0.003-0.128].
      Taking under consideration the 4 variant genotypes (IL-6 572G/C, IL-6 190C/T,
      TNF-alpha 308G/A, and ACE I/D), we noticed a 2 times higher incidence of H.
      pylori infection (OR = 6.34; 95% CI: 2.15-25.8).We may consider that the IL-6
      190C/T, IL-6 174G/C, IL-6 572G/C, TNF-alpha 308G/A, and ACE I/D gene
      polymorphisms may increase the children's susceptibility for acquiring H. pylori 
      infection; therefore, they may contribute to the pathogenesis of H. pylori
      gastritis.
FAU - Marginean, Maria Oana
AU  - Marginean MO
AD  - aDepartment of Pediatrics, University of Medicine and Pharmacy Tirgu Mures
      bDepartment of Epidemiology, University of Medicine and Pharmacy Tirgu Mures
      cGenetics Laboratory, Center for Advanced Medical and Pharmaceutical Research,
      University of Medicine and Pharmacy Tirgu Mures, Romania.
FAU - Marginean, Cristina Oana
AU  - Marginean CO
FAU - Melit, Lorena Elena
AU  - Melit LE
FAU - Voidazan, Septimiu
AU  - Voidazan S
FAU - Moldovan, Valeriu
AU  - Moldovan V
FAU - Banescu, Claudia
AU  - Banescu C
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - AIM
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Helicobacter Infections/epidemiology/*genetics/immunology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Incidence
MH  - Interleukin-6/*genetics
MH  - Logistic Models
MH  - Male
MH  - Multivariate Analysis
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Prospective Studies
MH  - Romania
MH  - Tertiary Care Centers
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007612 [doi]
AID - 00005792-201707280-00047 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7612. doi: 10.1097/MD.0000000000007612.