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The prognostic value of preoperative inflammation-based prognostic scores and nutritional status for overall survival in resected patients with nonmetastatic Siewert type II/III adenocarcinoma of esophagogastric junction.

Abstract Immune and nutritional status of patients have been reported to predict postoperative complications, recurrence, and prognosis of patients with cancer. Therefore, this retrospective study aimed to explore the prognostic value of preoperative inflammation-based prognostic scores [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] and nutritional status [prognostic nutritional index (PNI), body mass index (BMI), hemoglobin, albumin, and prealbumin] for overall survival (OS) in adenocarcinoma of esophagogastric junction (AEG) patients.
PMID
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Authors

Mayor MeshTerms

Nutritional Status

Keywords
Journal Title medicine
Publication Year Start




PMID- 28746229
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - The prognostic value of preoperative inflammation-based prognostic scores and
      nutritional status for overall survival in resected patients with nonmetastatic
      Siewert type II/III adenocarcinoma of esophagogastric junction.
PG  - e7647
LID - 10.1097/MD.0000000000007647 [doi]
AB  - BACKGROUND: Immune and nutritional status of patients have been reported to
      predict postoperative complications, recurrence, and prognosis of patients with
      cancer. Therefore, this retrospective study aimed to explore the prognostic value
      of preoperative inflammation-based prognostic scores [neutrophil-lymphocyte ratio
      (NLR), platelet-lymphocyte ratio (PLR)] and nutritional status [prognostic
      nutritional index (PNI), body mass index (BMI), hemoglobin, albumin, and
      prealbumin] for overall survival (OS) in adenocarcinoma of esophagogastric
      junction (AEG) patients. METHODS: A total of 355 patients diagnosed with Siewert 
      type II/III AEG and underwent surgery between October 2010 and December 2011 were
      followed up until October 2016. Receiver operating characteristic (ROC) curve
      analysis was used to determine the cutoff values of NLR, PLR, and PNI.
      Kaplan-Meier curves and Cox regression analyses were used to calculate the OS
      characteristics. RESULTS: The ideal cutoff values for predicting OS were 3.5 for 
      NLR, 171 for PLR, and 51.3 for PNI according to the ROC curve. The patients with 
      hemoglobin <120 g/L (P = .001), prealbumin <180 mg/L (P = .000), PNI <51.3 (P =
      .010), NLR >3.5 (P = .000), PLR >171 (P = .006), and low BMI group (P = .000) had
      shorter OS. And multivariate survival analysis using the Cox proportional hazards
      model showed that the tumor-node-metastasis stage, BMI, NLR, and prealbumin
      levels were independent risk factors for the OS. CONCLUSION: Our study
      demonstrated that preoperative prealbumin, BMI, and NLR were independent
      prognostic factors of AEG patients.
FAU - Zhang, Lixiang
AU  - Zhang L
AD  - aDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Anhui
      Medical University bAnhui Medical University, Hefei, Anhui, China.
FAU - Su, Yezhou
AU  - Su Y
FAU - Chen, Zhangming
AU  - Chen Z
FAU - Wei, Zhijian
AU  - Wei Z
FAU - Han, Wenxiu
AU  - Han W
FAU - Xu, Aman
AU  - Xu A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Prealbumin)
RN  - Adenocarcinoma Of Esophagus
SB  - AIM
SB  - IM
MH  - Adenocarcinoma/*metabolism/*surgery
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - Biomarkers, Tumor/blood/immunology
MH  - Body Mass Index
MH  - Esophageal Neoplasms/*metabolism/*surgery
MH  - Esophagogastric Junction/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Nutrition Assessment
MH  - *Nutritional Status
MH  - Prealbumin/metabolism
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007647 [doi]
AID - 00005792-201707280-00060 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7647. doi: 10.1097/MD.0000000000007647.