PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

A comparative study to evaluate the efficacy of EGF, FGF-2, and 0.3% (w/v) ofloxacin drops on eardrum regeneration.

Abstract Traumatic tympanic membrane perforations (TMPs) tend to spontaneous healing, however, large TMPs usually fail to healing. Clinical and experimental studies had demonstrated that growth factors accelerated the healing of large TMPs. The aim of this study was to compare the effects of growth factors and 0.3% (w/v) ofloxacin drops n the healing of human large TMPs.
PMID
Related Publications

The effect of ofloxacin otic drops on the regeneration of human traumatic tympanic membrane perforations.

A retrospective study of EGF and ofloxacin drops in the healing of human large traumatic eardrum perforation.

Healing large traumatic eardrum perforations in humans using fibroblast growth factor applied directly or via gelfoam.

Risk factors affecting human traumatic tympanic membrane perforation regeneration therapy using fibroblast growth factor-2.

Comparative study on the effects of EGF and bFGF on the healing of human large traumatic perforations of the tympanic membrane.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28746231
OWN - NLM
STAT- MEDLINE
DA  - 20170726
DCOM- 20170807
LR  - 20170807
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 30
DP  - 2017 Jul
TI  - A comparative study to evaluate the efficacy of EGF, FGF-2, and 0.3% (w/v)
      ofloxacin drops on eardrum regeneration.
PG  - e7654
LID - 10.1097/MD.0000000000007654 [doi]
AB  - BACKGROUND: Traumatic tympanic membrane perforations (TMPs) tend to spontaneous
      healing, however, large TMPs usually fail to healing. Clinical and experimental
      studies had demonstrated that growth factors accelerated the healing of large
      TMPs. The aim of this study was to compare the effects of growth factors and 0.3%
      (w/v) ofloxacin drops n the healing of human large TMPs. METHODS: A total of 184 
      human large traumatic TMPs were randomly assigned to receive epidermal growth
      factor (EGF) treatment, fibroblast growth factor-2 (FGF-2) treatment, 0.3% (w/v) 
      ofloxacin drops treatment, and conservative observation (only). RESULTS: A total 
      of 180 patients were analyzed in this study at the 6-month follow-up. The closure
      rates of the perforations in the EGF, FGF-2, 0.3% (w/v) ofloxacin drops, and
      conservative observation groups were 91.11%, 93.18%, 95.65%, and 82.22%,
      respectively, the closure rates did not significantly differ among the groups (P 
      = .165). Similarly, pairwise comparisons did not reveal any significant
      between-group differences (P > .0083). However, the difference of the mean
      closure time was significant among the 4 groups (P < .001), pairwise comparisons 
      showed that closure time was significantly longer in the observational group than
      in the other 3 groups (P < .001). Nevertheless, no significant difference in mean
      closure time was evident between any 2 treated groups (P > .0083). The mean
      hearing gain after 6 months was 11.49 +/- 5.88 dB for the EGF group, 10.89 +/-
      5.16 dB for the FGF-2 group, 10.54 +/- 5.56 dB for the ofloxacin group, and 9.29 
      +/- 5.36 dB for the observation group. Differences in hearing improvement rates
      among the 4 groups were not statistically significant (P = .283). CONCLUSION:
      Epidermal growth factor, FGF-2, and 0.3% (w/v) ofloxacin drops accelerated the
      closure of large TMPs compared with conservative treatment. Surprisingly, neither
      the closure rate nor closure time differed significantly among the 3 treated
      groups. Further experimental studies to demonstrate whether 0.3% (w/v) ofloxacin 
      per se accelerates the healing of TMPs will be interesting in the future.
FAU - Lou, Zhengcai
AU  - Lou Z
AD  - aDepartment of Otorhinolaryngology, The Affiliated Yiwu Hospital of Wenzhou
      Medical University, Yiwu, Zhejiang bDepartment of Clinical Medicine, Xinxiang
      Medical University, Xinxiang, Henan, China.
FAU - Lou, Zihan
AU  - Lou Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - A4P49JAZ9H (Ofloxacin)
SB  - AIM
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Conservative Treatment
MH  - Epidermal Growth Factor/*administration & dosage
MH  - Female
MH  - Fibroblast Growth Factor 2/*administration & dosage
MH  - Follow-Up Studies
MH  - Hearing Tests
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*administration & dosage
MH  - Male
MH  - Ofloxacin/*administration & dosage
MH  - Recovery of Function/drug effects
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tympanic Membrane/drug effects/pathology/physiopathology
MH  - Tympanic Membrane Perforation/*drug therapy/pathology/physiopathology
MH  - Wound Healing/*drug effects
EDAT- 2017/07/27 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/07/27 06:00
AID - 10.1097/MD.0000000000007654 [doi]
AID - 00005792-201707280-00062 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Jul;96(30):e7654. doi: 10.1097/MD.0000000000007654.