PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28748017
OWN - NLM
STAT- MEDLINE
DA  - 20170727
DCOM- 20170804
LR  - 20170804
IS  - 1937-8688 (Electronic)
VI  - 27
DP  - 2017
TI  - [Factors associated with immunovirologic dissociation in HIV-1-infected patients 
      under highly active antiretroviral therapy in the Ambulatory Treatment Center
      (ATC) in Dakar].
PG  - 16
LID - 10.11604/pamj.2017.27.16.9811 [doi]
AB  - INTRODUCTION: The objective of this work is to evaluate the different factors
      associated with immunovirologic dissociation despite highly active and effective 
      antiretroviral treatment. METHODS: We conducted a retrospective, cohort,
      descriptive and analytical study of the medical records of HIV-1 infected
      patients having received at least 12 months of antiretroviral therapy, followed
      in the ATC cohort from 2001 to 2011 and with undetectable viral load in the last 
      6 months. RESULTS: During this 10-year study period, the prevalence of IVD was
      19.3%. Female sex was predominant, with a sex ratio of 1.9. Immunovirologic
      dissociation was more frequent in male patients (29.7% vs 14.1%) with a
      statistically significant difference (p = 0,00006). The average age was 44 years 
      +/- 10 years. A history of tuberculosis was found in about a third of the cases
      (31.4%). Immunovirologic dissociation was significantly more frequent in patients
      with a history of tuberculosis (p = 0.00005). Most patients (68%) had AIDS at WHO
      clinical stages 3 or 4. Patients with immunovirologic dissociation were more
      often in WHO clinical stages 3 and 4 (p = 0.0001). More than half of the cases
      (56.2%) were found to be malnourished and immunovirologic dissociation was
      prevalent in malnourished patients (p=0.005). The mean CD4+ T lymphocytes counts 
      was 86.7+/- 83 cells / mm3. Immunovirologic dissociation was more frequent in
      patients with initial low CD4+ T lymphocyte counts and with a statistically
      significant difference (p = 0.00000). By multivariate analysis, only age greater 
      than or equal to 43 years, CD4 initial counts < 100 c/mm3 and male sex were
      significantly associated with this immunovirologic dissociation. CONCLUSION: Our 
      study assessed the main factors associated with immunovirologic dissociation.
      Other studies of this nature would also merit consideration in order to highlight
      the impact of this partial immune response on the emergence of opportunistic
      infections or the implementation of a specific tritherapy for the sole purpose of
      producing fully successful immune restoration.
FAU - Ka, Daye
AU  - Ka D
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Manga, Noel Magloire
AU  - Manga NM
AD  - UFR Sante - Universite de Ziguinchor Senegal.
FAU - Ngom-Gueye, Ndeye Fatou
AU  - Ngom-Gueye NF
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Ndiaga, Diop
AU  - Ndiaga D
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Diop, Moustapha
AU  - Diop M
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Cisse-Diallo, Viviane Marie Pierre
AU  - Cisse-Diallo VMP
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Diallo-Mbaye, Khardiata
AU  - Diallo-Mbaye K
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Lakhe, Ndeye Aissatou
AU  - Lakhe NA
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Fortes-Deguenonvo, Louise
AU  - Fortes-Deguenonvo L
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Ndour, Cheikh Tidiane
AU  - Ndour CT
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
FAU - Diop-Nyafouna, Sylvie Audrey
AU  - Diop-Nyafouna SA
AD  - UFR Sante, Universite de Thies Senegal.
FAU - Seydi, Moussa
AU  - Seydi M
AD  - Service des Maladies Infectieuses et Tropicales de Fann, Universite Cheikh Anta
      Diop de Dakar, Senegal.
LA  - fre
PT  - Journal Article
TT  - Facteurs associes a la dissociation immunovirologique chez les patients infectes 
      par le VIH-1 sous traitement antiretroviral hautement actif au Centre de
      Traitement Ambulatoire (CTA) de Dakar.
DEP - 20170508
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Anti-HIV Agents/*administration & dosage
MH  - Antiretroviral Therapy, Highly Active/methods
MH  - CD4 Lymphocyte Count
MH  - Cohort Studies
MH  - Female
MH  - HIV Infections/*drug therapy/immunology/virology
MH  - HIV-1/*isolation & purification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Senegal
MH  - Sex Factors
MH  - Treatment Outcome
MH  - Tuberculosis/*epidemiology
MH  - Young Adult
PMC - PMC5511707
OTO - NOTNLM
OT  - Dakar
OT  - Dissociation
OT  - HIV
OT  - immunovirologic
EDAT- 2017/07/28 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/28 06:00
PHST- 2016/05/08 [received]
PHST- 2017/03/29 [accepted]
AID - 10.11604/pamj.2017.27.16.9811 [doi]
AID - PAMJ-27-16 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 May 8;27:16. doi: 10.11604/pamj.2017.27.16.9811. eCollection 
      2017.