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Retinal Vessel Geometry and the Incidence and Progression of Diabetic Retinopathy.

Abstract To analyze the associations between retinal vessel geometry and the 1-year incidence and progression of diabetic retinopathy (DR) in a Chinese population.
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28750414
OWN - NLM
STAT- MEDLINE
DA  - 20170727
DCOM- 20170804
LR  - 20170804
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 6
DP  - 2017 May 01
TI  - Retinal Vessel Geometry and the Incidence and Progression of Diabetic
      Retinopathy.
PG  - BIO200-BIO205
LID - 10.1167/iovs.17-21699 [doi]
AB  - Purpose: To analyze the associations between retinal vessel geometry and the
      1-year incidence and progression of diabetic retinopathy (DR) in a Chinese
      population. Methods: This was a prospective cohort study of adult subjects with
      diabetes mellitus. Retinal vascular geometry was quantified from fundus
      photographs using a semiautomated computer-assisted program. Diabetic retinopathy
      was graded from retinal photographs at baseline and 1 year. Incident DR and
      2-step change in DR were analyzed. Results: In total, 249 subjects were included.
      Their mean age was 59.9 +/- 8.9 years, 74% were male, and the mean glycated
      hemoglobin A1c (HbA1C) and duration of diabetes were 7.7 +/- 1.4% and 14.3 +/-
      10.6 years, respectively. The distribution of DR severity at baseline was no DR
      in 35.7%, minimal nonproliferative diabetic retinopathy (NPDR) in 15.3%, mild
      NPDR in 14.6%, moderate NPDR in 23.1%, severe NPDR in 5.1%, and proliferative DR 
      in 6.1% of eyes. In multivariate analyses adjusting for age, duration of
      diabetes, sex, smoking status, HbA1c, hypertension, and hyperlipidemia, subjects 
      with higher venular fractal dimensions were more likely to have incident DR (odds
      ratio [OR] 0.38, [95% confidence interval (CI), 0.15-0.96], P = 0.032, per SD
      decrease). Lower venular tortuosity was associated with a lower likelihood of DR 
      progression (OR 0.76, [95% CI, 0.59-0.97], P = 0.005, per SD decrease). Lower
      arteriolar tortuosity was associated with a greater likelihood of DR regression
      (OR 1.95, [95% CI 1.07-3.56], P = 0.037, per SD decrease). Conclusions: Novel
      measures of retinal vascular geometry are associated with the incidence and
      progression of DR at 1 year. These geometric measures are likely to represent
      early dysfunction in the retinal microvasculature.
FAU - Lim, Laurence S
AU  - Lim LS
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical
      School, Singapore 2Department of Ophthalmology, Yong Loo Lin School of Medicine, 
      National University of Singapore, Singapore.
FAU - Chee, Miao Li
AU  - Chee ML
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical
      School, Singapore.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical
      School, Singapore 3Department of Ophthalmology and Visual Sciences, The Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Wong, Tien Yin
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Centre, Duke-NUS Medical
      School, Singapore 2Department of Ophthalmology, Yong Loo Lin School of Medicine, 
      National University of Singapore, Singapore.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Hemoglobin A, Glycosylated)
RN  - 0 (Lipids)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Aged
MH  - Asian Continental Ancestry Group/ethnology
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 1/complications
MH  - Diabetes Mellitus, Type 2/complications
MH  - Diabetic Retinopathy/*diagnosis/*epidemiology
MH  - Disease Progression
MH  - Female
MH  - Hemoglobin A, Glycosylated/metabolism
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Incidence
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Photography
MH  - Prospective Studies
MH  - Retinal Vessels/*pathology
MH  - Risk Factors
EDAT- 2017/07/28 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/07/28 06:00
AID - 2645714 [pii]
AID - 10.1167/iovs.17-21699 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO200-BIO205. doi:
      10.1167/iovs.17-21699.