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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Abstract Elucidation of the mutational landscape of human cancer has progressed rapidly and been accompanied by the development of therapeutics targeting mutant oncogenes. However, a comprehensive mapping of cancer dependencies has lagged behind and the discovery of therapeutic targets for counteracting tumor suppressor gene loss is needed. To identify vulnerabilities relevant to specific cancer subtypes, we conducted a large-scale RNAi screen in which viability effects of mRNA knockdown were assessed for 7,837 genes using an average of 20 shRNAs per gene in 398 cancer cell lines. We describe findings of this screen, outlining the classes of cancer dependency genes and their relationships to genetic, expression, and lineage features. In addition, we describe robust gene-interaction networks recapitulating both protein complexes and functional cooperation among complexes and pathways. This dataset along with a web portal is provided to the community to assist in the discovery and translation of new therapeutic approaches for cancer.
PMID
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Authors

Mayor MeshTerms

RNA Interference

Keywords

CCLE

DRIVE

RNA interference

cancer dependency

functional genomics

synthetic lethality

Journal Title cell
Publication Year Start




PMID- 28753431
OWN - NLM
STAT- MEDLINE
DA  - 20170728
DCOM- 20170808
LR  - 20170808
IS  - 1097-4172 (Electronic)
IS  - 0092-8674 (Linking)
VI  - 170
IP  - 3
DP  - 2017 Jul 27
TI  - Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal
      Relationships Uncovered by Large-Scale, Deep RNAi Screening.
PG  - 577-592.e10
LID - S0092-8674(17)30812-7 [pii]
LID - 10.1016/j.cell.2017.07.005 [doi]
AB  - Elucidation of the mutational landscape of human cancer has progressed rapidly
      and been accompanied by the development of therapeutics targeting mutant
      oncogenes. However, a comprehensive mapping of cancer dependencies has lagged
      behind and the discovery of therapeutic targets for counteracting tumor
      suppressor gene loss is needed. To identify vulnerabilities relevant to specific 
      cancer subtypes, we conducted a large-scale RNAi screen in which viability
      effects of mRNA knockdown were assessed for 7,837 genes using an average of 20
      shRNAs per gene in 398 cancer cell lines. We describe findings of this screen,
      outlining the classes of cancer dependency genes and their relationships to
      genetic, expression, and lineage features. In addition, we describe robust
      gene-interaction networks recapitulating both protein complexes and functional
      cooperation among complexes and pathways. This dataset along with a web portal is
      provided to the community to assist in the discovery and translation of new
      therapeutic approaches for cancer.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - McDonald, E Robert 3rd
AU  - McDonald ER 3rd
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA. Electronic 
      address: [email protected]
FAU - de Weck, Antoine
AU  - de Weck A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Schlabach, Michael R
AU  - Schlabach MR
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Billy, Eric
AU  - Billy E
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Mavrakis, Konstantinos J
AU  - Mavrakis KJ
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Hoffman, Gregory R
AU  - Hoffman GR
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Belur, Dhiren
AU  - Belur D
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Castelletti, Deborah
AU  - Castelletti D
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Frias, Elizabeth
AU  - Frias E
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Gampa, Kalyani
AU  - Gampa K
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Golji, Javad
AU  - Golji J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Kao, Iris
AU  - Kao I
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Li, Li
AU  - Li L
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Megel, Philippe
AU  - Megel P
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Perkins, Thomas A
AU  - Perkins TA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Ramadan, Nadire
AU  - Ramadan N
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Ruddy, David A
AU  - Ruddy DA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Silver, Serena J
AU  - Silver SJ
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Sovath, Sosathya
AU  - Sovath S
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Stump, Mark
AU  - Stump M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Weber, Odile
AU  - Weber O
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Widmer, Roland
AU  - Widmer R
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Yu, Jianjun
AU  - Yu J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Yu, Kristine
AU  - Yu K
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Yue, Yingzi
AU  - Yue Y
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Abramowski, Dorothee
AU  - Abramowski D
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Ackley, Elizabeth
AU  - Ackley E
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Barrett, Rosemary
AU  - Barrett R
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Berger, Joel
AU  - Berger J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Bernard, Julie L
AU  - Bernard JL
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Billig, Rebecca
AU  - Billig R
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Brachmann, Saskia M
AU  - Brachmann SM
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Buxton, Frank
AU  - Buxton F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Caothien, Roger
AU  - Caothien R
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Caushi, Justina X
AU  - Caushi JX
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Chung, Franklin S
AU  - Chung FS
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Cortes-Cros, Marta
AU  - Cortes-Cros M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - deBeaumont, Rosalie S
AU  - deBeaumont RS
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Delaunay, Clara
AU  - Delaunay C
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Desplat, Aurore
AU  - Desplat A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Duong, William
AU  - Duong W
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Dwoske, Donald A
AU  - Dwoske DA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Eldridge, Richard S
AU  - Eldridge RS
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Farsidjani, Ali
AU  - Farsidjani A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Feng, Fei
AU  - Feng F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Feng, JiaJia
AU  - Feng J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Flemming, Daisy
AU  - Flemming D
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Forrester, William
AU  - Forrester W
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Galli, Giorgio G
AU  - Galli GG
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Gao, Zhenhai
AU  - Gao Z
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Gauter, Francois
AU  - Gauter F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Gibaja, Veronica
AU  - Gibaja V
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Haas, Kristy
AU  - Haas K
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Hattenberger, Marc
AU  - Hattenberger M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Hood, Tami
AU  - Hood T
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Hurov, Kristen E
AU  - Hurov KE
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Jagani, Zainab
AU  - Jagani Z
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Jenal, Mathias
AU  - Jenal M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Johnson, Jennifer A
AU  - Johnson JA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Jones, Michael D
AU  - Jones MD
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Kapoor, Avnish
AU  - Kapoor A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Korn, Joshua
AU  - Korn J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Liu, Jilin
AU  - Liu J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Liu, Qiumei
AU  - Liu Q
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Liu, Shumei
AU  - Liu S
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Liu, Yue
AU  - Liu Y
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Loo, Alice T
AU  - Loo AT
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Macchi, Kaitlin J
AU  - Macchi KJ
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Martin, Typhaine
AU  - Martin T
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - McAllister, Gregory
AU  - McAllister G
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Meyer, Amandine
AU  - Meyer A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Molle, Sandra
AU  - Molle S
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Pagliarini, Raymond A
AU  - Pagliarini RA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Phadke, Tanushree
AU  - Phadke T
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Repko, Brian
AU  - Repko B
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Schouwey, Tanja
AU  - Schouwey T
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Shanahan, Frances
AU  - Shanahan F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Shen, Qiong
AU  - Shen Q
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Stamm, Christelle
AU  - Stamm C
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Stephan, Christine
AU  - Stephan C
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Stucke, Volker M
AU  - Stucke VM
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Tiedt, Ralph
AU  - Tiedt R
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Varadarajan, Malini
AU  - Varadarajan M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Venkatesan, Kavitha
AU  - Venkatesan K
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Vitari, Alberto C
AU  - Vitari AC
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Wallroth, Marco
AU  - Wallroth M
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Weiler, Jan
AU  - Weiler J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Mickanin, Craig
AU  - Mickanin C
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Myer, Vic E
AU  - Myer VE
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Porter, Jeffery A
AU  - Porter JA
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Lai, Albert
AU  - Lai A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Bitter, Hans
AU  - Bitter H
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Lees, Emma
AU  - Lees E
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Keen, Nicholas
AU  - Keen N
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Kauffmann, Audrey
AU  - Kauffmann A
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Stegmeier, Frank
AU  - Stegmeier F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Hofmann, Francesco
AU  - Hofmann F
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
FAU - Schmelzle, Tobias
AU  - Schmelzle T
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA. Electronic 
      address: [email protected]
FAU - Sellers, William R
AU  - Sellers WR
AD  - Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002,
      Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Multiprotein Complexes)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Cell Line, Tumor
MH  - Gene Library
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Multiprotein Complexes/metabolism
MH  - Neoplasms/*genetics/metabolism/*pathology
MH  - Oncogenes
MH  - *RNA Interference
MH  - RNA, Small Interfering
MH  - Signal Transduction
MH  - Transcription Factors/metabolism
OTO - NOTNLM
OT  - CCLE
OT  - DRIVE
OT  - RNA interference
OT  - cancer dependency
OT  - functional genomics
OT  - synthetic lethality
EDAT- 2017/07/29 06:00
MHDA- 2017/08/09 06:00
CRDT- 2017/07/29 06:00
PHST- 2017/03/24 [received]
PHST- 2017/06/02 [revised]
PHST- 2017/07/06 [accepted]
AID - S0092-8674(17)30812-7 [pii]
AID - 10.1016/j.cell.2017.07.005 [doi]
PST - ppublish
SO  - Cell. 2017 Jul 27;170(3):577-592.e10. doi: 10.1016/j.cell.2017.07.005.