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HIV-Associated Complications: A Systems-Based Approach.

Abstract Persons with human immunodeficiency virus (HIV) infection often develop complications related directly to the infection, as well as to treatment. Aging, lifestyle factors, and comorbidities increase the risk of developing chronic conditions such as diabetes mellitus and chronic kidney disease. HIV-associated neurologic complications encompass a wide spectrum of pathophysiology and symptomatology. Cardiovascular and pulmonary conditions are common among persons with HIV infection. Although some specific antiretroviral medications have been linked to disease development, traditional risk factors (e.g., smoking) have major roles. Prevention and management of viral hepatitis coinfection are important to reduce morbidity and mortality, and new anti-hepatitis C agents produce high rates of sustained virologic response. Antiretroviral-associated metabolic complications include dyslipidemia, hyperglycemia, and loss of bone mineral density. Newer options generally pose less risk of significant systemic toxicity and are better tolerated. Family physicians who care for patients with HIV infection have a key role in identifying and managing many of these chronic complications.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title american family physician
Publication Year Start




PMID- 28762691
OWN - NLM
STAT- In-Process
DA  - 20170801
LR  - 20170801
IS  - 1532-0650 (Electronic)
IS  - 0002-838X (Linking)
VI  - 96
IP  - 3
DP  - 2017 Aug 01
TI  - HIV-Associated Complications: A Systems-Based Approach.
PG  - 161-169
AB  - Persons with human immunodeficiency virus (HIV) infection often develop
      complications related directly to the infection, as well as to treatment. Aging, 
      lifestyle factors, and comorbidities increase the risk of developing chronic
      conditions such as diabetes mellitus and chronic kidney disease. HIV-associated
      neurologic complications encompass a wide spectrum of pathophysiology and
      symptomatology. Cardiovascular and pulmonary conditions are common among persons 
      with HIV infection. Although some specific antiretroviral medications have been
      linked to disease development, traditional risk factors (e.g., smoking) have
      major roles. Prevention and management of viral hepatitis coinfection are
      important to reduce morbidity and mortality, and new anti-hepatitis C agents
      produce high rates of sustained virologic response. Antiretroviral-associated
      metabolic complications include dyslipidemia, hyperglycemia, and loss of bone
      mineral density. Newer options generally pose less risk of significant systemic
      toxicity and are better tolerated. Family physicians who care for patients with
      HIV infection have a key role in identifying and managing many of these chronic
      complications.
FAU - Chu, Carolyn
AU  - Chu C
AD  - University of California at San Francisco School of Medicine, San Francisco, CA, 
      USA.
FAU - Pollock, Lealah C
AU  - Pollock LC
AD  - University of California at San Francisco School of Medicine, San Francisco, CA, 
      USA.
FAU - Selwyn, Peter A
AU  - Selwyn PA
AD  - Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am Fam Physician
JT  - American family physician
JID - 1272646
EDAT- 2017/08/02 06:00
MHDA- 2017/08/02 06:00
CRDT- 2017/08/02 06:00
AID - d13107 [pii]
PST - ppublish
SO  - Am Fam Physician. 2017 Aug 1;96(3):161-169.