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Establishment and Characterization of an Acute Model of Ocular Hypertension by Laser-Induced Occlusion of Episcleral Veins.

Abstract This study was designed to develop and characterize a laser-induced model of acute intraocular hypertension that permits the study of the anterior segment of the eye.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28763561
OWN - NLM
STAT- MEDLINE
DA  - 20170801
DCOM- 20170803
LR  - 20170803
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Establishment and Characterization of an Acute Model of Ocular Hypertension by
      Laser-Induced Occlusion of Episcleral Veins.
PG  - 3879-3886
LID - 10.1167/iovs.16-20807 [doi]
AB  - Purpose: This study was designed to develop and characterize a laser-induced
      model of acute intraocular hypertension that permits the study of the anterior
      segment of the eye. Methods: CD1 mice aged 5 and 8 weeks were examined for
      elevation of IOP induced by laser photocoagulation. We compared between occlusion
      of episcleral veins alone and when combined with 270 degrees limbal vessel
      occlusion. Anterior chamber angle, corneal thickness, and retinal nerve fiber
      layer (RNFL) thickness were evaluated by anterior- and posterior-segment optical 
      coherence tomography (OCT). Additionally, at day 7 post-procedure, the anterior
      segment was evaluated for inflammatory cellular presentation by histologic
      analysis and OCT, and limbal vessels and whole-mount retina were immunostained
      for CD31 and Brn3a, respectively. Brn3a-positive retinal ganglion cells (RGCs)
      were quantified with ImageJ software. Results: After single or combined laser
      treatment in mice aged 5 or 8 weeks, IOP was significantly elevated for 5 to 6
      days before returning to the baseline by day 7 post-procedure. Anterior segment
      assessment indicated less synechiae in the anterior chamber angle and better
      preserved limbal vessels with single versus combined laser treatment. Corneal
      thickness was significantly increased after single or combined treatment. No
      inflammatory cells were detected in the anterior chamber. The thickness of the
      RNFL and the density of RGCs were both significantly reduced after single or
      combined treatment. Conclusions: Laser photocoagulation of episcleral veins alone
      in CD1 mice aged 5 to 8 weeks may be used to induce ocular hypertension resulting
      in RNFL thinning and ganglion cell loss. This model permits the study of the
      anterior as well as the posterior segment of the eye.
FAU - Zhang, Liwei
AU  - Zhang L
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States 3Department of Ophthalmology, Second Xiangya Hospital, Central
      South University, Changsha, China.
FAU - Li, Guangyu
AU  - Li G
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States.
FAU - Shi, Meng
AU  - Shi M
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States 3Department of Ophthalmology, Second Xiangya Hospital, Central
      South University, Changsha, China.
FAU - Liu, Hsin-Hua
AU  - Liu HH
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States.
FAU - Ge, Shaokui
AU  - Ge S
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States.
FAU - Ou, Yvonne
AU  - Ou Y
AD  - Department of Ophthalmology, University of California, San Francisco, California,
      United States.
FAU - Flanagan, John G
AU  - Flanagan JG
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States.
FAU - Chen, Lu
AU  - Chen L
AD  - Center for Eye Disease and Development, Vision Science Graduate Program,
      University of California, Berkeley, California, United States 2School of
      Optometry and Vision Science, University of California, Berkeley, California,
      United States.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Disease Models, Animal
MH  - Intraocular Pressure/*radiation effects
MH  - Light Coagulation/*adverse effects
MH  - Limbus Corneae/blood supply/pathology
MH  - Ocular Hypertension/*pathology/*physiopathology
MH  - Optic Disk/pathology
MH  - Retina/pathology
MH  - Retinal Ganglion Cells/pathology
MH  - Retinal Vein Occlusion/*pathology
MH  - Sclera/blood supply
MH  - Tomography, Optical Coherence
MH  - Veins
EDAT- 2017/08/02 06:00
MHDA- 2017/08/05 06:00
CRDT- 2017/08/02 06:00
AID - 2646836 [pii]
AID - 10.1167/iovs.16-20807 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3879-3886. doi:
      10.1167/iovs.16-20807.