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The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis.

Abstract Male infertility is a complex disorder caused by genetic, developmental, endocrine, or environmental factors as well as unknown etiology. Polymorphisms in the follicle stimulating hormone beta subunit (FSHB) (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR) (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might disturb normal spermatogenesis and affect male reproductive ability.
PMID
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Authors

Mayor MeshTerms
Keywords

Case-control study

FSHB gene

FSHR gene

Male infertility

Meta-analysis

Polymorphisms

Journal Title bmc medical genetics
Publication Year Start




PMID- 28764642
OWN - NLM
STAT- In-Process
DA  - 20170802
LR  - 20170802
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Aug 01
TI  - The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G
      polymorphisms to men infertility: an association study and meta-analysis.
PG  - 81
LID - 10.1186/s12881-017-0441-4 [doi]
AB  - BACKGROUND: Male infertility is a complex disorder caused by genetic,
      developmental, endocrine, or environmental factors as well as unknown etiology.
      Polymorphisms in the follicle stimulating hormone beta subunit (FSHB)
      (rs10835638, c.-211G > T) and follicle stimulating hormone receptor (FSHR)
      (rs1394205, c.-29G > A; rs6165, c.919A > G; rs6166, c.2039 A > G) genes might
      disturb normal spermatogenesis and affect male reproductive ability. METHODS: To 
      further ascertain the aforementioned effects, we conducted a case-control study
      of 255 infertile men and 340 fertile controls from South China using the Mass
      ARRAY method, which was analyzed by the t-tests and logistic regression analysis 
      using SPSS for Windows 14.0. In addition, a meta-analysis was performed by
      combining our results with previous reports using STATA 12.0. RESULTS: In the
      FSHB or FSHR gene single nucleotide polymorphism (SNP) evaluation, no
      statistically-significant difference was found in the frequency of allelic
      variants or in genotype distribution between cases and controls. However, a
      significant association for the comparison of GAA (P: 0.022, OR: 0.63, 95%CI:
      0.43-0.94) was seen between the oligozoospermia and controls in haplotype
      analysis of rs1394205/rs6165/rs6166. In the meta-analysis, rs6165G allele and
      rs6166 GG genotype were associated with increased risk of the male infertility.
      CONCLUSIONS: This study suggested that FSHR GAA haplotype would exert protective 
      effects against male sterility, which indicated that the combination of three SNP
      genotypes of FSHR was predicted to have a much stronger impact than either one
      alone. Then in the meta-analysis, a significant association was seen between FSHR
      rs6165, rs6166 polymorphisms and male infertility. In terms of male infertility
      with multifactorial etiology, further studies with larger sample sizes and
      different ethnic backgrounds or other risk factors are warranted to clarify the
      potential role of FSHB and FSHR polymorphisms in the pathogenesis of male
      infertility.
FAU - Wu, Qiuyue
AU  - Wu Q
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Zhu, Peiran
AU  - Zhu P
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Jiang, Weijun
AU  - Jiang W
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Liu, Shuaimei
AU  - Liu S
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Ni, Mengxia
AU  - Ni M
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Zhang, Mingchao
AU  - Zhang M
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Li, Weiwei
AU  - Li W
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Zhou, Qing
AU  - Zhou Q
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Cui, Yingxia
AU  - Cui Y
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China.
FAU - Xia, Xinyi
AU  - Xia X
AUID- ORCID: http://orcid.org/0000-0002-7178-0505
AD  - Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, 210002, People's Republic of China. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170801
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
OTO - NOTNLM
OT  - Case-control study
OT  - FSHB gene
OT  - FSHR gene
OT  - Male infertility
OT  - Meta-analysis
OT  - Polymorphisms
EDAT- 2017/08/03 06:00
MHDA- 2017/08/03 06:00
CRDT- 2017/08/03 06:00
PHST- 2016/12/15 [received]
PHST- 2017/07/13 [accepted]
AID - 10.1186/s12881-017-0441-4 [doi]
AID - 10.1186/s12881-017-0441-4 [pii]
PST - epublish
SO  - BMC Med Genet. 2017 Aug 1;18(1):81. doi: 10.1186/s12881-017-0441-4.