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BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate: A meta-analysis.

Abstract Previous studies have investigated the relationship between human bone morphogenetic protein 4 gene (BMP4) rs17563 polymorphism and nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, the results remained inconsistent. Therefore, we conducted a meta-analysis to assess the effect of BMP4 rs17563 polymorphism on NSCL/P.
PMID
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Association between BMP4 rs17563 polymorphism and NSCL/P risk: a meta-analysis.

Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28767592
OWN - NLM
STAT- In-Process
DA  - 20170802
LR  - 20170802
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 31
DP  - 2017 Aug
TI  - BMP4 rs17563 polymorphism and nonsyndromic cleft lip with or without cleft
      palate: A meta-analysis.
PG  - e7676
LID - 10.1097/MD.0000000000007676 [doi]
AB  - BACKGROUND: Previous studies have investigated the relationship between human
      bone morphogenetic protein 4 gene (BMP4) rs17563 polymorphism and nonsyndromic
      cleft lip with or without cleft palate (NSCL/P). However, the results remained
      inconsistent. Therefore, we conducted a meta-analysis to assess the effect of
      BMP4 rs17563 polymorphism on NSCL/P. METHODS: Electronic searches in 5 databases 
      were conducted to select all eligible studies up to March 2017. Odds ratios (ORs)
      with the corresponding 95% confidence intervals (CIs) were calculated to estimate
      the association. Sensitivity analysis was performed to evaluate the results
      stability by excluding each study in turn. Publication bias was assessed by Begg 
      funnel plots and Egger test. RESULTS: A total of 11 case-control studies were
      included in the meta-analysis. The pooled frequency of the minor allele C for
      BMP4 rs17563 was lower in Asians (pooled frequency = 0.33, 95% CI: 0.29-0.37)
      than in Brazilian population (pooled frequency = 0.47, 95% CI: 0.40-0.54). The
      overall results showed no significant association of BMP4 rs17563 polymorphism
      with NSCL/P risk. However, the results turned out to be different when stratified
      by ethnicity. BMP4 rs17563 polymorphism was associated with a higher risk of
      NSCL/P among Asian ethnicity (C vs T: OR = 1.33, 95% CI: 1.02-1.73; CC vs TT: OR 
      = 2.10, 95% CI: 1.28-3.43; CC vs TT + TC: OR = 2.16, 95% CI: 1.34-3.47) and among
      Caucasian population (TC vs TT: OR = 3.36, 95% CI: 2.03-5.54; TC + CC vs TT: OR =
      3.71, 95% CI: 2.43-5.69). Among Brazilian population, BMP4 rs17563 polymorphism
      exerted a significantly protective effect on NSCL/P (C vs T: OR = 0.70, 95% CI:
      0.58-0.84; CC vs TT: OR = 0.54, 95% CI: 0.33-0.88; TC vs TT: OR = 0.55, 95% CI:
      0.44-0.69; TC + CC vs TT: OR = 0.56, 95% CI: 0.45-0.69). CONCLUSION: The results 
      suggest that the C allele of BMP4 rs17563 may be a risk factor for NSCL/P among
      Asians and Caucasians, and may be a protective factor for NSCL/P in Brazilian
      population. Future large-sample studies with appropriate designs among specific
      populations are warranted to evaluate the association.
FAU - Li, Yue-Hua
AU  - Li YH
AD  - aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military 
      Medical University bDepartment of Epidemiology and Health Statistics, School of
      Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi,
      China.
FAU - Yang, Jiaomei
AU  - Yang J
FAU - Zhang, Ju-Lei
AU  - Zhang JL
FAU - Liu, Jia-Qi
AU  - Liu JQ
FAU - Zheng, Zhao
AU  - Zheng Z
FAU - Hu, Da-Hai
AU  - Hu DH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/08/03 06:00
MHDA- 2017/08/03 06:00
CRDT- 2017/08/03 06:00
AID - 10.1097/MD.0000000000007676 [doi]
AID - 00005792-201708040-00028 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Aug;96(31):e7676. doi: 10.1097/MD.0000000000007676.