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Uvemaster: A Mobile App-Based Decision Support System for the Differential Diagnosis of Uveitis.

Abstract To examine the diagnostic accuracy and performance of Uvemaster, a mobile application (app) or diagnostic decision support system (DDSS) for uveitis. The app contains a large database of knowledge including 88 uveitis syndromes each with 76 clinical items, both ocular and systemic (total 6688) and their respective prevalences, and displays a differential diagnoses list (DDL) ordered by sensitivity, specificity, or positive predictive value (PPV).
PMID
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Authors

Mayor MeshTerms

Decision Support Techniques

Mobile Applications

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28772309
OWN - NLM
STAT- MEDLINE
DA  - 20170803
DCOM- 20170811
LR  - 20170811
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Uvemaster: A Mobile App-Based Decision Support System for the Differential
      Diagnosis of Uveitis.
PG  - 3931-3939
LID - 10.1167/iovs.17-21493 [doi]
AB  - Purpose: To examine the diagnostic accuracy and performance of Uvemaster, a
      mobile application (app) or diagnostic decision support system (DDSS) for
      uveitis. The app contains a large database of knowledge including 88 uveitis
      syndromes each with 76 clinical items, both ocular and systemic (total 6688) and 
      their respective prevalences, and displays a differential diagnoses list (DDL)
      ordered by sensitivity, specificity, or positive predictive value (PPV). Methods:
      In this retrospective case-series study, diagnostic accuracy (percentage of cases
      for which a correct diagnosis was obtained) and performance (percentage of cases 
      for which a specific diagnosis was obtained) were determined in reported series
      of patients originally diagnosed by a uveitis specialist with specific uveitis (N
      = 88) and idiopathic uveitis (N = 71), respectively. Results: Diagnostic accuracy
      was 96.6% (95% confidence interval [CI], 93.2-100). By sensitivity, the original 
      diagnosis appeared among the top three in the DDL in 90.9% (95% CI, 84.1-96.6)
      and was the first in 73.9% (95% CI, 63.6-83.0). By PPV, the original diagnosis
      was among the top DDL three in 62.5% (95% CI, 51.1-71.6) and the first in 29.5%
      (95% CI, 20.5-38.6; P < 0.001). In 71 (31.1%) patients originally diagnosed with 
      idiopathic uveitis, 19 new diagnoses were made reducing this series to 52 (22.8%)
      and improving by 8.3% the new rate of diagnosed specific uveitis cases
      (performance = 77.2%; 95% CI, 71.1-82.9). Conclusions: Uvemaster proved accurate 
      and based on the same clinical data was able to detect more cases of specific
      uveitis than the original clinician only-based method.
FAU - Gegundez-Fernandez, Jose A
AU  - Gegundez-Fernandez JA
AD  - Department of Ophthalmology, Ocular Surface and Inflammation Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
FAU - Fernandez-Vigo, Jose I
AU  - Fernandez-Vigo JI
AD  - Department of Ophthalmology, Retina Unit, Hospital Universitario Clinico San
      Carlos, Instituto de Investigacion sanitaria San Carlos (IdISSC), Madrid, Spain.
FAU - Diaz-Valle, David
AU  - Diaz-Valle D
AD  - Department of Ophthalmology, Ocular Surface and Inflammation Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
FAU - Mendez-Fernandez, Rosalia
AU  - Mendez-Fernandez R
AD  - Department of Ophthalmology, Ocular Surface and Inflammation Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
FAU - Cuina-Sardina, Ricardo
AU  - Cuina-Sardina R
AD  - Department of Ophthalmology, Ocular Surface and Inflammation Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
FAU - Santos-Bueso, Enrique
AU  - Santos-Bueso E
AD  - Department of Ophthalmology, Glaucoma and Neuro-Ophthalmology Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
FAU - Benitez-Del-Castillo, Jose M
AU  - Benitez-Del-Castillo JM
AD  - Department of Ophthalmology, Ocular Surface and Inflammation Unit, Hospital
      Universitario Clinico San Carlos, Instituto de Investigacion sanitaria San Carlos
      (IdISSC), Madrid, Spain.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Algorithms
MH  - Child
MH  - Child, Preschool
MH  - Databases, Factual
MH  - *Decision Support Techniques
MH  - Diagnosis, Differential
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mobile Applications
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Uveitis/*diagnosis
EDAT- 2017/08/05 06:00
MHDA- 2017/08/12 06:00
CRDT- 2017/08/04 06:00
AID - 2647588 [pii]
AID - 10.1167/iovs.17-21493 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):3931-3939. doi:
      10.1167/iovs.17-21493.