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A Case of Lung Adenocarcinoma Presenting with Leptomeningeal Carcinomatosis Successfully Treated with Afatinib after Erlotinib-Induced Hepatotoxicity.

Abstract A 65-year-old man was diagnosed with leptomeningeal carcinomatosis based on the findings of cerebrospinal fluid cytology and magnetic resonance imaging(MRI).Treatment with erlotinib and bevacizumab was initiated, and partial improvement in consciousness and MRI findings were obtained.However, it was difficult to continue the treatment because of elevation in levels of liver enzymes and melena.We switched the treatment to afatinib monotherapy, and his consciousness improved immediately.Progression -free survival and overall survival from the initiation of the treatment with afatinib were 7 and 9.4 months, respectively. This clinical course suggests activity of afatinib for central nervous system lesions of EGFRmutated lung cancer.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title gan to kagaku ryoho. cancer & chemotherapy
Publication Year Start




PMID- 28790264
OWN - NLM
STAT- In-Process
DA  - 20170809
LR  - 20170822
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 44
IP  - 7
DP  - 2017 Jul
TI  - [A Case of Lung Adenocarcinoma Presenting with Leptomeningeal Carcinomatosis
      Successfully Treated with Afatinib after Erlotinib-Induced Hepatotoxicity].
PG  - 595-597
AB  - A 65-year-old man was diagnosed with leptomeningeal carcinomatosis based on the
      findings of cerebrospinal fluid cytology and magnetic resonance
      imaging(MRI).Treatment with erlotinib and bevacizumab was initiated, and partial 
      improvement in consciousness and MRI findings were obtained.However, it was
      difficult to continue the treatment because of elevation in levels of liver
      enzymes and melena.We switched the treatment to afatinib monotherapy, and his
      consciousness improved immediately.Progression -free survival and overall
      survival from the initiation of the treatment with afatinib were 7 and 9.4
      months, respectively. This clinical course suggests activity of afatinib for
      central nervous system lesions of EGFRmutated lung cancer.
FAU - Tanaka, Hiroaki
AU  - Tanaka H
AD  - First Dept. of Internal Medicine, Toyama University Hospital.
FAU - Inomata, Minehiko
AU  - Inomata M
FAU - Hayashi, Ryuji
AU  - Hayashi R
FAU - Shimokawa, Kazuki
AU  - Shimokawa K
FAU - Tokui, Kotaro
AU  - Tokui K
FAU - Okazawa, Seisuke
AU  - Okazawa S
FAU - Kambara, Kenta
AU  - Kambara K
FAU - Yamada, Toru
AU  - Yamada T
FAU - Miwa, Toshiro
AU  - Miwa T
FAU - Kashii, Tatsuhiko
AU  - Kashii T
FAU - Konishi, Hirofumi
AU  - Konishi H
FAU - Tobe, Kazuyuki
AU  - Tobe K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
EDAT- 2017/08/10 06:00
MHDA- 2017/08/10 06:00
CRDT- 2017/08/10 06:00
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2017 Jul;44(7):595-597.