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The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation.

Abstract Abstinence from chronic use of addictive drugs triggers an aversive withdrawal syndrome that compels relapse and deters abstinence. Many features of this syndrome are common across multiple drugs, involving both affective and physical symptoms. Some of the network signaling underlying withdrawal symptoms overlaps with activity that is associated with aversive mood states, including anxiety and depression. Given these shared features, it is not surprising that a particular circuit, the dorsal diencephalic conduction system, and the medial habenula (MHb) and interpeduncular nucleus (IPN), in particular, have been identified as critical to the emergence of aversive states that arise both as a result and, independently, of drug addiction. As the features of this circuit continue to be characterized, the MHb-IPN axis is emerging as a viable target for therapeutics to aid in the treatment of addiction to multiple drugs of abuse as well as mood-associated disorders. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
PMID
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Authors

Mayor MeshTerms
Keywords

alcohol

epithalamus

interpeduncular nucleus

mood

stress

withdrawal

Journal Title journal of neurochemistry
Publication Year Start




PMID- 28791703
OWN - NLM
STAT- MEDLINE
DA  - 20170809
DCOM- 20170907
LR  - 20170907
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 142 Suppl 2
DP  - 2017 Aug
TI  - The medial habenula and interpeduncular nucleus circuitry is critical in
      addiction, anxiety, and mood regulation.
PG  - 130-143
LID - 10.1111/jnc.14008 [doi]
AB  - Abstinence from chronic use of addictive drugs triggers an aversive withdrawal
      syndrome that compels relapse and deters abstinence. Many features of this
      syndrome are common across multiple drugs, involving both affective and physical 
      symptoms. Some of the network signaling underlying withdrawal symptoms overlaps
      with activity that is associated with aversive mood states, including anxiety and
      depression. Given these shared features, it is not surprising that a particular
      circuit, the dorsal diencephalic conduction system, and the medial habenula (MHb)
      and interpeduncular nucleus (IPN), in particular, have been identified as
      critical to the emergence of aversive states that arise both as a result and,
      independently, of drug addiction. As the features of this circuit continue to be 
      characterized, the MHb-IPN axis is emerging as a viable target for therapeutics
      to aid in the treatment of addiction to multiple drugs of abuse as well as
      mood-associated disorders. This is an article for the special issue XVth
      International Symposium on Cholinergic Mechanisms.
CI  - (c) 2017 International Society for Neurochemistry.
FAU - McLaughlin, Ian
AU  - McLaughlin I
AD  - Department of Psychiatry, Mahoney Institute for Neurosciences, Perelman School of
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
AD  - Department of Neuroscience Graduate Group, Mahoney Institute for Neurosciences,
      Perelman School of Medicine, University of Pennsylvania, Philadelphia,
      Pennsylvania, USA.
FAU - Dani, John A
AU  - Dani JA
AD  - Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School 
      of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - De Biasi, Mariella
AU  - De Biasi M
AD  - Department of Psychiatry, Mahoney Institute for Neurosciences, Perelman School of
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
AD  - Department of Neuroscience, Mahoney Institute for Neurosciences, Perelman School 
      of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Nicotinic Agonists)
SB  - IM
MH  - Affect/*drug effects/physiology
MH  - Animals
MH  - Anxiety/*drug therapy/physiopathology
MH  - Behavior, Addictive/*drug therapy/physiopathology
MH  - Humans
MH  - Interpeduncular Nucleus/drug effects/*physiopathology
MH  - Nicotinic Agonists/*therapeutic use
MH  - Substance Withdrawal Syndrome/*drug therapy/physiopathology
OTO - NOTNLM
OT  - alcohol
OT  - epithalamus
OT  - interpeduncular nucleus
OT  - mood
OT  - stress
OT  - withdrawal
EDAT- 2017/08/10 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/08/10 06:00
PHST- 2016/12/09 [received]
PHST- 2017/02/09 [revised]
PHST- 2017/02/22 [accepted]
AID - 10.1111/jnc.14008 [doi]
PST - ppublish
SO  - J Neurochem. 2017 Aug;142 Suppl 2:130-143. doi: 10.1111/jnc.14008.