PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.




PMID- 28792880
OWN - NLM
STAT- In-Process
DA  - 20170809
LR  - 20170810
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 377
IP  - 6
DP  - 2017 Aug 10
TI  - Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.
PG  - 513-522
LID - 10.1056/NEJMoa1701717 [doi]
AB  - BACKGROUND: Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for
      nasopharyngeal carcinoma. We conducted a prospective study to investigate whether
      EBV DNA in plasma samples would be useful to screen for early nasopharyngeal
      carcinoma in asymptomatic persons. METHODS: We analyzed EBV DNA in plasma
      specimens to screen participants who did not have symptoms of nasopharyngeal
      carcinoma. Participants with initially positive results were retested
      approximately 4 weeks later, and those with persistently positive EBV DNA in
      plasma underwent nasal endoscopic examination and magnetic resonance imaging
      (MRI). RESULTS: A total of 20,174 participants underwent screening. EBV DNA was
      detectable in plasma samples obtained from 1112 participants (5.5%), and 309
      (1.5% of all participants and 27.8% of those who initially tested positive) had
      persistently positive results on the repeated sample. Among these 309
      participants, 300 underwent endoscopic examination, and 275 underwent both
      endoscopic examination and MRI; of these participants, 34 had nasopharyngeal
      carcinoma. A significantly higher proportion of participants with nasopharyngeal 
      carcinoma that was identified by screening had stage I or II disease than in a
      historical cohort (71% vs. 20%, P<0.001 by the chi-square test) and had superior 
      3-year progression-free survival (97% vs. 70%; hazard ratio, 0.10; 95% confidence
      interval, 0.05 to 0.18). Nine participants declined to undergo further testing,
      and 1 of them presented with advanced nasopharyngeal carcinoma 32 months after
      enrollment. Nasopharyngeal carcinoma developed in only 1 participant with
      negative EBV DNA in plasma samples within 1 year after testing. The sensitivity
      and specificity of EBV DNA in plasma samples in screening for nasopharyngeal
      carcinoma were 97.1% and 98.6%, respectively. CONCLUSIONS: Analysis of EBV DNA in
      plasma samples was useful in screening for early asymptomatic nasopharyngeal
      carcinoma. Nasopharyngeal carcinoma was detected significantly earlier and
      outcomes were better in participants who were identified by screening than in
      those in a historical cohort. (Funded by the Kadoorie Charitable Foundation and
      the Research Grants Council of the Hong Kong government; ClinicalTrials.gov
      number, NCT02063399 .).
FAU - Chan, K C Allen
AU  - Chan KCA
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Woo, John K S
AU  - Woo JKS
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - King, Ann
AU  - King A
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Zee, Benny C Y
AU  - Zee BCY
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Lam, W K Jacky
AU  - Lam WKJ
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Chan, Stephen L
AU  - Chan SL
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Chu, Sam W I
AU  - Chu SWI
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Mak, Constance
AU  - Mak C
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Tse, Irene O L
AU  - Tse IOL
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Leung, Samantha Y M
AU  - Leung SYM
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Chan, Gloria
AU  - Chan G
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Hui, Edwin P
AU  - Hui EP
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Ma, Brigette B Y
AU  - Ma BBY
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Chiu, Rossa W K
AU  - Chiu RWK
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Leung, Sing-Fai
AU  - Leung SF
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - van Hasselt, Andrew C
AU  - van Hasselt AC
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Chan, Anthony T C
AU  - Chan ATC
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
FAU - Lo, Y M Dennis
AU  - Lo YMD
AD  - From the Li Ka Shing Institute of Health Sciences (K.C.A.C., W.K.J.L., S.W.I.C., 
      C.M., I.O.L.T., S.Y.M.L., G.C., R.W.K.C., Y.M.D.L.), the Department of Chemical
      Pathology (K.C.A.C., W.K.J.L., S.W.I.C., C.M., I.O.L.T., S.Y.M.L., G.C.,
      R.W.K.C., Y.M.D.L.), State Key Laboratory of Oncology in South China, Sir Y.K.
      Pao Centre for Cancer (K.C.A.C., W.K.J.L., S.L.C., S.W.I.C., C.M., I.O.L.T.,
      S.Y.M.L., G.C., E.P.H., B.B.Y.M., R.W.K.C., S.-F.L., A.T.C.C., Y.M.D.L.),
      Department of Otorhinolaryngology, Head and Neck Surgery (J.K.S.W., W.K.J.L.,
      A.C.H.), Department of Imaging and Interventional Radiology (A.K.), Jockey Club
      School of Public Health and Primary Care (B.C.Y.Z.), and Department of Clinical
      Oncology (S.L.C., E.P.H., B.B.Y.M., S.-F.L., A.T.C.C.), Chinese University of
      Hong Kong, Prince of Wales Hospital - all in Hong Kong.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
EDAT- 2017/08/10 06:00
MHDA- 2017/08/10 06:00
CRDT- 2017/08/10 06:00
AID - 10.1056/NEJMoa1701717 [doi]
PST - ppublish
SO  - N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717.