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Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China: A STROBE-compliant article.

Abstract Human sex hormone binding globulin (SHBG) level alteration and SHBG gene mutations, especially in rs6259 and rs727428 loci, are associated with male infertility. In this study, the rs6259 and rs727428 loci in SHBG gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to explore the direct relation between these 2 loci and male infertility in Han population of Henan province and to provide information for the pathogenesis, diagnosis, and treatment of male infertility.A total of 366 male Han individuals in Henan province were enrolled in this study. Of the 366 male individuals, 183 infertility patients were served as infertility group and other 183 normal individuals as a control group. SHBG gene rs6259 and rs727428 locus polymorphisms were detected by PCR-RFLP in all patients. Also, genotype frequencies, allele frequency, and haplotype were all analyzed in both groups.There were statistical differences in A allele frequency (P = .017) and GA genotype frequency (P = .016) of SHBG gene rs6259 locus and in CC genotype frequency of SHBG gene rs727428 locus (P = .034) between the 2 groups.Male infertility is associated with GA genotype and A allele of rs6259 locus, as well as CC genotype of rs727428 locus in SHBG gene.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28796064
OWN - NLM
STAT- MEDLINE
DA  - 20170810
DCOM- 20170823
LR  - 20170827
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 32
DP  - 2017 Aug
TI  - Correlation between SHBG gene polymorphism and male infertility in Han population
      of Henan province of China: A STROBE-compliant article.
PG  - e7753
LID - 10.1097/MD.0000000000007753 [doi]
AB  - Human sex hormone binding globulin (SHBG) level alteration and SHBG gene
      mutations, especially in rs6259 and rs727428 loci, are associated with male
      infertility. In this study, the rs6259 and rs727428 loci in SHBG gene were
      detected by polymerase chain reaction-restriction fragment length polymorphism
      (PCR-RFLP) to explore the direct relation between these 2 loci and male
      infertility in Han population of Henan province and to provide information for
      the pathogenesis, diagnosis, and treatment of male infertility.A total of 366
      male Han individuals in Henan province were enrolled in this study. Of the 366
      male individuals, 183 infertility patients were served as infertility group and
      other 183 normal individuals as a control group. SHBG gene rs6259 and rs727428
      locus polymorphisms were detected by PCR-RFLP in all patients. Also, genotype
      frequencies, allele frequency, and haplotype were all analyzed in both
      groups.There were statistical differences in A allele frequency (P = .017) and GA
      genotype frequency (P = .016) of SHBG gene rs6259 locus and in CC genotype
      frequency of SHBG gene rs727428 locus (P = .034) between the 2 groups.Male
      infertility is associated with GA genotype and A allele of rs6259 locus, as well 
      as CC genotype of rs727428 locus in SHBG gene.
FAU - Cui, Yuan-Rong
AU  - Cui YR
AD  - aReproductive Medical Center, the Third Affiliated Hospital of Zhengzhou
      University bDepartment of Medical Genetics and Cell Biology, School of Basic
      Medical Sciences, Zhengzhou University cReproductive Medical Center, the First
      Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
FAU - Guo, Yi-Hong
AU  - Guo YH
FAU - Qiao, Su-Dong
AU  - Qiao SD
FAU - Leng, Li-Fa
AU  - Leng LF
FAU - Xie, Zhen-Hua
AU  - Xie ZH
FAU - Chen, Hui
AU  - Chen H
FAU - Wang, Xing-Ling
AU  - Wang XL
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Sex Hormone-Binding Globulin)
SB  - AIM
SB  - IM
MH  - Adult
MH  - China/epidemiology
MH  - Ethnic Groups
MH  - Gene Frequency
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Infertility, Male/*ethnology/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Sex Hormone-Binding Globulin/*genetics
PMC - PMC5556230
EDAT- 2017/08/11 06:00
MHDA- 2017/08/24 06:00
CRDT- 2017/08/11 06:00
AID - 10.1097/MD.0000000000007753 [doi]
AID - 00005792-201708110-00037 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Aug;96(32):e7753. doi: 10.1097/MD.0000000000007753.