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A new diagnostic marker for differentiating multicentric gliomas from multiple intracranial diffuse large B-cell lymphomas on 18F-FDG PET images.

Abstract Intracranial gliomas and lymphomas may share similar radiological manifestations, while the treatment strategies for them are different. The aim of the study was to investigate the diagnostic value of fluorine-18-fluoro-2-deoxy-D-glucose (F-FDG) positron emission computed tomography (PET) for differentiation of multicentric gliomas and intracranial multiple diffuse large B-cell lymphomas (DLBCLs) as a study of diagnostic accuracy.A total of 32 patients with multiple intracranial tumors visualized on contrast-enhanced magnetic resonance imaging (MRI) were retrospectively evaluated. Histopathological findings confirmed multicentric gliomas and multiple DLBCLs in 17 and 15 patients, respectively. All patients underwent F-FDG PET with or without C-methionine PET. Maximum standardized uptake values (SUVmax) and tumor-to-normal tissue (T/N) ratios were compared between the 2 tumors. The diagnostic value of F-FDG PET for differentiating multicentric gliomas from multiple DLBCLs was evaluated by receiver operating characteristic (ROC) analysis.The SUVmax of multiple DLBCLs was significantly higher than that of multicentric gliomas (P = .009). However, the percentage of maximum difference-value of SUVmax (or T/N ratio) of multiple DLBCLs was significant lower than that of multicentric gliomas (P < .001). The ROC curve demonstrated that the percentage of maximum difference-value of SUVmax (or T/N ratio) on F-FDG PET images could effectively differentiate multicentric gliomas from multiple DLBCLs, with a cut-off value of 44.4%, sensitivity of 64.7%, and specificity of 100% (P < .001).Percentage of maximum difference-value of SUVmax (or T/N ratio) on F-FDG PET images might be a potential indicator for distinguishing multicentric gliomas from intracranial multiple DLBCLs, which might help determine the treatment strategy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title medicine
Publication Year Start




PMID- 28796066
OWN - NLM
STAT- In-Process
DA  - 20170810
LR  - 20170810
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 32
DP  - 2017 Aug
TI  - A new diagnostic marker for differentiating multicentric gliomas from multiple
      intracranial diffuse large B-cell lymphomas on 18F-FDG PET images.
PG  - e7756
LID - 10.1097/MD.0000000000007756 [doi]
AB  - Intracranial gliomas and lymphomas may share similar radiological manifestations,
      while the treatment strategies for them are different. The aim of the study was
      to investigate the diagnostic value of fluorine-18-fluoro-2-deoxy-D-glucose
      (F-FDG) positron emission computed tomography (PET) for differentiation of
      multicentric gliomas and intracranial multiple diffuse large B-cell lymphomas
      (DLBCLs) as a study of diagnostic accuracy.A total of 32 patients with multiple
      intracranial tumors visualized on contrast-enhanced magnetic resonance imaging
      (MRI) were retrospectively evaluated. Histopathological findings confirmed
      multicentric gliomas and multiple DLBCLs in 17 and 15 patients, respectively. All
      patients underwent F-FDG PET with or without C-methionine PET. Maximum
      standardized uptake values (SUVmax) and tumor-to-normal tissue (T/N) ratios were 
      compared between the 2 tumors. The diagnostic value of F-FDG PET for
      differentiating multicentric gliomas from multiple DLBCLs was evaluated by
      receiver operating characteristic (ROC) analysis.The SUVmax of multiple DLBCLs
      was significantly higher than that of multicentric gliomas (P = .009). However,
      the percentage of maximum difference-value of SUVmax (or T/N ratio) of multiple
      DLBCLs was significant lower than that of multicentric gliomas (P &lt; .001). The
      ROC curve demonstrated that the percentage of maximum difference-value of SUVmax 
      (or T/N ratio) on F-FDG PET images could effectively differentiate multicentric
      gliomas from multiple DLBCLs, with a cut-off value of 44.4%, sensitivity of
      64.7%, and specificity of 100% (P &lt; .001).Percentage of maximum difference-value 
      of SUVmax (or T/N ratio) on F-FDG PET images might be a potential indicator for
      distinguishing multicentric gliomas from intracranial multiple DLBCLs, which
      might help determine the treatment strategy.
FAU - Wang, Kai
AU  - Wang K
AD  - aDepartment of Nuclear Medicine bDepartment of Neurosurgery, Beijing Tiantan
      Hospital, Capital Medical University cChina National Clinical Research Center for
      Neurological Diseases dBeijing Institute for Brain Disorders and Beijing Key
      Laboratory of Brain Tumor eBeijing Neurosurgical Institute fDepartment of
      Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
FAU - Zhao, Xiaobin
AU  - Zhao X
FAU - Chen, Qian
AU  - Chen Q
FAU - Fan, Di
AU  - Fan D
FAU - Qiao, Zhen
AU  - Qiao Z
FAU - Lin, Song
AU  - Lin S
FAU - Jiang, Tao
AU  - Jiang T
FAU - Dai, Jianping
AU  - Dai J
FAU - Ai, Lin
AU  - Ai L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
EDAT- 2017/08/11 06:00
MHDA- 2017/08/11 06:00
CRDT- 2017/08/11 06:00
AID - 10.1097/MD.0000000000007756 [doi]
AID - 00005792-201708110-00039 [pii]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Aug;96(32):e7756. doi: 10.1097/MD.0000000000007756.