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Evaluation of the possible protective role of naringenin on gentamicin-induced ototoxicity: A preliminary study.

Abstract The purpose of this study is to evaluate the possible protective role of naringenin in gentamicin-induced ototoxicity through an audiological, biochemical and histopathological evaluation.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-oxidative status

Auditory brainstem responses

Gentamicin

Naringenin

Otoacoustic emission

Ototoxicity

Oxidative status

TUNEL

Journal Title international journal of pediatric otorhinolaryngology
Publication Year Start




PMID- 28802382
OWN - NLM
STAT- MEDLINE
DA  - 20170813
DCOM- 20170907
LR  - 20170907
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 100
DP  - 2017 Sep
TI  - Evaluation of the possible protective role of naringenin on gentamicin-induced
      ototoxicity: A preliminary study.
PG  - 247-253
LID - S0165-5876(17)30321-X [pii]
LID - 10.1016/j.ijporl.2017.07.008 [doi]
AB  - OBJECTIVES: The purpose of this study is to evaluate the possible protective role
      of naringenin in gentamicin-induced ototoxicity through an audiological,
      biochemical and histopathological evaluation. METHODS: This study was conducted
      on 32 adult male rats that were randomized into 4 groups(control, gentamicin,
      naringenin + gentamicin, and naringenin). Naringenin was given to the rats via
      oral gavage in a dose of 50 mg/kg/day during the 14 day study period. Gentamicin 
      was given by the intraperitoneal route in a dose of 120 mg/kg/day. Audiological
      assessment was performed by the distortion product otoacoustic emission (DPOAE)
      and auditory brainstem response (ABR) measurements, applied to all rats at the
      beginning of the study, and also on day 14. Biochemical parameters were
      calculated on day 14 to evaluate the oxidative and antioxidative status. Their
      cochleae were removed and examined histopathologically, also on day 14. The
      cochlea of animals were evaluated with the terminal deoxynucleotidyl
      transferase-mediated dUTPbiotin nick end labeling (TUNEL) method for apoptosis.
      RESULTS: On days 14, DPOAE values and ABR thresholds were preserved in group
      3(naringenin + gentamicin) when compared with group 2(gentamicin)(p < 0.008). The
      total oxidant status values and oxidative stress index values were significantly 
      higher in group 2(gentamicin) than in other groups (p < 0.008). The total
      antioxidant status value was significantly higher in group 3(naringenin +
      gentamicin) and group 4(naringenin) than in group 2(gentamicin)(p < 0.008). The
      number of TUNEL positive cells in both the organ of Corti and the stria
      vascularis were found to be statistically lower in group 3(naringenin +
      gentamicin) than in group 2(gentamicin)(p < 0.05). CONCLUSION: Our study has
      demonstrated that the ototoxic effect generated by gentamicin could be
      ameliorated with the concurrent use of naringenin.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Kocak, I
AU  - Kocak I
AD  - Department of Otolaringology, Koc University Hospital, Istanbul, Turkey.
      Electronic address: [email protected]
FAU - Sarac, S
AU  - Sarac S
AD  - Department of Otolaringology, Koc University Hospital, Istanbul, Turkey.
FAU - Aydogan, E
AU  - Aydogan E
AD  - Department of Otolaringology, Koc University Hospital, Istanbul, Turkey.
FAU - Senturk, E
AU  - Senturk E
AD  - Department of Otolaringology, Alaca State Hospital, Corum, Turkey.
FAU - Akakin, D
AU  - Akakin D
AD  - Department of Histology and Embryology, Marmara University School of Medicine,
      Istanbul, Turkey.
FAU - Koroglu, K
AU  - Koroglu K
AD  - Department of Histology and Embryology, Marmara University School of Medicine,
      Istanbul, Turkey.
FAU - Ozer, O F
AU  - Ozer OF
AD  - Department of Biochemistry, Bezmialem Vakif University, Medical Faculty,
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170709
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Flavanones)
RN  - 0 (Gentamicins)
RN  - HN5425SBF2 (naringenin)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*adverse effects
MH  - Antioxidants/pharmacology
MH  - Apoptosis/drug effects
MH  - Cochlea/drug effects
MH  - Ear Diseases/*chemically induced
MH  - Ear, Inner/drug effects
MH  - Evoked Potentials, Auditory, Brain Stem/*drug effects
MH  - Flavanones/*pharmacology
MH  - Gentamicins/*adverse effects
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Otoacoustic Emissions, Spontaneous/*drug effects
MH  - Rats
OTO - NOTNLM
OT  - Anti-oxidative status
OT  - Auditory brainstem responses
OT  - Gentamicin
OT  - Naringenin
OT  - Otoacoustic emission
OT  - Ototoxicity
OT  - Oxidative status
OT  - TUNEL
EDAT- 2017/08/15 06:00
MHDA- 2017/09/08 06:00
CRDT- 2017/08/14 06:00
PHST- 2017/02/27 [received]
PHST- 2017/06/16 [revised]
PHST- 2017/07/07 [accepted]
AID - S0165-5876(17)30321-X [pii]
AID - 10.1016/j.ijporl.2017.07.008 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2017 Sep;100:247-253. doi:
      10.1016/j.ijporl.2017.07.008. Epub 2017 Jul 9.