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Viral Retinopathy in Experimental Models of Zika Infection.

Abstract Emerging evidence has shown that both congenital and adult Zika virus (ZIKV) infection can cause eye diseases. The goals of the current study were to explore mechanisms and pathophysiology of ZIKV-induced eye defects.
PMID
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Authors

Mayor MeshTerms

Disease Models, Animal

Keywords
Journal Title investigative ophthalmology & visual science
Publication Year Start




PMID- 28810265
OWN - NLM
STAT- MEDLINE
DA  - 20170815
DCOM- 20170825
LR  - 20170825
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 10
DP  - 2017 Aug 01
TI  - Viral Retinopathy in Experimental Models of Zika Infection.
PG  - 4075-4085
LID - 10.1167/iovs.17-22016 [doi]
AB  - Purpose: Emerging evidence has shown that both congenital and adult Zika virus
      (ZIKV) infection can cause eye diseases. The goals of the current study were to
      explore mechanisms and pathophysiology of ZIKV-induced eye defects. Methods:
      Wild-type or A129 interferon type I receptor-deficient mice were infected by
      either FSS13025 or Mex1-7 strain of ZIKV. Retinal histopathology was measured at 
      different time points after infection. The presence of viral RNA and protein in
      the retina was determined by in situ hybridization and immunofluorescence
      staining, respectively. Growth curves of ZIKV in permissive retinal cells were
      assessed in cultured retinal pigment epithelial (RPE) and Muller glial cells.
      Results: ZIKV-infected mice developed a spectrum of ocular pathologies that
      affected multiple layers of the retina. A primary target of ZIKV in the eye was
      Muller glial cells, which displayed decreased neurotrophic function and increased
      expression of proinflammatory cytokines after infection. ZIKV also infected RPE; 
      and both the RPE and Muller cells expressed viral entry receptors TYRO3 and AXL. 
      Retinitis, focal retinal degeneration, and ganglion cell loss were observed after
      the clearance of viral particles. Conclusions: Our data suggest that ZIKV can
      infect infant eyes with immature blood-retinal barrier and cause structural
      damages to the retina. The ocular findings in microcephalic infants may not be
      solely caused by ZIKV-induced impairment of neurodevelopment.
FAU - Zhao, Zhenyang
AU  - Zhao Z
AD  - Department of Ophthalmology & Visual Sciences, University of Texas Medical
      Branch, Galveston, Texas, United States.
FAU - Yang, Matthew
AU  - Yang M
AD  - Department of Ophthalmology & Visual Sciences, University of Texas Medical
      Branch, Galveston, Texas, United States.
FAU - Azar, Sasha R
AU  - Azar SR
AD  - Institute for Translational Sciences, University of Texas Medical Branch,
      Galveston, Texas, United States.
FAU - Soong, Lynn
AU  - Soong L
AD  - Department of Microbiology & Immunology, University of Texas Medical Branch,
      Galveston, Texas, United States.
FAU - Weaver, Scott C
AU  - Weaver SC
AD  - Department of Microbiology & Immunology, University of Texas Medical Branch,
      Galveston, Texas, United States.
AD  - Department of Pathology, University of Texas Medical Branch, Galveston, Texas,
      United States.
AD  - Institute for Human Infections and Immunity, University of Texas Medical Branch, 
      Galveston, Texas, United States.
FAU - Sun, Jiaren
AU  - Sun J
AD  - Department of Microbiology & Immunology, University of Texas Medical Branch,
      Galveston, Texas, United States.
FAU - Chen, Yan
AU  - Chen Y
AD  - Department of Ophthalmology & Visual Sciences, University of Texas Medical
      Branch, Galveston, Texas, United States.
FAU - Rossi, Shannan L
AU  - Rossi SL
AD  - Department of Microbiology & Immunology, University of Texas Medical Branch,
      Galveston, Texas, United States.
AD  - Department of Pathology, University of Texas Medical Branch, Galveston, Texas,
      United States.
AD  - Institute for Human Infections and Immunity, University of Texas Medical Branch, 
      Galveston, Texas, United States.
FAU - Cai, Jiyang
AU  - Cai J
AD  - Department of Ophthalmology & Visual Sciences, University of Texas Medical
      Branch, Galveston, Texas, United States.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (NS1 protein, zika virus)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Nonstructural Proteins)
SB  - IM
MH  - Animals
MH  - Blood-Retinal Barrier
MH  - Cells, Cultured
MH  - *Disease Models, Animal
MH  - Ependymoglial Cells/pathology/*virology
MH  - Eye Infections, Viral/pathology/*virology
MH  - Flow Cytometry
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - RNA, Viral/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Retinal Diseases/pathology/*virology
MH  - Retinal Pigment Epithelium/pathology/*virology
MH  - Uveitis, Posterior/pathology/virology
MH  - Viral Nonstructural Proteins/metabolism
MH  - Virus Replication/physiology
MH  - Zika Virus/physiology
MH  - Zika Virus Infection/pathology/*virology
PMC - PMC5558627
EDAT- 2017/08/16 06:00
MHDA- 2017/08/26 06:00
CRDT- 2017/08/16 06:00
AID - 2649079 [pii]
AID - 10.1167/iovs.17-22016 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4075-4085. doi:
      10.1167/iovs.17-22016.