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Clinical Practice Guideline: Safe Medication Use in the ICU.

Abstract To provide ICU clinicians with evidence-based guidance on safe medication use practices for the critically ill.
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Journal Title critical care medicine
Publication Year Start




PMID- 28816851
OWN - NLM
STAT- In-Process
DA  - 20170817
LR  - 20170817
IS  - 1530-0293 (Electronic)
IS  - 0090-3493 (Linking)
VI  - 45
IP  - 9
DP  - 2017 Sep
TI  - Clinical Practice Guideline: Safe Medication Use in the ICU.
PG  - e877-e915
LID - 10.1097/CCM.0000000000002533 [doi]
AB  - OBJECTIVE: To provide ICU clinicians with evidence-based guidance on safe
      medication use practices for the critically ill. DATA SOURCES: PubMed, Cochrane
      Database of Systematic Reviews, Cochrane Central Register of Controlled Trials,
      CINAHL, Scopus, and ISI Web of Science for relevant material to December 2015.
      STUDY SELECTION: Based on three key components: 1) environment and patients, 2)
      the medication use process, and 3) the patient safety surveillance system. The
      committee collectively developed Population, Intervention, Comparator, Outcome
      questions and quality of evidence statements pertaining to medication errors and 
      adverse drug events addressing the key components. A total of 34 Population,
      Intervention, Comparator, Outcome questions, five quality of evidence statements,
      and one commentary on disclosure was developed. DATA EXTRACTION: Subcommittee
      members were assigned selected Population, Intervention, Comparator, Outcome
      questions or quality of evidence statements. Subcommittee members completed their
      Grading of Recommendations Assessment, Development, and Evaluation of the
      question with his/her quality of evidence assessment and proposed strength of
      recommendation, then the draft was reviewed by the relevant subcommittee. The
      subcommittee collectively reviewed the evidence profiles for each question they
      developed. After the draft was discussed and approved by the entire committee,
      then the document was circulated among all members for voting on the quality of
      evidence and strength of recommendation. DATA SYNTHESIS: The committee followed
      the principles of the Grading of Recommendations Assessment, Development, and
      Evaluation system to determine quality of evidence and strength of
      recommendations. CONCLUSIONS: This guideline evaluates the ICU environment as a
      risk for medication-related events and the environmental changes that are
      possible to improve safe medication use. Prevention strategies for
      medication-related events are reviewed by medication use process node
      (prescribing, distribution, administration, monitoring). Detailed considerations 
      to an active surveillance system that includes reporting, identification, and
      evaluation are discussed. Also, highlighted is the need for future research for
      safe medication practices that is specific to critically ill patients.
FAU - Kane-Gill, Sandra L
AU  - Kane-Gill SL
AD  - 1Department of Pharmacy and Therapeutics, Critical Care Medicine, Biomedical
      Informatics and Clinical Translational Science Institute, University of
      Pittsburgh, Pittsburgh, PA. 2Department of Pharmacy, UPMC, Pittsburgh, PA.
      3Department of Pharmacy Practice and Science, The Ohio State University, College 
      of Pharmacy, Columbus, OH. 4Department of Pharmacy, Banner University Medical
      Center Phoenix, Phoenix, AZ. 5Department of Pharmacy Practice and Science,
      University of Maryland School of Pharmacy, Baltimore, MD. 6Department of
      Pharmacy, Yale-New Haven Hospital, New Haven, CT. 7Department of Pharmacy
      Services, Touro College of Pharmacy, New York, NY. 8Kingsbrook Jewish Medical
      Center, Brooklyn, NY. 9UPMC-Presbyterian, Pittsburgh, PA. 10Department of
      Medicine, University of Chicago, Chicago, IL. 11Pediatric Critical Care,
      Department of Pediatrics, Inova Children's Hospital, Falls Church, VA. 12College 
      of Nursing, University of Massachusetts Amherst, Amherst, MA. 13Inova Fairfax
      Hospital, Falls Church, VA. 14Departments of Anesthesia/CCM and Surgery, and
      Health Policy & Management, Johns Hopkins Schools of Medicine and Bloomberg
      School of Public Health, Baltimore, MD. 15Department of Pharmacy, Seton Medical
      Center Williamson, Round Rock, TX. 16Department of Pediatrics and Critical Care
      Medicine, Medical College of Wisconsin, Milwaukee, WI. 17Children's Hospital of
      Wisconsin, Milwaukee, WI. 18Department of Pharmacy, UMass Memorial Medical
      Center, Worcester, MA.
FAU - Dasta, Joseph F
AU  - Dasta JF
FAU - Buckley, Mitchell S
AU  - Buckley MS
FAU - Devabhakthuni, Sandeep
AU  - Devabhakthuni S
FAU - Liu, Michael
AU  - Liu M
FAU - Cohen, Henry
AU  - Cohen H
FAU - George, Elisabeth L
AU  - George EL
FAU - Pohlman, Anne S
AU  - Pohlman AS
FAU - Agarwal, Swati
AU  - Agarwal S
FAU - Henneman, Elizabeth A
AU  - Henneman EA
FAU - Bejian, Sharon M
AU  - Bejian SM
FAU - Berenholtz, Sean M
AU  - Berenholtz SM
FAU - Pepin, Jodie L
AU  - Pepin JL
FAU - Scanlon, Mathew C
AU  - Scanlon MC
FAU - Smith, Brian S
AU  - Smith BS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
EDAT- 2017/08/18 06:00
MHDA- 2017/08/18 06:00
CRDT- 2017/08/18 06:00
AID - 10.1097/CCM.0000000000002533 [doi]
AID - 00003246-201709000-00032 [pii]
PST - ppublish
SO  - Crit Care Med. 2017 Sep;45(9):e877-e915. doi: 10.1097/CCM.0000000000002533.