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Caprine brucellosis: A historically neglected disease with significant impact on public health.

Abstract Caprine brucellosis is a chronic infectious disease caused by the gram-negative cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths, and the delivery of weak offspring are the characteristic clinical signs of the disease that is associated with an extensive negative impact in a flock's productivity. B. melitensis is also the most virulent Brucella species for humans, responsible for a severely debilitating and disabling illness that results in high morbidity with intermittent fever, chills, sweats, weakness, myalgia, abortion, osteoarticular complications, endocarditis, depression, anorexia, and low mortality. Historical observations indicate that goats have been the hosts of B. melitensis for centuries; but around 1905, the Greek physician Themistokles Zammit was able to build the epidemiological link between "Malta fever" and the consumption of goat milk. While the disease has been successfully managed in most industrialized countries, it remains a significant burden on goat and human health in the Mediterranean region, the Middle East, Central and Southeast Asia (including India and China), sub-Saharan Africa, and certain areas in Latin America, where approximately 3.5 billion people live at risk. In this review, we describe a historical evolution of the disease, highlight the current worldwide distribution, and estimate (by simple formula) the approximate costs of brucellosis outbreaks to meat- and milk-producing farms and the economic losses associated with the disease in humans. Successful control leading to eradication of caprine brucellosis in the developing world will require a coordinated Global One Health approach involving active involvement of human and animal health efforts to enhance public health and improve livestock productivity.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos neglected tropical diseases
Publication Year Start




PMID- 28817647
OWN - NLM
STAT- In-Process
DA  - 20170817
LR  - 20170817
IS  - 1935-2735 (Electronic)
IS  - 1935-2727 (Linking)
VI  - 11
IP  - 8
DP  - 2017 Aug
TI  - Caprine brucellosis: A historically neglected disease with significant impact on 
      public health.
PG  - e0005692
LID - 10.1371/journal.pntd.0005692 [doi]
AB  - Caprine brucellosis is a chronic infectious disease caused by the gram-negative
      cocci-bacillus Brucella melitensis. Middle- to late-term abortion, stillbirths,
      and the delivery of weak offspring are the characteristic clinical signs of the
      disease that is associated with an extensive negative impact in a flock's
      productivity. B. melitensis is also the most virulent Brucella species for
      humans, responsible for a severely debilitating and disabling illness that
      results in high morbidity with intermittent fever, chills, sweats, weakness,
      myalgia, abortion, osteoarticular complications, endocarditis, depression,
      anorexia, and low mortality. Historical observations indicate that goats have
      been the hosts of B. melitensis for centuries; but around 1905, the Greek
      physician Themistokles Zammit was able to build the epidemiological link between 
      "Malta fever" and the consumption of goat milk. While the disease has been
      successfully managed in most industrialized countries, it remains a significant
      burden on goat and human health in the Mediterranean region, the Middle East,
      Central and Southeast Asia (including India and China), sub-Saharan Africa, and
      certain areas in Latin America, where approximately 3.5 billion people live at
      risk. In this review, we describe a historical evolution of the disease,
      highlight the current worldwide distribution, and estimate (by simple formula)
      the approximate costs of brucellosis outbreaks to meat- and milk-producing farms 
      and the economic losses associated with the disease in humans. Successful control
      leading to eradication of caprine brucellosis in the developing world will
      require a coordinated Global One Health approach involving active involvement of 
      human and animal health efforts to enhance public health and improve livestock
      productivity.
FAU - Rossetti, Carlos A
AU  - Rossetti CA
AUID- ORCID: http://orcid.org/0000-0002-6932-2521
AD  - Instituto de Patobiologia, CICVyA-CNIA, INTA. Nicolas Repetto y de Los Reseros
      s/n, Hurlingham, Buenos Aires, Argentina.
FAU - Arenas-Gamboa, Angela M
AU  - Arenas-Gamboa AM
AD  - Department of Veterinary Pathobiology, College of Veterinary Medicine &
      Biomedical Sciences, Texas A&M University, College Station, Texas, United States 
      of America.
FAU - Maurizio, Estefania
AU  - Maurizio E
AD  - Instituto de Patobiologia, CICVyA-CNIA, INTA. Nicolas Repetto y de Los Reseros
      s/n, Hurlingham, Buenos Aires, Argentina.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170817
PL  - United States
TA  - PLoS Negl Trop Dis
JT  - PLoS neglected tropical diseases
JID - 101291488
EDAT- 2017/08/18 06:00
MHDA- 2017/08/18 06:00
CRDT- 2017/08/18 06:00
AID - 10.1371/journal.pntd.0005692 [doi]
AID - PNTD-D-17-00722 [pii]
PST - epublish
SO  - PLoS Negl Trop Dis. 2017 Aug 17;11(8):e0005692. doi:
      10.1371/journal.pntd.0005692. eCollection 2017 Aug.