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Hepatoprotective and antioxidant effects of single clove garlic against CCl4-induced hepatic damage in rabbits.

Abstract The increase in demand and consumption of single clove garlic or 'Solo garlic' (Allium sativum) has resulted in an increase in research on its therapeutic properties. The present study aims to evaluate the antioxidant activities, oxidant-scavenging efficiency and preventive effects of SCG (single clove garlic) and MCG (multi clove garlic) on CCl4-induced acute hepatotoxicity in male rabbits.
PMID
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Authors

Mayor MeshTerms

Phytotherapy

Keywords

Allium sativum

Antioxidant

Biochemical parameters

Carbon tetrachloride

Hepatotoxicity

Oxidative toxicity

Single clove garlic

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28818066
OWN - NLM
STAT- MEDLINE
DA  - 20170818
DCOM- 20170901
LR  - 20170901
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 17
TI  - Hepatoprotective and antioxidant effects of single clove garlic against
      CCl4-induced hepatic damage in rabbits.
PG  - 411
LID - 10.1186/s12906-017-1916-8 [doi]
AB  - BACKGROUND: The increase in demand and consumption of single clove garlic or
      'Solo garlic' (Allium sativum) has resulted in an increase in research on its
      therapeutic properties. The present study aims to evaluate the antioxidant
      activities, oxidant-scavenging efficiency and preventive effects of SCG (single
      clove garlic) and MCG (multi clove garlic) on CCl4-induced acute hepatotoxicity
      in male rabbits. METHODS: For this purpose, rabbits were orally administered with
      3 ml of CCl4 /kg of body weight, followed by 0.8 g of MCG or SCG/kg twice a week 
      for three successive weeks. Oxidative hepatotoxicity was then assessed. RESULTS: 
      SCG extracts exhibited higher antioxidant capacity than the MCG extract.
      Scavenging ability of SCG showed significant (p < 0.05) elevation against
      2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide radicals in comparison to
      MCG. In addition, total phenolic content of SCG was significantly elevated (p <
      0.001), thereby suggesting that the composition of garlic storage constituents
      varies with the number of cloves present. CCl4-induced hepatotoxicity
      demonstrated histological changes including severe damage in the structure of
      liver tissues which correlated well to oxidative stress levels. Simultaneously,
      administration of SCG resulted in a significant reduction of serum alkaline
      phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase
      (ALT), and total bilirubin (TB) levels in addition to improvement in some
      histological parameters. Low levels of lipid peroxidation (malondialdehyde, MDA) 
      (p < 0.001), along with a huge reduction in peroxidase (POx) (p < 0.001) revealed
      protection against oxidative toxicity in the liver homogenate. Higher levels of
      catalase (CAT) (p < 0.001) and superoxide dismutase (SOD) (p < 0.05) when
      compared to the MCG test (TM) group indicates that removal of H2O2 is based on
      CAT activity in SCG test (TS) group rather than the POx activity demonstrated in 
      the former group. CONCLUSION: The present study indicates that SCG possesses more
      protective ability than MCG against CCl4-induced liver injury and might be an
      effective alternative medicine against acute oxidative liver toxicity.
FAU - Naji, Khalid Mohammed
AU  - Naji KM
AD  - Biochemistry section, Department of Chemistry, Faculty of science, Sana'a
      University, P.O. Box 13499, Sana'a, Yemen. [email protected]
FAU - Al-Shaibani, Elham Shukri
AU  - Al-Shaibani ES
AD  - Zoology section, Department of Biology, Faculty of Science, Sana'a University,
      Sana'a, Yemen.
FAU - Alhadi, Fatima A
AU  - Alhadi FA
AD  - Botany section, Department of Biology, Faculty of Science, Sana'a University,
      Sana'a, Yemen.
FAU - Al-Soudi, Safa'a Abdulrzaq
AU  - Al-Soudi SA
AD  - Zoology section, Department of Biology, Faculty of Science, Sana'a University,
      Sana'a, Yemen.
FAU - D'souza, Myrene R
AU  - D'souza MR
AD  - Department of Biochemistry, Mount Carmel College, No.58, Palace Road, Vasanth
      Nagar, Bengaluru, Karnataka, 560052, India.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Antioxidants)
RN  - 0 (Phenols)
RN  - 0 (Plant Extracts)
RN  - 11062-77-4 (Superoxides)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Alanine Transaminase/blood
MH  - Animals
MH  - Antioxidants/metabolism/pharmacology/*therapeutic use
MH  - Aspartate Aminotransferases/blood
MH  - Bilirubin/blood
MH  - Carbon Tetrachloride
MH  - Catalase/metabolism
MH  - Chemical and Drug Induced Liver Injury/*drug therapy
MH  - Garlic/*chemistry
MH  - Lipid Peroxidation/drug effects
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Peroxidase/metabolism
MH  - Phenols/analysis/pharmacology/therapeutic use
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Rabbits
MH  - Superoxide Dismutase/metabolism
MH  - Superoxides/metabolism
PMC - PMC5561638
OTO - NOTNLM
OT  - Allium sativum
OT  - Antioxidant
OT  - Biochemical parameters
OT  - Carbon tetrachloride
OT  - Hepatotoxicity
OT  - Oxidative toxicity
OT  - Single clove garlic
EDAT- 2017/08/19 06:00
MHDA- 2017/09/02 06:00
CRDT- 2017/08/19 06:00
PHST- 2017/03/21 [received]
PHST- 2017/08/08 [accepted]
AID - 10.1186/s12906-017-1916-8 [doi]
AID - 10.1186/s12906-017-1916-8 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Aug 17;17(1):411. doi: 10.1186/s12906-017-1916-8.