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Clinical features and antinuclear antibodies profile among adults with systemic lupus erythematosus and lupus nephritis: a cross-sectional study.

Abstract Limited data is available regarding the clinical manifestations and pattern of Systemic Lupus Erythematosus (SLE) in Sudan. This study aimed to determine the clinical manifestations and Antinuclear Antibodies (ANA) profile among Sudanese adults with SLE and lupus nephritis (LN).
PMID
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Authors

Mayor MeshTerms
Keywords

ANA profile

SLE

Sudan

lupus nephritis

Journal Title the pan african medical journal
Publication Year Start




PMID- 28819535
OWN - NLM
STAT- MEDLINE
DA  - 20170818
DCOM- 20170904
LR  - 20170904
IS  - 1937-8688 (Electronic)
VI  - 27
DP  - 2017
TI  - Clinical features and antinuclear antibodies profile among adults with systemic
      lupus erythematosus and lupus nephritis: a cross-sectional study.
PG  - 114
LID - 10.11604/pamj.2017.27.114.5981 [doi]
AB  - INTRODUCTION: Limited data is available regarding the clinical manifestations and
      pattern of Systemic Lupus Erythematosus (SLE) in Sudan. This study aimed to
      determine the clinical manifestations and Antinuclear Antibodies (ANA) profile
      among Sudanese adults with SLE and lupus nephritis (LN). METHODS: A descriptive
      study was conducted in Omdurman Military Hospital, Sudan. It included all adults 
      with SLE and on regular follow-up during the study period (December 2012 to May
      2013). These were investigated regarding their demographic details, clinical
      features, and immunological profile (ANA, anti-double stranded DNA, and ANA
      profile 3 levels). Patients with LN had their pattern of renal involvement
      described; furthermore, associations between the various SLE reactive antibodies 
      and the histological diagnosis of lupus were studied. RESULTS: Sixty-two Sudanese
      adults with SLE were included, their mean age was 31 +/- 10.9 year. Females made 
      93.5% of patients. A clear predominance of those of Arab ancestry was seen, with 
      most patients being from the Ja'alin and Shaigiya ethnic groups accounting for
      29% and 12.9%, respectively. Arthritis was the dominant clinical manifestation
      seen in 85.5%, whereas renal involvement was seen in 66.1% of patients. Lupus
      nephritis class III was the dominant histological lesion, seen in 39% of
      patients. On correlating the ANA profile to the histopathological diagnosis of
      LN, anti-Nucleosomes and anti-AMA-M2 autoantibodies were found to be
      significantly associated with LN class IV and class VI, respectively (P values < 
      0.05). CONCLUSION: Further epidemiological studies regarding SLE and its ANA
      profile remain essential as they might help predicting the clinical patterns of
      the disease and its prognosis.
FAU - Ahmed, Nashwa
AU  - Ahmed N
AD  - Sudan Medical Specialization Board, Ministry of Health, Khartoum, Sudan.
FAU - Shigidi, Mazin
AU  - Shigidi M
AD  - Salma Centre for Kidney Diseases, Faculty of Medicine, University of Khartoum,
      Sudan.
FAU - Al Agib, Al Nour
AU  - Al Agib AN
AD  - Faculty of Medicine, Karrai University, Sudan.
FAU - Abdelrahman, Hassan
AU  - Abdelrahman H
AD  - Faculty of Medicine, University of Medical Sciences and Technology, Sudan.
FAU - Taha, Elshafie
AU  - Taha E
AD  - Cardiology Department, Al Ain Hospital, United Arab Emirates.
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Antinuclear/*immunology
MH  - Arthritis/*epidemiology/etiology
MH  - Autoantibodies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Hospitals, Military
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*epidemiology/immunology/physiopathology
MH  - Lupus Nephritis/*epidemiology/immunology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Sudan/epidemiology
MH  - Young Adult
PMC - PMC5554640
OTO - NOTNLM
OT  - ANA profile
OT  - SLE
OT  - Sudan
OT  - lupus nephritis
EDAT- 2017/08/19 06:00
MHDA- 2017/09/05 06:00
CRDT- 2017/08/19 06:00
PHST- 2014/12/20 [received]
PHST- 2017/06/07 [accepted]
AID - 10.11604/pamj.2017.27.114.5981 [doi]
AID - PAMJ-27-114 [pii]
PST - epublish
SO  - Pan Afr Med J. 2017 Jun 14;27:114. doi: 10.11604/pamj.2017.27.114.5981.
      eCollection 2017.