PubTransformer

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PMID- 28821195
OWN - NLM
STAT- MEDLINE
DA  - 20170819
DCOM- 20170906
LR  - 20170906
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 148
IP  - 3
DP  - 2017 Sep 01
TI  - Atypical IgG4+ Plasmacytic Proliferations and Lymphomas: Characterization of 11
      Cases.
PG  - 215-235
LID - 10.1093/AJCP/AQX067 [doi]
AB  - Objectives: To report the clinicopathologic features of monotypic immunoglobulin 
      G4+ (IgG4+) lymphoid and plasmacytic proliferations. Methods: Cases were
      identified from the pathology files. Pathology and clinical materials were
      reviewed. Results: Eleven cases of monotypic IgG4+ proliferations were identified
      at nodal, orbital, or salivary sites. Six cases (three men, three women; age,
      57-94 years) met criteria for lymphoma or plasma cell neoplasia. Most contained
      frequent Mott cells. Five cases (three men, two women; age, 40-80 years) had
      restricted proliferations of atypical/monotypic IgG4+ plasma cells in a
      background of reactive lymphoid hyperplasia or inflammation. Conclusions:
      Monotypic IgG4+ proliferations include lymphomas, plasmacytic neoplasms, and a
      previously uncharacterized group of proliferations not meeting criteria for
      conventional hematolymphoid neoplasia. Distinct features included prominent Mott 
      cells and/or monotypic plasma cells within follicles. The proliferations were
      infrequently associated with IgG4-related disease (IgG4-RD). Our findings raise
      questions regarding the relationship between clonal IgG4+ proliferations,
      reactive/inflammatory processes, and IgG4-RD.
FAU - Bledsoe, Jacob R
AU  - Bledsoe JR
AD  - Department of Pathology, UMass Memorial Medical Center,Worcester, MA.
FAU - Wallace, Zachary S
AU  - Wallace ZS
AD  - Division of Rheumatology, Allergy, and Immunology.
FAU - Deshpande, Vikram
AU  - Deshpande V
AD  - The James Homer Wright Pathology Laboratories, Massachusetts General Hospital,
      Boston.
FAU - Richter, Joshua R
AU  - Richter JR
AD  - The John Theurer Cancer Center, Hackensack University Medical Center, Hackensack,
      NJ.
FAU - Klapman, Jason
AU  - Klapman J
AD  - Gastrointestinal Tumor Program, Moffitt Cancer Center, Tampa, FL.
FAU - Cowan, Andrew
AU  - Cowan A
AD  - Division of Medical Oncology, University of Washington, Seattle.
FAU - Stone, John H
AU  - Stone JH
AD  - Division of Rheumatology, Allergy, and Immunology.
FAU - Ferry, Judith A
AU  - Ferry JA
AD  - The James Homer Wright Pathology Laboratories, Massachusetts General Hospital,
      Boston.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Immunoglobulin G)
SB  - AIM
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - *Immunoglobulin G
MH  - Lymphoma/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Plasma Cell/immunology/*pathology
MH  - Plasma Cells/immunology/*pathology
OTO - NOTNLM
OT  - IgG4
OT  - IgG4-related disease
OT  - Lymphoma
EDAT- 2017/08/20 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/08/20 06:00
AID - 4061004 [pii]
AID - 10.1093/AJCP/AQX067 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2017 Sep 1;148(3):215-235. doi: 10.1093/AJCP/AQX067.