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Evidence based anti-osteoporosis effects of Periplaneta americana L on osteoblasts, osteoclasts, vascular endothelial cells and bone marrow derived mesenchymal stem cells.

Abstract Kangfuxin (KFX) is the ethanol extract of Periplaneta americana L, which has been widely used in the Traditional Chinese Medicine for the repair and regeneration of injured organ and tissues with long history. This study is to investigate the influence of KFX in the various cellular activities and evaluate the anti-osteoporosis potential of KFX.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-osteoporosis

BMSCs

HUVECs

Osteoblasts

Osteoclasts

Periplaneta americana L

Journal Title bmc complementary and alternative medicine
Publication Year Start




PMID- 28821253
OWN - NLM
STAT- In-Process
DA  - 20170819
LR  - 20170822
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 17
IP  - 1
DP  - 2017 Aug 18
TI  - Evidence based anti-osteoporosis effects of Periplaneta americana L on
      osteoblasts, osteoclasts, vascular endothelial cells and bone marrow derived
      mesenchymal stem cells.
PG  - 413
LID - 10.1186/s12906-017-1917-7 [doi]
AB  - BACKGROUND: Kangfuxin (KFX) is the ethanol extract of Periplaneta americana L,
      which has been widely used in the Traditional Chinese Medicine for the repair and
      regeneration of injured organ and tissues with long history. This study is to
      investigate the influence of KFX in the various cellular activities and evaluate 
      the anti-osteoporosis potential of KFX. METHODS: The influence of the KFX in the 
      cellular activities, including: 1) migration, osteocalcin secretion of
      osteoblasts; 2) apoptosis of osteoclasts; 3) migration and tube formation of
      human umbilical vein endothelial cell (HUVEC); and 4) proliferation, cell cycle
      regulation and migration of bone marrow mesenchymal stem cells (BMSCs), were
      investigated systematically. RESULTS: KFX was shown to significantly 1) Promote
      of the migration of osteoblasts, HUVEC, and BMSCs; 2) Increase the secretion of
      osteocalcin and mineralization of osteoblasts; 3) Accelerate the apoptosis of
      osteoclasts; 4) Stimulate the proliferation and regulate the cell cycle of BMSCs.
      CONCLUSION: Taken together, these results provide the evidence for the
      osteogenesis, anti-osteoporosis and angiogenesis effects of KFX, with the
      mechanism of activating the bone formation through stimulating the osteoblasts
      and HUVECs, as well as inhibiting the bone absorption by inhibiting the
      osteoclasts activities. The KFX was definitely shown a promising bone turnover
      agent with great potential for anti-osteoporosis treatment.
FAU - Huang, Yan-Fen
AU  - Huang YF
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China.
FAU - Li, Long-Jian
AU  - Li LJ
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China.
AD  - Zhejiang Provincial Corps Hospital of Chinese People's Armed Police Forces,
      Jiaxing, Zhejiang, People's Republic of China.
FAU - Gao, Si-Qian
AU  - Gao SQ
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China.
FAU - Chu, Yang
AU  - Chu Y
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China.
FAU - Niu, Jie
AU  - Niu J
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China.
FAU - Geng, Fu-Neng
AU  - Geng FN
AD  - Sichuan Engineering Research Center for Medicinal Animals, Yingmenkou Road 88#,
      Chengdu City, Sicuan Province, People's Republic of China.
AD  - GOODDOCTOR Pharmaceutical Company, Yingmenkou Road 88#, Chengdu City, Sicuan
      Province, People's Republic of China.
FAU - Shen, Yong-Mei
AU  - Shen YM
AD  - GOODDOCTOR Pharmaceutical Company, Yingmenkou Road 88#, Chengdu City, Sicuan
      Province, People's Republic of China.
FAU - Peng, Li-Hua
AU  - Peng LH
AD  - Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang
      University, 866# Yuhangtang Road, Hangzhou City, 310058, People's Republic of
      China. [email protected]
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Macau University of
      Science and Technology, Macau, People's Republic of China. [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170818
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
PMC - PMC5563055
OTO - NOTNLM
OT  - Anti-osteoporosis
OT  - BMSCs
OT  - HUVECs
OT  - Osteoblasts
OT  - Osteoclasts
OT  - Periplaneta americana L
EDAT- 2017/08/20 06:00
MHDA- 2017/08/20 06:00
CRDT- 2017/08/20 06:00
PHST- 2017/04/25 [received]
PHST- 2017/08/09 [accepted]
AID - 10.1186/s12906-017-1917-7 [doi]
AID - 10.1186/s12906-017-1917-7 [pii]
PST - epublish
SO  - BMC Complement Altern Med. 2017 Aug 18;17(1):413. doi: 10.1186/s12906-017-1917-7.