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Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.

Abstract Up to now, numerous case-control studies have reported the associations between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent result. Hence we performed current systematic review and meta-analysis to clarify the controversial results.
PMID
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Authors

Mayor MeshTerms
Keywords

FTO

Meta-analysis

Polycystic ovary syndrome

Polymorphism

Journal Title bmc medical genetics
Publication Year Start




PMID- 28826396
OWN - NLM
STAT- MEDLINE
DA  - 20170822
DCOM- 20170905
LR  - 20170906
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 18
IP  - 1
DP  - 2017 Aug 21
TI  - Association between fat mass and obesity associated (FTO) gene rs9939609 A/T
      polymorphism and polycystic ovary syndrome: a systematic review and
      meta-analysis.
PG  - 89
LID - 10.1186/s12881-017-0452-1 [doi]
AB  - BACKGROUND: Up to now, numerous case-control studies have reported the
      associations between fat mass and obesity associated (FTO) gene rs9939609 A/T
      polymorphism and polycystic ovary syndrome (PCOS), however, without a consistent 
      result. Hence we performed current systematic review and meta-analysis to clarify
      the controversial results. METHODS: Case-control studies reporting the
      relationship of rs9939609 A/T polymorphism and PCOS published before April 2015
      were searched in Pubmed database without language restriction. Data was analyzed 
      by Review Manager 5.2. RESULTS: A total of five studies involving 5010 PCOS
      patients and 5300 controls were included for further meta-analysis. The results
      of meta-analysis showed that the FTO gene rs9939609 A/T polymorphism was
      significantly different between PCOS group and control group in different gene
      models (For AA + AT vs. TT: OR = 1.41, 95% CI = 1.28-1.55, P < 0.00001. For AA
      vs. AT + TT: OR = 1.54, 95% CI = 1.25-1.89, P < 0.0001. For AA vs. TT: OR = 1.74,
      95% CI = 1.38-2.18, P < 0.00001. For A vs. T: OR = 1.36, 95% CI = 1.25-1.47, P < 
      0.00001, respectively) suggesting that A allele was a risk factor for PCOS
      susceptibility. Furthermore, subgroup analysis in Asian and Caucasian ethnicities
      also found significant association between rs9939609 A/T polymorphism and PCOS
      (In Asian subgroup: OR = 1.43, 95% CI = 1.29-1.59, P < 0.0001. In Caucasian
      subgroup: OR = 1.33, 95% CI = 1.08-1.64, P = 0.008) CONCLUSION: This
      meta-analysis suggests that rs9939609 A/T polymorphism of FTO gene is associated 
      with PCOS risk, and that A allele is a risk factor for PCOS susceptibility
      simultaneously.
FAU - Liu, Ai Ling
AU  - Liu AL
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
AD  - Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,
      Hengyang, 421001, China.
AD  - The Key Laboratory of Biological Toxicology and Ecological Restoration of
      Hengyang City, Hengyang, Hunan Province, 421001, China.
FAU - Xie, Hui Jun
AU  - Xie HJ
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
FAU - Xie, Hong Yan
AU  - Xie HY
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
FAU - Liu, Jun
AU  - Liu J
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
FAU - Yin, Jie
AU  - Yin J
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
FAU - Hu, Jin Song
AU  - Hu JS
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
FAU - Peng, Cui Ying
AU  - Peng CY
AUID- ORCID: http://orcid.org/0000-0002-8689-1873
AD  - Institute of Biological Science, School of Pharmaceutical and Biological Science,
      University of South China, Hengyang, Hunan Province, 421001, China.
      [email protected]
AD  - Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,
      Hengyang, 421001, China. [email protected]
AD  - The Key Laboratory of Biological Toxicology and Ecological Restoration of
      Hengyang City, Hengyang, Hunan Province, 421001, China. [email protected]
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170821
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
SB  - IM
MH  - Adiposity/*genetics
MH  - Alleles
MH  - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics
MH  - Asian Continental Ancestry Group/genetics
MH  - Body Mass Index
MH  - Databases, Factual
MH  - European Continental Ancestry Group/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Obesity/complications/*genetics
MH  - Polycystic Ovary Syndrome/complications/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Sensitivity and Specificity
PMC - PMC5563909
OTO - NOTNLM
OT  - FTO
OT  - Meta-analysis
OT  - Polycystic ovary syndrome
OT  - Polymorphism
EDAT- 2017/08/23 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/08/23 06:00
PHST- 2016/10/28 [received]
PHST- 2017/08/14 [accepted]
AID - 10.1186/s12881-017-0452-1 [doi]
AID - 10.1186/s12881-017-0452-1 [pii]
PST - epublish
SO  - BMC Med Genet. 2017 Aug 21;18(1):89. doi: 10.1186/s12881-017-0452-1.